{"id":"https://openalex.org/W2300548165","doi":"https://doi.org/10.1042/bss0610033","title":"Nitric oxide and reactive oxygen species in vascular injury","display_name":"Nitric oxide and reactive oxygen species in vascular injury","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2300548165","doi":"https://doi.org/10.1042/bss0610033","mag":"2300548165","pmid":"https://pubmed.ncbi.nlm.nih.gov/8660401"},"language":"en","primary_location":{"id":"doi:10.1042/bss0610033","doi":"https://doi.org/10.1042/bss0610033","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bss0610033","pdf_url":null,"source":{"id":"https://openalex.org/S194663005","display_name":"Biochemical Society Symposia","issn_l":"0067-8694","issn":["0067-8694","1744-1439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Symposia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032637422","display_name":"Homero Rubbo","orcid":"https://orcid.org/0000-0002-7897-6551","observed_orcids":["https://orcid.org/0000-0002-7897-6551"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Homero Rubbo","raw_affiliation_strings":["Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049556891","display_name":"Margaret M. Tarpey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Tarpey","raw_affiliation_strings":["Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013958345","display_name":"Bruce \u0391. Freeman","orcid":"https://orcid.org/0000-0002-2028-8369","observed_orcids":["https://orcid.org/0000-0002-2028-8369"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce A. Freeman","raw_affiliation_strings":["Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":0.2209,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.59504257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"61","issue":null,"first_page":"33","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lipoprotein-oxidation","display_name":"lipoprotein oxidation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6340000033378601},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.5830000042915344},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tissue-protection","display_name":"tissue protection","score":0.5870000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.46700000762939453},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.7879999876022339},{"id":"https://openalex.org/keywords/thiols","display_name":"thiols","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7852424383163452},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6364632248878479},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5932404398918152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5560431480407715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5396419167518616},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.5180400013923645},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49169737100601196},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4885178804397583},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4839373230934143},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46552297472953796},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.4559387266635895},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.4496946930885315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44666534662246704},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.415966272354126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4032554030418396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.308849036693573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30183273553848267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22793442010879517},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16620951890945435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16587156057357788},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1042/bss0610033","doi":"https://doi.org/10.1042/bss0610033","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bss0610033","pdf_url":null,"source":{"id":"https://openalex.org/S194663005","display_name":"Biochemical Society Symposia","issn_l":"0067-8694","issn":["0067-8694","1744-1439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Symposia","raw_type":"journal-article"},{"id":"pmid:8660401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8660401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society symposium","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","score":0.5400000214576721,"display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2041394247","https://openalex.org/W2109893157"],"related_works":["https://openalex.org/W2037894687","https://openalex.org/W1538751795","https://openalex.org/W1983886923","https://openalex.org/W2127710249","https://openalex.org/W2403621848","https://openalex.org/W96093571","https://openalex.org/W2093847882","https://openalex.org/W2131017492","https://openalex.org/W2122386753","https://openalex.org/W2079513720"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1],"(.NO),":[2],"a":[3,14,73,122,171,217,225],"free":[4,88,233],"radical":[5,66,89],"species":[6,203],"produced":[7],"by":[8,174],"several":[9,193],"mammalian":[10],"cell":[11],"types,":[12],"plays":[13],"role":[15,28,75,173],"in":[16,31,76],"regulation":[17],"of":[18,29,41,46,48,50,115,159,166,176,183,188,200,228],"vascular,":[19,78],"neurological":[20],"and":[21,25,43,57,63,80,90,110,127,129,137,148,151,197,204,214,231],"immunological":[22],"signal":[23],"transduction":[24],"function.":[26],"The":[27,38,180,208],".NO":[30,70,103,117,161,189,222],"cytotoxic":[32],"events":[33],"is":[34],"acquiring":[35],"increased":[36],"significance.":[37],"high":[39],"rate":[40],"production":[42,49,162],"broad":[44],"distribution":[45],"sites":[47,196],".NO,":[51],"combined":[52],"with":[53,60,216],"its":[54,113],"facile":[55],"direct":[56],"indirect":[58],"reactions":[59,187,230],"metalloproteins,":[61],"thiols":[62],"various":[64],"oxygen":[65],"species,":[67],"assures":[68],"that":[69,157],"will":[71,190],"play":[72],"central":[74,226],"regulating":[77],"physiological":[79],"cellular":[81],"homoeostasis,":[82],"as":[83,85,100,121,142,144,219,224],"well":[84,143],"critical":[86],"intravascular":[87],"oxidant":[91,229],"reactions.":[92],"At":[93],"the":[94],"same":[95],"time,":[96],"there":[97],"are":[98],"contradictions":[99],"to":[101,220],"whether":[102],"mediates":[104],"or":[105,163],"limits":[106],"free-radical-mediated":[107],"tissue":[108,131],"injury,":[109],"uncertainty":[111],"regarding":[112],"mechanisms":[114],"action.":[116],"has":[118],"been":[119],"portrayed":[120],"pathogenic":[123],"mediator":[124],"during":[125],"ischaemia-reperfusion,":[126],"inflammatory":[128,150],"septic":[130],"injury.":[132],"In":[133],"contrast,":[134],"cell-,":[135],"metal-":[136],"oxidant-induced":[138],"lipoprotein":[139],"oxidation":[140],"events,":[141],"hepatic,":[145],"cerebrovascular,":[146],"pulmonary":[147],"myocardial":[149],"ischaemia-reperfusion":[152],"injury":[153],"studies,":[154],"show":[155],"convincingly":[156],"stimulation":[158],"endogenous":[160],"exogenous":[164],"administration":[165],".NO-donating":[167],"molecules":[168],"can":[169],"serve":[170],"protective":[172],"inhibition":[175],"often":[177],"oxidant-related":[178],"mechanisms.":[179],"final":[181],"outcome":[182],"toxic":[184],"versus":[185],"tissue-protective":[186],"depend":[191],"on":[192],"factors,":[194],"including":[195],"relative":[198],"concentrations":[199],"individual":[201],"reactive":[202],"their":[205],"diffusion":[206],"distances.":[207],"following":[209],"sections":[210],"address":[211],"these":[212],"issues":[213],"conclude":[215],"proposal":[218],"how":[221],"serves":[223],"regulator":[227],"diverse":[232],"radical-related":[234],"disease":[235],"processes.":[236]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
