{"id":"https://openalex.org/W2300531124","doi":"https://doi.org/10.4049/jimmunol.184.supp.96.7","title":"OR3: an anti-TCR autoantibody and immunomodulation (96.7)","display_name":"OR3: an anti-TCR autoantibody and immunomodulation (96.7)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2300531124","doi":"https://doi.org/10.4049/jimmunol.184.supp.96.7","mag":"2300531124"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.96.7","doi":"https://doi.org/10.4049/jimmunol.184.supp.96.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.96.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072361065","display_name":"Parvathi Ranganathan","orcid":"https://orcid.org/0000-0003-4963-3629","observed_orcids":["https://orcid.org/0000-0003-4963-3629"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvathi Ranganathan","raw_affiliation_strings":["Immunobiology, University of Arizona , Tucson, AZ","1Immunobiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology, University of Arizona , Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"1Immunobiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112056782","display_name":"Samuel F. Schluter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Schluter","raw_affiliation_strings":["Immunobiology, University of Arizona , Tucson, AZ","1Immunobiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology, University of Arizona , Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"1Immunobiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"96.7","last_page":"96.7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cd4-t-cell-activation","display_name":"CD4+ T cell activation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cytokine-inhibition","display_name":"cytokine inhibition","score":0.722000002861023},{"id":"https://openalex.org/keywords/t-cell-proliferation-inhibition","display_name":"T cell proliferation inhibition","score":0.6010000109672546},{"id":"https://openalex.org/keywords/peptide-mhc-binding","display_name":"peptide-MHC binding","score":0.609000027179718},{"id":"https://openalex.org/keywords/autoantibody-therapy","display_name":"autoantibody therapy","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7376366853713989},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6806269884109497},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6323947906494141},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5470238327980042},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5116612911224365},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4776022136211395},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4685569405555725},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4459831118583679},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.41236791014671326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3377329707145691},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.334745317697525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32485759258270264},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30442604422569275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10206401348114014},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06514528393745422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.96.7","doi":"https://doi.org/10.4049/jimmunol.184.supp.96.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.96.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W168317131","https://openalex.org/W2064263020","https://openalex.org/W818168287","https://openalex.org/W2462177712","https://openalex.org/W21358243","https://openalex.org/W20444393","https://openalex.org/W13373609","https://openalex.org/W140107794","https://openalex.org/W1549018058","https://openalex.org/W2080984357"],"abstract_inverted_index":{"Abstract":[0],"The":[1,168],"presence":[2],"of":[3,6,15,28,39,46,83,99,107,134,159,182,188,196,206,217],"low":[4,37],"levels":[5,38],"circulating":[7],"self-reactive":[8],"autoantibodies":[9,24],"(AAbs)":[10],"is":[11,25,175],"a":[12,16,72,84,176,193,207,215],"normal":[13],"feature":[14],"healthy":[17],"immune":[18,31,185,198],"system.":[19],"One":[20],"suggested":[21],"function":[22],"for":[23,91,203,231],"the":[26,47,100,171,180,183,197,204],"control":[27],"autoreactivity":[29],"and":[30,119,139,143,173,220,224],"homeostasis.":[32],"Healthy":[33],"humans":[34],"spontaneously":[35],"express":[36],"serum":[40],"AAbs":[41],"directed":[42],"against":[43],"defined":[44],"epitopes":[45],"T":[48,114,125,137,151,161,218],"Cell":[49],"Receptor":[50],"(TCR)":[51],"V\u03b2":[52],"chains":[53],"that":[54,211,227],"can":[55,190,228],"be":[56,229],"markedly":[57],"elevated":[58],"in":[59,179],"individuals":[60],"with":[61,86],"autoimmune":[62],"diseases":[63],"such":[64],"as":[65],"Rheumatoid":[66],"Arthritis":[67],"(RA).":[68],"Here,":[69],"we":[70],"describe":[71],"monoclonal":[73],"IgM":[74],"AAb,":[75],"OR3,":[76],"derived":[77],"from":[78],"peripheral":[79],"blood":[80],"B":[81],"cells":[82,115,138,219],"patient":[85],"RA.":[87],"OR3":[88,127,153],"was":[89],"selected":[90],"its":[92],"ability":[93],"to":[94,96,112,120,192,213],"bind":[95],"residues":[97],"23-38":[98],"complementarity":[101],"determining":[102],"region":[103],"1":[104],"(CDR1)":[105],"segment":[106],"human":[108,117],"V\u03b28.1.":[109],"It":[110],"binds":[111,212],"Jurkat":[113],"expressing":[116],"V\u03b28.1":[118],"ovalbumin-specific":[121],"transgenic":[122],"murine":[123],"DO11.10":[124,135,150,160],"cells.":[126,152],"significantly":[128],"reduces":[129],"ova":[130],"peptide":[131],"stimulated":[132],"activation":[133,181],"CD4+":[136],"inhibits":[140],"IFN-\u03b3,":[141],"IL-2":[142],"IL-10":[144],"cytokine":[145],"secretion":[146],"by":[147],"antigen":[148,156],"specific":[149],"also":[154],"blocks":[155],"induced":[157],"proliferation":[158],"cells,":[162],"but":[163],"does":[164],"not":[165],"initiate":[166],"apoptosis.":[167],"interaction":[169],"between":[170],"TCR":[172],"MHC:peptide":[174],"critical":[177],"point":[178],"adaptive":[184],"response,":[186],"disruption":[187],"which,":[189],"lead":[191],"global":[194],"dampening":[195],"response.":[199],"We":[200],"show":[201],"evidence":[202],"development":[205],"unique":[208],"anti-TCR":[209],"autoantibody":[210],"only":[214],"subset":[216],"possesses":[221],"potent":[222],"blocking":[223],"anti-inflammatory":[225],"properties":[226],"harnessed":[230],"therapeutic":[232],"use.":[233]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}