{"id":"https://openalex.org/W2300415809","doi":null,"title":"Enzyme-based nitric oxide releasing thin films and scaffolds","display_name":"Enzyme-based nitric oxide releasing thin films and scaffolds","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2300415809","mag":"2300415809"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:csu1407870702","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043860341","display_name":"Bhagya Gunasekera","orcid":"https://orcid.org/0000-0002-1901-7676","observed_orcids":["https://orcid.org/0000-0002-1901-7676"]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bhagya Gunasekera","raw_affiliation_strings":["Cleveland State University"],"raw_orcid":"https://orcid.org/0000-0002-1901-7676","affiliations":[{"raw_affiliation_string":"Cleveland State University","institution_ids":["https://openalex.org/I102607778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043860341"],"corresponding_institution_ids":["https://openalex.org/I102607778"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.7929999828338623},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.7680000066757202},{"id":"https://openalex.org/keywords/thin-films","display_name":"thin films","score":0.7160000205039978},{"id":"https://openalex.org/keywords/electrospun-scaffolds","display_name":"electrospun scaffolds","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antithrombogenic-coatings","display_name":"antithrombogenic coatings","score":0.7900000214576721},{"id":"https://openalex.org/keywords/biomedical-implants","display_name":"biomedical implants","score":0.8920000195503235},{"id":"https://openalex.org/keywords/layer-by-layer-assembly","display_name":"layer-by-layer assembly","score":0.7429999709129333},{"id":"https://openalex.org/keywords/michaelis-menten-kinetics","display_name":"Michaelis-Menten kinetics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.5049999952316284},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.6430000066757202},{"id":"https://openalex.org/keywords/polyelectrolyte-films","display_name":"polyelectrolyte films","score":0.6010000109672546},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7431798577308655},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5646628141403198},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.5342872142791748},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5155946612358093},{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.4877949059009552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48119479417800903},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4738759696483612},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.4489075243473053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44044387340545654},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.38101083040237427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12727683782577515},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:csu1407870702","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","raw_type":"text"},{"id":"pmh:oai:engagedscholarship.csuohio.edu:etdarchive-1113","doi":null,"is_oa":false,"landing_page_url":"https://engagedscholarship.csuohio.edu/etdarchive/114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400889","display_name":"EngagedScholarship @ Cleveland State University (Cleveland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102607778","host_organization_name":"Cleveland State University","host_organization_lineage":["https://openalex.org/I102607778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Archive","raw_type":"text"},{"id":"mag:2300415809","doi":null,"is_oa":false,"landing_page_url":"https://engagedscholarship.csuohio.edu/cgi/viewcontent.cgi?article=1113&context=etdarchive","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:csu1407870702","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1407870702","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332624","display_name":"College of Science and Health","ror":"https://ror.org/04xtx5t16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2300415809.pdf","grobid_xml":"https://content.openalex.org/works/W2300415809.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W114586137","https://openalex.org/W207951093","https://openalex.org/W1484925335","https://openalex.org/W1541963905","https://openalex.org/W1543242698","https://openalex.org/W1549240509","https://openalex.org/W1605080122","https://openalex.org/W1634736267","https://openalex.org/W1827044363","https://openalex.org/W1868411085","https://openalex.org/W1873359408","https://openalex.org/W1920761902","https://openalex.org/W1934853983","https://openalex.org/W1964200863","https://openalex.org/W1964336590","https://openalex.org/W1965617063","https://openalex.org/W1971968732","https://openalex.org/W1973211198","https://openalex.org/W1973215203","https://openalex.org/W1974529031","https://openalex.org/W1979363917","https://openalex.org/W1979460082","https://openalex.org/W1979848820","https://openalex.org/W1981598340","https://openalex.org/W1987013989","https://openalex.org/W1991262180","https://openalex.org/W1997022840","https://openalex.org/W1997369874","https://openalex.org/W1998869888","https://openalex.org/W2002036385","https://openalex.org/W2004659139","https://openalex.org/W2005469488","https://openalex.org/W2007137945","https://openalex.org/W2008743229","https://openalex.org/W2008894535","https://openalex.org/W2009013636","https://openalex.org/W2009974465","https://openalex.org/W2013796894","https://openalex.org/W2017703675","https://openalex.org/W2018860941","https://openalex.org/W2018950346","https://openalex.org/W2021334430","https://openalex.org/W2022416833","https://openalex.org/W2023995606","https://openalex.org/W2025565664","https://openalex.org/W2025739322","https://openalex.org/W2026260546","https://openalex.org/W2027909722","https://openalex.org/W2028133927","https://openalex.org/W2029259783","https://openalex.org/W2032990895","https://openalex.org/W2036886263","https://openalex.org/W2041498558","https://openalex.org/W2044921286","https://openalex.org/W2045591496","https://openalex.org/W2048635427","https://openalex.org/W2050696166","https://openalex.org/W2055592745","https://openalex.org/W2057151607","https://openalex.org/W2058175127","https://openalex.org/W2058867517","https://openalex.org/W2060034829","https://openalex.org/W2064100055","https://openalex.org/W2065625962","https://openalex.org/W2067057392","https://openalex.org/W2072204309","https://openalex.org/W2075242633","https://openalex.org/W2077287304","https://openalex.org/W2077420888","https://openalex.org/W2083203405","https://openalex.org/W2083733554","https://openalex.org/W2084236029","https://openalex.org/W2086037463","https://openalex.org/W2086158492","https://openalex.org/W2089065337","https://openalex.org/W2092140089","https://openalex.org/W2092281736","https://openalex.org/W2093115787","https://openalex.org/W2109117281","https://openalex.org/W2119347133","https://openalex.org/W2119585663","https://openalex.org/W2124288159","https://openalex.org/W2128545518","https://openalex.org/W2132591359","https://openalex.org/W2132774797","https://openalex.org/W2135505698","https://openalex.org/W2139036153","https://openalex.org/W2140991303","https://openalex.org/W2144257419","https://openalex.org/W2146837799","https://openalex.org/W2147956574","https://openalex.org/W2158616001","https://openalex.org/W2160975112","https://openalex.org/W2161986813","https://openalex.org/W2166040862","https://openalex.org/W2168409167","https://openalex.org/W2223998566","https://openalex.org/W2322678149","https://openalex.org/W2394792209","https://openalex.org/W2409273576","https://openalex.org/W2726062218"],"related_works":["https://openalex.org/W2330145894","https://openalex.org/W2276352349","https://openalex.org/W3114827750","https://openalex.org/W3024633857","https://openalex.org/W2793204753","https://openalex.org/W2898612839","https://openalex.org/W7011838921","https://openalex.org/W606731129","https://openalex.org/W2790827215","https://openalex.org/W2515827168"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1,38,123,141,215,300,323],"synthase":[2,124],"enzyme":[3,154,235,260,276,290],"(NOS)":[4],"embedded":[5,71],"in":[6,98,132,155,237,262,326],"thin":[7,134,157,172,189,204,220,263],"films":[8,135,221,308],"and":[9,25,49,70,110,136,185,207,222,233,302],"scaffolds,":[10],"when":[11,324],"exposed":[12],"to":[13,45,76,166,176,212,230,266,289],"a":[14,20,42,128,255,270,327],"solution":[15],"of":[16,22,29,36,59,80,88,105,153,170,187,192,199,202,249,254,286,332],"its":[17],"substrate":[18,287],"arginine,":[19],"source":[21],"reducing":[23],"equivalents,":[24],"other":[26],"required":[27],"ingredients":[28,331],"the":[30,53,57,74,78,103,151,178,197,218,240,252,275,297,303,330],"NOS":[31,333],"reaction,":[32],"can":[33,51],"release":[34,142,216],"fluxes":[35],"nitric":[37,122,140,214,299,322],"(NO).The":[39],"latter":[40],"is":[41,125],"molecule":[43],"known":[44],"counteract":[46],"platelet":[47],"aggregation,":[48],"thus":[50],"prevent":[52],"thrombosis":[54],"cascade":[55],"on":[56,182],"surfaces":[58,184],"implantable":[60,81],"medical":[61],"devices.Therefore":[62],"NO":[63],"antithrombogenic":[64],"regimens":[65],"such":[66],"as":[67,116,127],"active":[68,133,179],"coatings":[69,109],"scaffolds":[72,112,138,320],"have":[73,113],"potential":[75,114],"increase":[77],"lifespan":[79],"biomaterials.Layer-by-layer":[82],"electrostatic":[83],"adsorption":[84],"allows":[85,282],"for":[86,139,217,227,307],"assembly":[87],"multi-component":[89],"protein/polyelectrolytes":[90],"nanostructured":[91],"films.Electrospun":[92],"fiber":[93,319],"matrices":[94],"may":[95],"embed":[96,231],"proteins":[97],"aqueous":[99],"pockets":[100],"that":[101],"allow":[102],"formation":[104],"functional":[106,108,129],"scaffolds.Such":[107],"polymer":[111,273,317],"applications":[115],"antithrombotic":[117],"surfaces.In":[118],"this":[119],"project,":[120],"inducible":[121],"proposed":[126],"v":[130],"component":[131],"electrospun":[137,238],"under":[143],"physiologic":[144],"conditions.Atomic":[145],"force":[146],"microscopic":[147],"(AFM)":[148],"imaging":[149],"confirms":[150],"presence":[152],"adsorbed":[156,183,278,314],"films.Fourier":[158],"transform":[159],"infrared":[160],"(FTIR)":[161],"spectroscopic":[162],"analysis":[163,191],"was":[164,174],"used":[165,175,211],"characterize":[167,177],"structure-function":[168],"relationships":[169],"NOS-containing":[171,188,203],"films.Voltammetry":[173],"catalyst":[180],"concentration":[181],"activity":[186,236],"films.Further,":[190],"cyclic":[193],"voltammetric":[194],"data":[195],"enabled":[196],"study":[198],"Michaelis-Menten":[200],"kinetics":[201],"films.Other":[205],"spectrophotometric":[206],"spectrofluorometric":[208],"assays":[209],"were":[210,225,305],"monitor":[213],"NOS-based":[219],"scaffolds.Three":[223],"polymers":[224],"characterized":[226],"their":[228],"ability":[229],"iNOSoxy":[232],"show":[234],"scaffolds.For":[239],"LbL":[241],"method,":[242],"during":[243],"protein":[244],"adsorption,":[245],"an":[246],"adjusted":[247],"pH":[248,267,280,293,311],"8.6":[250,294,312],"or":[251,269,313],"use":[253],"branched":[256,316],"matrix":[257],"immobilizes":[258],"more":[259],"units":[261],"layers":[264],"compared":[265,288],"7.0":[268,281],"linearly":[271],"structured":[272],"matrix.However,":[274],"structure":[277,291],"at":[279,310],"faster":[283],"catalytic":[284],"turnover":[285],"from":[292],"immobilization.Overall,":[295],"both":[296],"cumulative":[298],"output":[301],"flux":[304],"higher":[306],"immobilized":[309],"onto":[315],"matrices.Electrospun":[318],"produce":[321],"bathed":[325],"cocktail":[328],"containing":[329],"catalyzed":[334],"reaction.vi":[335]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}
