{"id":"https://openalex.org/W2299985447","doi":"https://doi.org/10.3390/molecules21030365","title":"Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine","display_name":"Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine","publication_year":2016,"publication_date":"2016-03-17","ids":{"openalex":"https://openalex.org/W2299985447","doi":"https://doi.org/10.3390/molecules21030365","mag":"2299985447","pmid":"https://pubmed.ncbi.nlm.nih.gov/26999092","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6274313"},"language":"en","primary_location":{"id":"doi:10.3390/molecules21030365","doi":"https://doi.org/10.3390/molecules21030365","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21030365","pdf_url":"https://www.mdpi.com/1420-3049/21/3/365/pdf?version=1458207307","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/21/3/365/pdf?version=1458207307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048454498","display_name":"Arkadiusz Marian Dziedzic","orcid":"https://orcid.org/0000-0003-0022-8382","observed_orcids":["https://orcid.org/0000-0003-0022-8382"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Arkadiusz Dziedzic","raw_affiliation_strings":["Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice, Pl. Akademicki 17, Bytom, 41-902, Poland"],"raw_orcid":"https://orcid.org/0000-0003-0022-8382","affiliations":[{"raw_affiliation_string":"Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice, Pl. Akademicki 17, Bytom, 41-902, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085711627","display_name":"Robert Kubina","orcid":"https://orcid.org/0000-0001-5462-2647","observed_orcids":["https://orcid.org/0000-0001-5462-2647"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Robert Kubina","raw_affiliation_strings":["Department and Institute of Pathology, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, ul. Ostrog\u00f3rska 30, Sosnowiec 41-200, Poland"],"raw_orcid":"https://orcid.org/0000-0001-5462-2647","affiliations":[{"raw_affiliation_string":"Department and Institute of Pathology, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, ul. Ostrog\u00f3rska 30, Sosnowiec 41-200, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029708397","display_name":"Rafa\u0142 Jakub Bu\u0142dak","orcid":"https://orcid.org/0000-0002-0405-0596","observed_orcids":["https://orcid.org/0000-0002-0405-0596"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafa\u0142 Bu\u0142dak","raw_affiliation_strings":["Department of Physiology, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice, ul. H. Jordana 19, Zabrze 41-808, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice, ul. H. Jordana 19, Zabrze 41-808, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041273923","display_name":"Magdalena Skonieczna","orcid":"https://orcid.org/0000-0002-6263-9585","observed_orcids":["https://orcid.org/0000-0002-6263-9585"]},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magda Skonieczna","raw_affiliation_strings":["Department of Automatic Control\u2014Biosystems Groups, Silesian University of Technology, Gliwice 44-100, Poland"],"raw_orcid":"https://orcid.org/0000-0002-6263-9585","affiliations":[{"raw_affiliation_string":"Department of Automatic Control\u2014Biosystems Groups, Silesian University of Technology, Gliwice 44-100, Poland","institution_ids":["https://openalex.org/I119004910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018197840","display_name":"Krzysztof Cholewa","orcid":"https://orcid.org/0000-0002-9687-2641","observed_orcids":["https://orcid.org/0000-0002-9687-2641"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Cholewa","raw_affiliation_strings":["Department of Biochemistry, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Sosnowiec 41-200, Poland"],"raw_orcid":"https://orcid.org/0000-0002-9687-2641","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Sosnowiec 41-200, Poland","institution_ids":["https://openalex.org/I166182418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048454498"],"corresponding_institution_ids":["https://openalex.org/I166182418"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":3.0799,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.91955567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"21","issue":"3","first_page":"365","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silver-nanoparticles","display_name":"silver nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scc-25-cells","display_name":"SCC-25 cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/plant-alkaloids","display_name":"plant alkaloids","score":0.6520000100135803},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7580000162124634},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5929999947547913},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.4580000042915344},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5180000066757202},{"id":"https://openalex.org/keywords/mtt-assay","display_name":"MTT assay","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.6499375700950623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6225030422210693},{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.5961227416992188},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5596101880073547},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.525567889213562},{"id":"https://openalex.org/C2994491419","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous carcinoma","level":3,"score":0.5143626928329468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4913100302219391},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4897420406341553},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4636038541793823},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4436176121234894},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4425259232521057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3997803032398224},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.28330618143081665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23462358117103577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23304876685142517},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.13332855701446533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13322722911834717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.130182683467865},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1284681260585785},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.12066614627838135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11673510074615479}],"mesh":[{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules21030365","doi":"https://doi.org/10.3390/molecules21030365","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21030365","pdf_url":"https://www.mdpi.com/1420-3049/21/3/365/pdf?version=1458207307","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5278663","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6274313","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6274313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6274313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:26999092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26999092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2321492db7a14a85a77b2f6dcc86d5b0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2321492db7a14a85a77b2f6dcc86d5b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 21, Iss 3, p 365 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules21030365","doi":"https://doi.org/10.3390/molecules21030365","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21030365","pdf_url":"https://www.mdpi.com/1420-3049/21/3/365/pdf?version=1458207307","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2299985447.pdf","grobid_xml":"https://content.openalex.org/works/W2299985447.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W852660276","https://openalex.org/W1973240521","https://openalex.org/W1981299193","https://openalex.org/W1989360626","https://openalex.org/W1989754098","https://openalex.org/W1991291235","https://openalex.org/W1991590198","https://openalex.org/W1992231291","https://openalex.org/W2013733164","https://openalex.org/W2020573863","https://openalex.org/W2022877129","https://openalex.org/W2038885144","https://openalex.org/W2041364796","https://openalex.org/W2043193448","https://openalex.org/W2044718938","https://openalex.org/W2048736765","https://openalex.org/W2051851983","https://openalex.org/W2052601846","https://openalex.org/W2056202999","https://openalex.org/W2058849119","https://openalex.org/W2059201273","https://openalex.org/W2066855216","https://openalex.org/W2075246879","https://openalex.org/W2093621244","https://openalex.org/W2107205997","https://openalex.org/W2111812837","https://openalex.org/W2113314086","https://openalex.org/W2115968506","https://openalex.org/W2136821155","https://openalex.org/W2139652646","https://openalex.org/W2146482929","https://openalex.org/W2148051364","https://openalex.org/W2149925561","https://openalex.org/W2150671975","https://openalex.org/W2164393253","https://openalex.org/W2167012615","https://openalex.org/W2168652718","https://openalex.org/W2312947897","https://openalex.org/W2334989887","https://openalex.org/W6677268649"],"related_works":["https://openalex.org/W3203680534","https://openalex.org/W6903832258","https://openalex.org/W2962453303","https://openalex.org/W4391531716","https://openalex.org/W3142891322","https://openalex.org/W3193944496","https://openalex.org/W2790366641","https://openalex.org/W4200596161","https://openalex.org/W2993742786","https://openalex.org/W4312684930"],"abstract_inverted_index":{"The":[0,99,209],"biological":[1],"activity":[2,101],"of":[3,20,23,33,50,62,84,102,106,142,161,187,217,238,244,260,296,298],"nanosize":[4,24],"silver":[5,26,70,156],"particles":[6,27,250],"towards":[7],"oral":[8,35,199,261],"epithelium-derived":[9],"carcinoma":[10,54,218,264],"seems":[11],"to":[12,69,77,81,139,213,270],"be":[13,277,288],"still":[14],"underinvestigated.":[15],"We":[16],"evaluated":[17],"the":[18,29,45,60,172,215,236,242,256,280],"influence":[19],"low":[21,252],"doses":[22,253],"scale":[25],"on":[28,196],"proliferation":[30,257],"and":[31,41,80,96,146,178,258],"viability":[32,259],"malignant":[34,198],"epithelial":[36,200],"keratinocytes":[37],"in":[38,42,175,246,291],"vitro,":[39],"alone":[40,72],"conjunction":[43],"with":[44,59,86,104,127,185,207,233],"plant":[46],"alkaloid":[47,282],"berberine.":[48],"Cells":[49],"human":[51],"tongue":[52],"squamous":[53,262],"SCC-25":[55,165,197,247,266],"(ATCC":[56],"CRL-1628),":[57],"cultivated":[58],"mixture":[61],"Dulbecco's":[63],"modified":[64],"Eagle's":[65],"medium,":[66],"were":[67],"exposed":[68],"nanoparticles":[71,157,286],"(AgNPs,":[73],"concentrations":[74],"from":[75,272],"0.31":[76],"10":[78,107,162],"\u03bcg/mL)":[79],"a":[82,159,176,292],"combination":[83],"AgNPs":[85,103,192,210,231],"berberine":[87],"chloride":[88],"(BER,":[89],"1/2":[90],"IC50":[91],"concentration)":[92],"during":[93],"24":[94],"h":[95,170,225],"48":[97,169,224],"h.":[98],"cytotoxic":[100,194],"diameters":[105],"nm":[108,111],"\u00b1":[109],"4":[110],"was":[112,122,137,226],"measured":[113],"by":[114,124,131,220,279,294],"3-(4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2H-tetrazolium":[115],"bromide":[116],"(MTT)":[117],"assay.":[118],"Cell":[119],"cycle":[120,167],"analysis":[121],"performed":[123],"treating":[125],"cells":[126,166,219,267],"propidium":[128],"iodide":[129],"followed":[130],"flow-activated":[132],"cell":[133,263],"sorting.":[134],"RT-QPCR":[135],"reaction":[136],"used":[138,290],"assess":[140],"expression":[141,237],"anti-apoptotic":[143],"proteins":[144],"Bcl-2":[145,239],"pro-apoptotic":[147],"protein":[148,151],"Bcl-2-associated":[149],"X":[150],"Bax":[152],"genes":[153],"expression.":[154,191],"Monodisperse":[155],"at":[158,171,228,251],"concentration":[160,211],"\u03bcg/mL":[163],"arrested":[164],"after":[168,223],"G0/G1":[173,183],"phase":[174],"dose-":[177],"time-dependent":[179],"manner":[180],"through":[181],"disruption":[182],"checkpoint,":[184],"increase":[186],"Bax/Bcl-2":[188,245],"ratio":[189,243],"gene":[190],"exhibit":[193],"effects":[195],"keratinocytes,":[201],"which":[202,275],"is":[203],"diminished":[204],"when":[205],"combined":[206,232],"BER.":[208],"required":[212],"inhibit":[214],"growth":[216],"50%":[221],"(IC50)":[222],"estimated":[227],"5.19":[229],"\u03bcg/mL.":[230],"BER":[234],"increased":[235],"while":[240],"decreasing":[241],"cells.":[248,265],"Silver":[249],"therefore":[254],"reduce":[255],"are":[268],"susceptible":[269],"damage":[271],"AgNPs-induced":[273],"stress,":[274],"can":[276],"regulated":[278],"natural":[281],"berberine,":[283],"suggesting":[284],"that":[285],"may":[287],"potentially":[289],"chemoprevention/chemotherapy":[293],"augmentation":[295],"action":[297],"standard":[299],"anti-cancer":[300],"drugs.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}