{"id":"https://openalex.org/W2299772952","doi":"https://doi.org/10.1021/acs.jmedchem.5b01200","title":"Evaluation of Improved Glycogen Synthase Kinase-3\u03b1 Inhibitors in Models of Acute Myeloid Leukemia","display_name":"Evaluation of Improved Glycogen Synthase Kinase-3\u03b1 Inhibitors in Models of Acute Myeloid Leukemia","publication_year":2015,"publication_date":"2015-10-23","ids":{"openalex":"https://openalex.org/W2299772952","doi":"https://doi.org/10.1021/acs.jmedchem.5b01200","mag":"2299772952","pmid":"https://pubmed.ncbi.nlm.nih.gov/26496242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883112"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.5b01200","doi":"https://doi.org/10.1021/acs.jmedchem.5b01200","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5b01200","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Theresa Neumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresa Neumann","raw_affiliation_strings":["Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040833467","display_name":"Lina Benajiba","orcid":"https://orcid.org/0000-0001-5440-1115","observed_orcids":["https://orcid.org/0000-0001-5440-1115"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Benajiba","raw_affiliation_strings":["Department\rof Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082434236","display_name":"Stefan G\u00f6ring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan G\u00f6ring","raw_affiliation_strings":["Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011985711","display_name":"Kimberly Stegmaier","orcid":"https://orcid.org/0000-0003-0218-7895","observed_orcids":["https://orcid.org/0000-0003-0218-7895"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Stegmaier","raw_affiliation_strings":["Department\rof Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085908396","display_name":"Boris Schmidt","orcid":"https://orcid.org/0000-0003-1662-2392","observed_orcids":["https://orcid.org/0000-0003-1662-2392"]},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Boris Schmidt","raw_affiliation_strings":["Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemens\rSch\u00f6pf Institute of Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085908396"],"corresponding_institution_ids":["https://openalex.org/I31512782"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3005,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7750774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"58","issue":"22","first_page":"8907","last_page":"8919"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.36250001192092896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.36250001192092896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.2295999974012375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3alpha","display_name":"glycogen synthase kinase-3\u03b1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/isoform-selective-inhibitors","display_name":"isoform-selective inhibitors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/zebrafish-embryo-toxicity","display_name":"zebrafish embryo toxicity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/leukemia-cell-differentiation","display_name":"leukemia cell differentiation","score":0.699999988079071},{"id":"https://openalex.org/keywords/colony-formation-inhibition","display_name":"colony formation inhibition","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7973690032958984},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.7779899835586548},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7435536980628967},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.5230618119239807},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49100640416145325},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.49033546447753906},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4835169315338135},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.4504580497741699},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43468883633613586},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37728410959243774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3613964915275574},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3555828034877777},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.33134031295776367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2732735574245453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14231139421463013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1355648636817932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10926827788352966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06709006428718567}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1021/acs.jmedchem.5b01200","doi":"https://doi.org/10.1021/acs.jmedchem.5b01200","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5b01200","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:26496242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26496242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:oceanrep.geomar.de:31851","doi":null,"is_oa":false,"landing_page_url":"http://oceanrep.geomar.de/31851/1/Neumann.pdf","pdf_url":"http://oceanrep.geomar.de/31851/1/Neumann.pdf","source":{"id":"https://openalex.org/S4306400264","display_name":"Helmholtz Centre for Ocean Research Kiel (GEOMAR)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34403800","host_organization_name":"GEOMAR Helmholtz Centre for Ocean Research Kiel","host_organization_lineage":["https://openalex.org/I34403800"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry, 58 (22). pp. 8907-8919.","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:3848244","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883112","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4883112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883112","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmh:oai:tuprints.ulb.tu-darmstadt.de:9652","doi":null,"is_oa":true,"landing_page_url":"http://tuprints.ulb.tu-darmstadt.de/view/person/Neumann=3ATheresa=3A=3A.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4306401590","display_name":"Technischen Universit\u00e4t Darmstadt","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/workingPaper"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:118213","doi":null,"is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/118213/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artikel"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:146234","doi":null,"is_oa":true,"landing_page_url":"https://tuprints.ulb.tu-darmstadt.de/9652","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Report"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:146440","doi":null,"is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/146440/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artikel"},{"id":"doi:10.25534/tuprints-00009652","doi":"https://doi.org/10.25534/tuprints-00009652","is_oa":true,"landing_page_url":"https://doi.org/10.25534/tuprints-00009652","pdf_url":null,"source":{"id":"https://openalex.org/S7407053004","display_name":"TUdigit","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405263218","host_organization_name":"Universit\u00e4ts- und Landesbibliothek Darmstadt","host_organization_lineage":["https://openalex.org/I4405263218"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3848244","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883112","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4223276157","display_name":"Validating Syk as a Target for AML Therapy","funder_award_id":"R01CA140292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320329738","display_name":"Hans und Ilse Breuer-Stiftung","ror":"https://ror.org/02cmgf628"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1583736594","https://openalex.org/W1716978847","https://openalex.org/W1963561816","https://openalex.org/W1964378600","https://openalex.org/W1964631519","https://openalex.org/W1968904120","https://openalex.org/W1983055247","https://openalex.org/W1986961354","https://openalex.org/W1998568556","https://openalex.org/W2031443046","https://openalex.org/W2062934426","https://openalex.org/W2064913654","https://openalex.org/W2065651024","https://openalex.org/W2068995330","https://openalex.org/W2083308747","https://openalex.org/W2090013938","https://openalex.org/W2119584760","https://openalex.org/W2121745326","https://openalex.org/W2127004861","https://openalex.org/W2146222121","https://openalex.org/W2167928721"],"related_works":["https://openalex.org/W2031443046","https://openalex.org/W2924873869","https://openalex.org/W2574828325","https://openalex.org/W2790098035","https://openalex.org/W2388625588","https://openalex.org/W4321488198","https://openalex.org/W4409257622","https://openalex.org/W2559505757","https://openalex.org/W4241237045","https://openalex.org/W2235924786"],"abstract_inverted_index":{"The":[0,20,36],"challenge":[1],"for":[2,14,97],"glycogen":[3],"synthase":[4],"kinase-3":[5],"(GSK-3)":[6],"inhibitor":[7],"design":[8],"lies":[9],"in":[10,101,110,120,135],"achieving":[11],"high":[12,81],"selectivity":[13,49,89],"one":[15],"isoform":[16],"over":[17],"the":[18,46,62,86,130],"other.":[19],"therapy":[21],"of":[22,65,132],"certain":[23],"diseases,":[24],"such":[25],"as":[26],"acute":[27],"myeloid":[28],"leukemia":[29],"(AML),":[30],"may":[31],"require":[32],"\u03b1-isoform":[33],"specific":[34],"targeting.":[35],"scorpion":[37,71],"shaped":[38,72],"GSK-3":[39],"inhibitors":[40,68],"developed":[41],"by":[42],"our":[43,66],"group":[44],"achieved":[45,115],"highest":[47,87],"GSK-3\u03b1":[48,88,108,133],"reported":[50,90],"so":[51],"far":[52],"but":[53],"suffered":[54],"from":[55],"insufficient":[56],"aqueous":[57],"solubility.":[58],"This":[59],"work":[60],"presents":[61],"solubility-driven":[63],"optimization":[64],"isoform-selective":[67],"using":[69],"a":[70,102,121],"lead.":[73],"Among":[74],"15":[75],"novel":[76],"compounds,":[77],"compound":[78,117],"27":[79,94],"showed":[80],"activity":[82],"against":[83],"GSK-3\u03b1/\u03b2":[84],"with":[85,116],"to":[91],"date.":[92],"Compound":[93],"was":[95,114],"profiled":[96],"bioavailability":[98],"and":[99,125],"toxicity":[100],"zebrafish":[103],"embryo":[104],"phenotype":[105,124],"assay.":[106],"Selective":[107],"targeting":[109],"AML":[111,136],"cell":[112],"lines":[113],"27,":[118],"resulting":[119],"strong":[122],"differentiation":[123],"colony":[126],"formation":[127],"impairment,":[128],"confirming":[129],"potential":[131],"inhibition":[134],"therapy.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}