{"id":"https://openalex.org/W2299706972","doi":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","title":"Norepinephrine release in isolated arteries induced by K-free solution","display_name":"Norepinephrine release in isolated arteries induced by K-free solution","publication_year":1977,"publication_date":"1977-02-01","ids":{"openalex":"https://openalex.org/W2299706972","doi":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","mag":"2299706972","pmid":"https://pubmed.ncbi.nlm.nih.gov/842645"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1977.232.2.h140","doi":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068422292","display_name":"AURORA BONACCORSI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Bonaccorsi","raw_affiliation_strings":["","\u2020University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"\u2020University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078322142","display_name":"Kent Hermsmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Hermsmeyer","raw_affiliation_strings":["","\u2020University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"\u2020University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. B. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. B. Smith","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067553501","display_name":"David F. Bohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. F. Bohr","raw_affiliation_strings":["","\u2020University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"\u2020University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7661,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.91535231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"232","issue":"2","first_page":"H140","last_page":"H145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.9990000128746033},{"id":"https://openalex.org/keywords/potassium-free-solution","display_name":"potassium-free solution","score":0.777999997138977},{"id":"https://openalex.org/keywords/sympathetic-innervation","display_name":"sympathetic innervation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.6880000233650208},{"id":"https://openalex.org/keywords/na-k-atpase-inhibition","display_name":"Na+/K+-ATPase inhibition","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.8460000157356262},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.9010000228881836},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adrenergic-nerves","display_name":"adrenergic nerves","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neurogenic-vasoconstriction","display_name":"neurogenic vasoconstriction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mesenteric-arteries","display_name":"mesenteric arteries","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tail-artery","display_name":"tail artery","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.7429345846176147},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.5786574482917786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5781588554382324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5643877983093262},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5449984073638916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5434605479240417},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.5192654132843018},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.5174806118011475},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.5024292469024658},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.486594557762146},{"id":"https://openalex.org/C2776937108","wikidata":"https://www.wikidata.org/wiki/Q1480291","display_name":"Contracture","level":2,"score":0.46535807847976685},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4514181315898895},{"id":"https://openalex.org/C2779723990","wikidata":"https://www.wikidata.org/wiki/Q707174","display_name":"Femoral artery","level":2,"score":0.41047701239585876},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.3923277258872986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29778793454170227},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.1546941101551056},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.11064472794532776},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10471227765083313},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09446975588798523},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005263","descriptor_name":"Femoral Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006892","descriptor_name":"Hydroxydopamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013623","descriptor_name":"Tail","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1977.232.2.h140","doi":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1977.232.2.h140","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:842645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/842645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2318396751","https://openalex.org/W2082538682","https://openalex.org/W1975056600","https://openalex.org/W2943064175","https://openalex.org/W2397307455","https://openalex.org/W1842480584","https://openalex.org/W1946420270","https://openalex.org/W2565787071","https://openalex.org/W1994460584","https://openalex.org/W1978874226"],"abstract_inverted_index":{"Helical":[0,63],"strips":[1,64],"from":[2],"arteries":[3,42,68,72],"with":[4,49,146],"a":[5,18,24,84,105,128],"rich":[6],"sympathetic":[7],"innervation":[8],"(rat":[9],"tail":[10,67],"and":[11,13,37,57,91,113],"femoral,":[12],"dog":[14,70],"mesenteric":[15,71],"arteries)":[16],"develop":[17],"sustained":[19],"contracture":[20,31,135],"when":[21],"exposed":[22],"to":[23,83,104],"K-free":[25,106,134],"physiological":[26],"salt":[27],"solution":[28],"(PSS).":[29],"The":[30,51],"can":[32],"be":[33],"blocked":[34],"by":[35,118,153],"phentolamine":[36],"does":[38],"not":[39],"occur":[40],"in":[41,75,132,144],"whose":[43],"nerve":[44],"terminals":[45],"have":[46],"been":[47],"destroyed":[48],"6-hydroxydopamine.":[50],"temporal":[52],"relationship":[53],"between":[54],"force":[55,108],"development":[56,109],"efflux":[58],"of":[59,65,93,99,136,158],"NE":[60,111,150],"was":[61],"determined.":[62],"rat":[66],"or":[69],"were":[73,80,116],"incubated":[74],"PSS":[76,107],"containing":[77],"1-norepinephrine-7-3H([3H]NE).":[78],"They":[79],"then":[81],"transferred":[82],"superfusion":[85],"system":[86],"which":[87],"allowed":[88],"isometric":[89],"recordings":[90],"collection":[92],"the":[94,97,133,137,147],"superfusate":[95],"for":[96],"estimation":[98],"[3H]NE":[100],"content.":[101],"Following":[102],"exposure":[103],"paralleled":[110],"release":[112],"both":[114],"parameters":[115],"potentiated":[117],"ouabain.":[119],"These":[120],"data":[121],"demonstrate":[122],"that":[123,149],"this":[124],"neurogenic":[125],"mechanism":[126],"plays":[127],"most":[129],"important":[130],"role":[131],"vascular":[138],"smooth":[139],"muscle":[140],"studied.":[141],"It":[142],"is":[143,151],"accord":[145],"observation":[148],"released":[152],"adrenergic":[154],"nerves":[155],"following":[156],"inhibition":[157],"Na+-K+-ATPase.":[159]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}