{"id":"https://openalex.org/W2299554199","doi":"https://doi.org/10.7326/m15-1456","title":"Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy","display_name":"Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2299554199","doi":"https://doi.org/10.7326/m15-1456","mag":"2299554199","pmid":"https://pubmed.ncbi.nlm.nih.gov/26830221"},"language":"en","primary_location":{"id":"doi:10.7326/m15-1456","doi":"https://doi.org/10.7326/m15-1456","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m15-1456","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044599092","display_name":"Rathan M. Subramaniam","orcid":"https://orcid.org/0000-0003-3973-4610","observed_orcids":["https://orcid.org/0000-0003-3973-4610","https://orcid.org/0000-0001-9417-0649"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rathan M. Subramaniam","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070778528","display_name":"Catalina Suarez\u2010Cuervo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catalina Suarez-Cuervo","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062226918","display_name":"Ren\u00e9e F Wilson","orcid":"https://orcid.org/0000-0003-0786-1017","observed_orcids":["https://orcid.org/0000-0003-0786-1017"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee F. Wilson","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067986631","display_name":"Sharon Turban","orcid":"https://orcid.org/0009-0004-4635-7504","observed_orcids":["https://orcid.org/0009-0004-4635-7504"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Turban","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101462305","display_name":"Allen W. Zhang","orcid":"https://orcid.org/0000-0001-9455-866X","observed_orcids":["https://orcid.org/0000-0001-9455-866X","https://orcid.org/0000-0002-7606-089X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Zhang","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039933928","display_name":"Cheryl E. Sherrod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Sherrod","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075390989","display_name":"Jonathan Aboagye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Aboagye","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011766637","display_name":"John Eng","orcid":"https://orcid.org/0000-0002-9129-5160","observed_orcids":["https://orcid.org/0000-0002-9129-5160"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Eng","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102172743","display_name":"Michael Jin Choi","orcid":"https://orcid.org/0009-0005-1210-3466","observed_orcids":["https://orcid.org/0009-0005-1210-3466"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Choi","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051473333","display_name":"Susan M. Hutfless","orcid":"https://orcid.org/0000-0002-6311-2611","observed_orcids":["https://orcid.org/0000-0002-6311-2611"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Hutfless","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056638016","display_name":"Eric B Bass","orcid":"https://orcid.org/0000-0001-9106-527X","observed_orcids":["https://orcid.org/0000-0001-9106-527X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric B. Bass","raw_affiliation_strings":["From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University Evidence-based Practice Center, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":31.1796,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.99824621,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"164","issue":"6","first_page":"406","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contrast-induced-nephropathy","display_name":"contrast-induced nephropathy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sodium-bicarbonate","display_name":"sodium bicarbonate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/contrast-media","display_name":"contrast media","score":0.777999997138977},{"id":"https://openalex.org/keywords/low-osmolality-contrast-media","display_name":"low-osmolar contrast media","score":0.949999988079071},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6119999885559082},{"id":"https://openalex.org/keywords/intravenous-saline","display_name":"intravenous saline","score":0.609000027179718},{"id":"https://openalex.org/keywords/cardiac-events","display_name":"cardiac events","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9760000109672546},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.6359999775886536},{"id":"https://openalex.org/keywords/prevention","display_name":"prevention","score":0.4320000112056732},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.38199999928474426},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8858221769332886},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.74867844581604},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.6653517484664917},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.6638264656066895},{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.6465462446212769},{"id":"https://openalex.org/C2778569047","wikidata":"https://www.wikidata.org/wiki/Q1783300","display_name":"Contrast-induced nephropathy","level":4,"score":0.5559772253036499},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5171625018119812},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4119090437889099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.392663836479187},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3394808769226074},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.2779127359390259},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15418797731399536},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.06942161917686462},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0537700355052948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7326/m15-1456","doi":"https://doi.org/10.7326/m15-1456","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m15-1456","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:26830221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26830221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W62949817","https://openalex.org/W75293357","https://openalex.org/W153688073","https://openalex.org/W207632514","https://openalex.org/W1492385672","https://openalex.org/W1494328843","https://openalex.org/W1502920150","https://openalex.org/W1535720050","https://openalex.org/W1697737316","https://openalex.org/W1755047871","https://openalex.org/W1766335371","https://openalex.org/W1790120012","https://openalex.org/W1932229822","https://openalex.org/W1964636235","https://openalex.org/W1975696059","https://openalex.org/W1977428646","https://openalex.org/W1983463589","https://openalex.org/W1984282912","https://openalex.org/W1984903215","https://openalex.org/W1985871358","https://openalex.org/W1990701898","https://openalex.org/W1993529737","https://openalex.org/W1996020381","https://openalex.org/W1997186363","https://openalex.org/W1998899450","https://openalex.org/W1998969033","https://openalex.org/W2000043063","https://openalex.org/W2000681707","https://openalex.org/W2002332553","https://openalex.org/W2005801539","https://openalex.org/W2005849560","https://openalex.org/W2009174838","https://openalex.org/W2010759815","https://openalex.org/W2014542372","https://openalex.org/W2015127891","https://openalex.org/W2016497044","https://openalex.org/W2019620257","https://openalex.org/W2020280677","https://openalex.org/W2020675649","https://openalex.org/W2022852834","https://openalex.org/W2023663195","https://openalex.org/W2026274122","https://openalex.org/W2030003928","https://openalex.org/W2033054726","https://openalex.org/W2033442603","https://openalex.org/W2034829698","https://openalex.org/W2038454530","https://openalex.org/W2038906798","https://openalex.org/W2040205763","https://openalex.org/W2041228076","https://openalex.org/W2043321959","https://openalex.org/W2044487819","https://openalex.org/W2046590737","https://openalex.org/W2054817867","https://openalex.org/W2054893906","https://openalex.org/W2055003585","https://openalex.org/W2056699268","https://openalex.org/W2060435772","https://openalex.org/W2063605280","https://openalex.org/W2064986876","https://openalex.org/W2066574629","https://openalex.org/W2069585458","https://openalex.org/W2073403364","https://openalex.org/W2076170077","https://openalex.org/W2079433011","https://openalex.org/W2080339046","https://openalex.org/W2080947535","https://openalex.org/W2086977066","https://openalex.org/W2088811748","https://openalex.org/W2090132603","https://openalex.org/W2091298323","https://openalex.org/W2095441459","https://openalex.org/W2096277043","https://openalex.org/W2103136786","https://openalex.org/W2104789778","https://openalex.org/W2109909502","https://openalex.org/W2109932276","https://openalex.org/W2113101136","https://openalex.org/W2117721489","https://openalex.org/W2127916098","https://openalex.org/W2129670822","https://openalex.org/W2130073437","https://openalex.org/W2130266388","https://openalex.org/W2133923659","https://openalex.org/W2141271021","https://openalex.org/W2143687264","https://openalex.org/W2144452952","https://openalex.org/W2145479602","https://openalex.org/W2146459370","https://openalex.org/W2152105052","https://openalex.org/W2152135127","https://openalex.org/W2152497726","https://openalex.org/W2159974891","https://openalex.org/W2161089842","https://openalex.org/W2165936931","https://openalex.org/W2169871046","https://openalex.org/W2170066707","https://openalex.org/W2180241986","https://openalex.org/W2187109815","https://openalex.org/W2219634061","https://openalex.org/W2252398476","https://openalex.org/W2316707066","https://openalex.org/W2325803365","https://openalex.org/W2327454703","https://openalex.org/W2328033304","https://openalex.org/W2329461066","https://openalex.org/W2330000101","https://openalex.org/W2408914567","https://openalex.org/W2418994593","https://openalex.org/W2548894639","https://openalex.org/W2799129279"],"related_works":["https://openalex.org/W2161441452","https://openalex.org/W2337145592","https://openalex.org/W2610087566","https://openalex.org/W1518667173","https://openalex.org/W3132933390","https://openalex.org/W2054893906","https://openalex.org/W2239407816","https://openalex.org/W2019620257","https://openalex.org/W1998498941","https://openalex.org/W2472560723"],"abstract_inverted_index":{"BACKGROUND:":[0],"N-acetylcysteine,":[1,64],"sodium":[2,65,183],"bicarbonate,":[3,66],"statins,":[4,67],"and":[5,39,48,79,94,142,165,217,247,278,293],"ascorbic":[6,69,218],"acid":[7,70,219],"have":[8],"been":[9],"studied":[10],"for":[11,85,237,242,290],"reducing":[12],"contrast-induced":[13],"nephropathy":[14],"(CIN).":[15],"PURPOSE:":[16],"To":[17],"evaluate":[18],"the":[19,240],"comparative":[20],"effectiveness":[21],"of":[22,46,51,54,63,232,239],"interventions":[23],"to":[24,116,138,158,198,213,227],"reduce":[25],"CIN":[26,81,266],"in":[27,128,188,255,265,274],"adults":[28],"receiving":[29,130,190,257,276],"contrast":[30,77,132,192,259],"media.":[31,260],"DATA":[32,87,98],"SOURCES:":[33],"MEDLINE,":[34],"EMBASE,":[35],"Cochrane":[36],"Library,":[37],"ClinicalTrials.gov,":[38],"Scopus":[40],"databases":[41],"through":[42],"June":[43],"2015.":[44],"Risk":[45],"bias":[47],"overall":[49],"strength":[50],"evidence":[52,233],"(SOE)":[53],"studies":[55,252],"were":[56,253],"assessed.":[57],"STUDY":[58],"SELECTION:":[59],"Randomized,":[60],"controlled":[61],"trials":[62],"or":[68,75],"that":[71,178],"used":[72],"intravenous":[73],"(IV)":[74],"intra-arterial":[76],"media":[78,133,193],"defined":[80],"with":[82,106,125,269,279],"enough":[83],"data":[84,93],"meta-analysis.":[86],"EXTRACTION:":[88],"Two":[89],"reviewers":[90],"independently":[91],"extracted":[92],"assessed":[95],"study":[96],"quality.":[97],"SYNTHESIS:":[99],"Low-dose":[100],"N-acetylcysteine":[101,120,145,150,270,282],"plus":[102,121,144,146,151,203,271,281,283],"IV":[103,107,122,126,147,152,186,204,207,221,258,272,284],"saline":[104,108,123,127,148,153,187,205,208,222,273],"compared":[105,124],"(risk":[109],"ratio":[110],"[RR],":[111],"0.75":[112],"[95%":[113],"CI,":[114],"0.63":[115],"0.89];":[117],"low":[118,160,200,215,229],"SOE),":[119,141,201,216],"patients":[129,189,256,275],"low-osmolar":[131,191],"(RR,":[134,154,194,209,223],"0.69":[135],"[CI,":[136,156,196,211,225],"0.58":[137],"0.84];":[139],"moderate":[140],"statins":[143,202,280],"versus":[149,185,206,220],"0.52":[155],"0.29":[157],"0.93];":[159],"SOE)":[161],"had":[162],"clinically":[163,175],"important":[164,176],"statistically":[166,181],"significant":[167],"benefits.":[168],"The":[169,262],"following":[170],"3":[171],"comparisons":[172,238],"suggested":[173],"a":[174],"difference":[177],"was":[179,234,267],"not":[180],"significant:":[182],"bicarbonate":[184],"0.65":[195],"0.33":[197],"1.25];":[199],"0.68":[210],"0.39":[212],"1.20];":[214],"0.72":[224],"0.48":[226],"1.01];":[228],"SOE).":[230],"Strength":[231],"generally":[235],"insufficient":[236],"need":[241],"renal":[243],"replacement,":[244],"cardiac":[245],"events,":[246],"mortality.":[248],"LIMITATION:":[249],"Too":[250],"few":[251],"done":[254],"CONCLUSION:":[261],"greatest":[263],"reduction":[264],"seen":[268],"LOCM":[277],"saline.":[285],"PRIMARY":[286],"FUNDING":[287],"SOURCE:":[288],"Agency":[289],"Healthcare":[291],"Research":[292],"Quality.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}