{"id":"https://openalex.org/W2299433408","doi":"https://doi.org/10.1007/s12035-016-9722-8","title":"Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis","display_name":"Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis","publication_year":2016,"publication_date":"2016-01-27","ids":{"openalex":"https://openalex.org/W2299433408","doi":"https://doi.org/10.1007/s12035-016-9722-8","mag":"2299433408","pmid":"https://pubmed.ncbi.nlm.nih.gov/26820674"},"language":"en","primary_location":{"id":"doi:10.1007/s12035-016-9722-8","doi":"https://doi.org/10.1007/s12035-016-9722-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12035-016-9722-8","pdf_url":null,"source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001559844","display_name":"Vandana Rai","orcid":"https://orcid.org/0000-0001-8590-9675","observed_orcids":["https://orcid.org/0000-0001-8590-9675"]},"institutions":[{"id":"https://openalex.org/I875728190","display_name":"Veer Bahadur Singh Purvanchal University","ror":"https://ror.org/0560jvm78","country_code":"IN","type":"education","lineage":["https://openalex.org/I875728190"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vandana Rai","raw_affiliation_strings":["Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, 222003, UP, India. raivandana@rediffmail.com","Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, 222003, UP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, 222003, UP, India. raivandana@rediffmail.com","institution_ids":["https://openalex.org/I875728190"]},{"raw_affiliation_string":"Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, 222003, UP, India","institution_ids":["https://openalex.org/I875728190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001559844"],"corresponding_institution_ids":["https://openalex.org/I875728190"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.4233,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.80187874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"54","issue":"2","first_page":"1173","last_page":"1186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9729999899864197},{"id":"https://openalex.org/keywords/folate-pathway","display_name":"folate pathway","score":0.859000027179718},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9542295336723328},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7555961608886719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6722760200500488},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5994727611541748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5982177257537842},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5502335429191589},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5419356226921082},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.5236994028091431},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.48740556836128235},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3733627200126648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29118043184280396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18938258290290833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1124807596206665}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12035-016-9722-8","doi":"https://doi.org/10.1007/s12035-016-9722-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12035-016-9722-8","pdf_url":null,"source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},{"id":"pmid:26820674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26820674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W24088030","https://openalex.org/W31447801","https://openalex.org/W74077904","https://openalex.org/W968487728","https://openalex.org/W1519977277","https://openalex.org/W1521222329","https://openalex.org/W1580569750","https://openalex.org/W1599690748","https://openalex.org/W1925208328","https://openalex.org/W1940705123","https://openalex.org/W1945836171","https://openalex.org/W1963740601","https://openalex.org/W1964104737","https://openalex.org/W1964435302","https://openalex.org/W1976599343","https://openalex.org/W1979423827","https://openalex.org/W1982342644","https://openalex.org/W1984266094","https://openalex.org/W1984270090","https://openalex.org/W1991176673","https://openalex.org/W1992174426","https://openalex.org/W1996855564","https://openalex.org/W1998003446","https://openalex.org/W1999415788","https://openalex.org/W2003334814","https://openalex.org/W2005297096","https://openalex.org/W2014643072","https://openalex.org/W2015428626","https://openalex.org/W2022182003","https://openalex.org/W2022635031","https://openalex.org/W2025012927","https://openalex.org/W2026274413","https://openalex.org/W2027608000","https://openalex.org/W2034507578","https://openalex.org/W2034750558","https://openalex.org/W2036250027","https://openalex.org/W2037081589","https://openalex.org/W2038687374","https://openalex.org/W2045598383","https://openalex.org/W2051484514","https://openalex.org/W2051847073","https://openalex.org/W2052211882","https://openalex.org/W2052588755","https://openalex.org/W2053958748","https://openalex.org/W2054476774","https://openalex.org/W2054722639","https://openalex.org/W2057042201","https://openalex.org/W2057472210","https://openalex.org/W2058040995","https://openalex.org/W2062858052","https://openalex.org/W2066603606","https://openalex.org/W2067034692","https://openalex.org/W2074201510","https://openalex.org/W2075555698","https://openalex.org/W2075794182","https://openalex.org/W2079919793","https://openalex.org/W2080145783","https://openalex.org/W2081532048","https://openalex.org/W2086331691","https://openalex.org/W2090268945","https://openalex.org/W2091492880","https://openalex.org/W2092735546","https://openalex.org/W2099556509","https://openalex.org/W2103953940","https://openalex.org/W2107328434","https://openalex.org/W2108726143","https://openalex.org/W2115680280","https://openalex.org/W2116321557","https://openalex.org/W2116950438","https://openalex.org/W2122522567","https://openalex.org/W2124621777","https://openalex.org/W2125718465","https://openalex.org/W2126930838","https://openalex.org/W2131796019","https://openalex.org/W2143296193","https://openalex.org/W2145693405","https://openalex.org/W2146280876","https://openalex.org/W2150000105","https://openalex.org/W2152907424","https://openalex.org/W2157823046","https://openalex.org/W2157862480","https://openalex.org/W2164732692","https://openalex.org/W2165715420","https://openalex.org/W2170959965","https://openalex.org/W2315123323","https://openalex.org/W2355279198","https://openalex.org/W2386394558","https://openalex.org/W2588681363","https://openalex.org/W3028604940"],"related_works":["https://openalex.org/W2209324532","https://openalex.org/W2072559745","https://openalex.org/W2057472210","https://openalex.org/W2080206297","https://openalex.org/W2370610949","https://openalex.org/W2036250027","https://openalex.org/W2037081589","https://openalex.org/W2908790941","https://openalex.org/W2005297096","https://openalex.org/W2115680280"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
