{"id":"https://openalex.org/W2299171920","doi":"https://doi.org/10.1007/978-4-431-55763-0_20","title":"Biomarkers in Alzheimer\u2019s Disease: From Pathogenic Initiation to Downstream Outcomes","display_name":"Biomarkers in Alzheimer\u2019s Disease: From Pathogenic Initiation to Downstream Outcomes","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2299171920","doi":"https://doi.org/10.1007/978-4-431-55763-0_20","mag":"2299171920"},"language":"en","primary_location":{"id":"doi:10.1007/978-4-431-55763-0_20","doi":"https://doi.org/10.1007/978-4-431-55763-0_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-4-431-55763-0_20","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Mechanisms","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2411297811","display_name":"Aging Mechanisms"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111939423","display_name":"Sun-Ho Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun-Ho Han","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721989","display_name":"Jong\u2010Chan Park","orcid":"https://orcid.org/0000-0001-7516-7292","observed_orcids":["https://orcid.org/0000-0001-7516-7292","https://orcid.org/0000-0003-3766-7274"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Chan Park","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029374567","display_name":"Inhee Mook\u2010Jung","orcid":"https://orcid.org/0000-0001-7085-4085","observed_orcids":["https://orcid.org/0000-0001-7085-4085"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Inhee Mook-Jung","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029374567"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15544218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"341","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8519999980926514},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9710000157356262},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immunological-biomarkers","display_name":"immunological biomarkers","score":0.8740000128746033},{"id":"https://openalex.org/keywords/genetic-profiling","display_name":"genetic profiling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuropathological-mechanisms","display_name":"neuropathological mechanisms","score":0.734000027179718},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.42100000381469727},{"id":"https://openalex.org/keywords/clinical-trial-failure","display_name":"clinical trial failure","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.6645715236663818},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5792151689529419},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40574029088020325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36744606494903564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3407233953475952},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33466464281082153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22197726368904114},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12898430228233337},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.06643640995025635}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-4-431-55763-0_20","doi":"https://doi.org/10.1007/978-4-431-55763-0_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-4-431-55763-0_20","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Mechanisms","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1485638561","https://openalex.org/W1506822111","https://openalex.org/W1508811801","https://openalex.org/W1585653286","https://openalex.org/W1598703170","https://openalex.org/W1636456397","https://openalex.org/W1964869332","https://openalex.org/W1964927978","https://openalex.org/W1971271037","https://openalex.org/W1974326834","https://openalex.org/W1975034623","https://openalex.org/W1978219957","https://openalex.org/W1986300349","https://openalex.org/W1986624196","https://openalex.org/W1992901525","https://openalex.org/W2003833794","https://openalex.org/W2006289803","https://openalex.org/W2007044705","https://openalex.org/W2010708557","https://openalex.org/W2012076586","https://openalex.org/W2017260345","https://openalex.org/W2017419067","https://openalex.org/W2023288318","https://openalex.org/W2023641365","https://openalex.org/W2028109065","https://openalex.org/W2032212934","https://openalex.org/W2036362108","https://openalex.org/W2044788039","https://openalex.org/W2058838468","https://openalex.org/W2060212076","https://openalex.org/W2061576298","https://openalex.org/W2062135776","https://openalex.org/W2063414869","https://openalex.org/W2066450419","https://openalex.org/W2071715200","https://openalex.org/W2075605386","https://openalex.org/W2078123230","https://openalex.org/W2080688622","https://openalex.org/W2080946103","https://openalex.org/W2082399023","https://openalex.org/W2085901265","https://openalex.org/W2091320827","https://openalex.org/W2094761283","https://openalex.org/W2096410114","https://openalex.org/W2098946684","https://openalex.org/W2108818213","https://openalex.org/W2114684542","https://openalex.org/W2116784956","https://openalex.org/W2124490243","https://openalex.org/W2125629287","https://openalex.org/W2129771097","https://openalex.org/W2144803285","https://openalex.org/W2145965569","https://openalex.org/W2147576743","https://openalex.org/W2152119060","https://openalex.org/W2167720733","https://openalex.org/W2312423307","https://openalex.org/W4249565903"],"related_works":["https://openalex.org/W3036627511","https://openalex.org/W4417429445","https://openalex.org/W4403674279","https://openalex.org/W7061005659","https://openalex.org/W2913805969","https://openalex.org/W2382621607","https://openalex.org/W7096775342","https://openalex.org/W4225146920","https://openalex.org/W2997348249","https://openalex.org/W1746809319"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
