{"id":"https://openalex.org/W2299168099","doi":"https://doi.org/10.2119/molmed.2015.00250","title":"Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2","display_name":"Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2299168099","doi":"https://doi.org/10.2119/molmed.2015.00250","mag":"2299168099","pmid":"https://pubmed.ncbi.nlm.nih.gov/26982513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004715"},"language":"en","primary_location":{"id":"doi:10.2119/molmed.2015.00250","doi":"https://doi.org/10.2119/molmed.2015.00250","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00250","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00250","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00250","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhaoxia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoxia Zhang","raw_affiliation_strings":["Department of Pediatrics, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenjun Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Deng","raw_affiliation_strings":["Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091664811","display_name":"Rui Kang","orcid":"https://orcid.org/0000-0003-2725-1574","observed_orcids":["https://orcid.org/0000-0003-2725-1574"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Kang","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101925603","display_name":"Min Xie","orcid":"https://orcid.org/0000-0002-1338-0044","observed_orcids":["https://orcid.org/0000-0002-1338-0044"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xie","raw_affiliation_strings":["Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062076820","display_name":"Timothy R. Billiar","orcid":"https://orcid.org/0000-0002-2949-0811","observed_orcids":["https://orcid.org/0000-0002-2949-0811"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Billiar","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452906","display_name":"Haichao Wang","orcid":"https://orcid.org/0000-0002-0211-9000","observed_orcids":["https://orcid.org/0000-0002-0211-9000"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haichao Wang","raw_affiliation_strings":["Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America","Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, Manhasset, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, Manhasset, New York, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010188","display_name":"Lizhi Cao","orcid":"https://orcid.org/0000-0003-3725-0057","observed_orcids":["https://orcid.org/0000-0003-3725-0057"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lizhi Cao","raw_affiliation_strings":["Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055468442","display_name":"Daolin Tang","orcid":"https://orcid.org/0000-0002-1903-6180","observed_orcids":["https://orcid.org/0000-0002-1903-6180","https://orcid.org/0000-0002-2650-3816"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Daolin Tang","raw_affiliation_strings":["Center for DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China","Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210092091"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, G.27C, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, Pennsylvania, 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5103010188"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":3.7464,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94218369,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"162","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plumbagin","display_name":"plumbagin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.7760000228881836},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.796999990940094},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.796999990940094},{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.6859999895095825},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/naphthoquinones","display_name":"naphthoquinones","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C2780532915","wikidata":"https://www.wikidata.org/wiki/Q2550553","display_name":"Plumbagin","level":2,"score":0.9360884428024292},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7314362525939941},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.6379989385604858},{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.5616464018821716},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5396063923835754},{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.5137954354286194},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.465711385011673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43749797344207764},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.4293053150177002},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4164980947971344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3311537504196167},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.3193570673465729},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3140164613723755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30186647176742554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24120286107063293},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.23360595107078552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2217302918434143},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2119/molmed.2015.00250","doi":"https://doi.org/10.2119/molmed.2015.00250","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00250","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00250","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3978519","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004715","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5004715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med","raw_type":"Text"},{"id":"pmid:26982513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26982513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine (Cambridge, Mass.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d80491b9387a45eeb0179f84a1e043ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d80491b9387a45eeb0179f84a1e043ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine, Vol 22, Iss 1, Pp 162-172 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2119/molmed.2015.00250","doi":"https://doi.org/10.2119/molmed.2015.00250","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00250","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00250","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1482889761","display_name":"Immunometabolism in Sepsis","funder_award_id":"R01GM115366","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2495558488","display_name":"Mitophagy in Tumor Microenvironment","funder_award_id":"R01CA160417","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4319723488","display_name":"Nitric Oxide and Hepatic Function in Sepsis and Trauma","funder_award_id":"R01GM044100","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4436016543","display_name":null,"funder_award_id":"R01CA160417","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G4729744812","display_name":"Regulation of HMGB1 Release in Endotoxemia.","funder_award_id":"R01GM063075","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5130743199","display_name":"Mechanisms of Novel Herbal Therapies for Sepsis.","funder_award_id":"R01AT005076","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G7247333265","display_name":null,"funder_award_id":"R01GM115366","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2299168099.pdf","grobid_xml":"https://content.openalex.org/works/W2299168099.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W83032507","https://openalex.org/W1558505280","https://openalex.org/W1952221220","https://openalex.org/W1967680980","https://openalex.org/W1970400427","https://openalex.org/W1971661335","https://openalex.org/W1976455881","https://openalex.org/W1981010107","https://openalex.org/W1982258251","https://openalex.org/W1983379130","https://openalex.org/W1989658278","https://openalex.org/W1990038383","https://openalex.org/W1994190235","https://openalex.org/W1994724497","https://openalex.org/W2000323986","https://openalex.org/W2001712545","https://openalex.org/W2004611644","https://openalex.org/W2012568931","https://openalex.org/W2021818882","https://openalex.org/W2022720370","https://openalex.org/W2023945291","https://openalex.org/W2031563716","https://openalex.org/W2038491077","https://openalex.org/W2045316920","https://openalex.org/W2045413281","https://openalex.org/W2056102430","https://openalex.org/W2065188205","https://openalex.org/W2073990071","https://openalex.org/W2075035271","https://openalex.org/W2079877342","https://openalex.org/W2089532303","https://openalex.org/W2097259163","https://openalex.org/W2107842006","https://openalex.org/W2109327697","https://openalex.org/W2113012549","https://openalex.org/W2114445825","https://openalex.org/W2114829787","https://openalex.org/W2122339465","https://openalex.org/W2134053452","https://openalex.org/W2145889332","https://openalex.org/W2150419930","https://openalex.org/W2153586956","https://openalex.org/W2159156984","https://openalex.org/W2161908376","https://openalex.org/W2162873738","https://openalex.org/W2164714222","https://openalex.org/W2620241325","https://openalex.org/W7126786685"],"related_works":["https://openalex.org/W6958451663","https://openalex.org/W2532112957","https://openalex.org/W2001712545","https://openalex.org/W2004611644","https://openalex.org/W3204924349","https://openalex.org/W2021818882","https://openalex.org/W7131234081","https://openalex.org/W3160400036","https://openalex.org/W6939594837","https://openalex.org/W2767104316"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"characterized":[2],"by":[3,68,113,145],"dysregulated":[4],"systemic":[5],"inflammation":[6],"with":[7,54],"release":[8,131],"of":[9,72,88,111,165],"early":[10],"(for":[11,17],"example,":[12,18],"interleukin":[13],"(IL)-1\u03b2)":[14],"and":[15,84,124,129,141,148,167],"late":[16],"HMGB1)":[19,130],"proinflammatory":[20,126],"mediators":[21],"from":[22,138],"macrophages.":[23,60,133],"Plumbagin,":[24],"a":[25,77,153],"medicinal":[26],"plant-derived":[27],"naphthoquinone,":[28],"has":[29],"been":[30],"reported":[31],"to":[32],"exhibit":[33],"antiinflammatory":[34],"activity,":[35],"but":[36],"the":[37,49,55,70,82,89,93,158,163],"underling":[38],"mechanisms":[39],"remain":[40],"unclear.":[41],"Here,":[42],"we":[43],"have":[44],"demonstrated":[45],"that":[46],"plumbagin":[47,62,114,135],"inhibits":[48],"inflammatory":[50,168],"response":[51],"through":[52],"interfering":[53],"immunometabolism":[56,160],"pathway":[57,161],"in":[58,132,162],"activated":[59],"Remarkably,":[61],"inhibited":[63],"lipopolysaccharide":[64],"(LPS)-induced":[65],"aerobic":[66],"glycolysis":[67],"downregulating":[69],"expression":[71],"pyruvate":[73],"kinase":[74,79],"M2":[75],"(PKM2),":[76],"protein":[78],"responsible":[80],"for":[81,102,156],"final":[83],"rate-limiting":[85],"reaction":[86],"step":[87],"glycolytic":[90],"pathway.":[91],"Moreover,":[92],"NADPH":[94],"oxidase":[95],"4":[96],"(NOX4)-mediated":[97],"oxidative":[98],"stress":[99],"was":[100],"required":[101],"LPS-induced":[103,119],"PKM2":[104,120],"expression,":[105,121],"because":[106],"pharmacologic":[107],"or":[108,115],"genetic":[109],"inhibition":[110],"NOX4":[112],"RNA":[116],"interference":[117],"limited":[118],"lactate":[122],"production":[123],"subsequent":[125],"cytokine":[127],"(IL-1\u03b2":[128],"Finally,":[134],"protected":[136],"mice":[137],"lethal":[139],"endotoxemia":[140],"polymicrobial":[142],"sepsis":[143,166],"induced":[144],"cecal":[146],"ligation":[147],"puncture.":[149],"These":[150],"findings":[151],"identify":[152],"new":[154],"approach":[155],"inhibiting":[157],"NOX4/PKM2-dependent":[159],"treatment":[164],"diseases.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
