{"id":"https://openalex.org/W2299019138","doi":null,"title":"Transcriptional control in the murine adrenal cortex and testis","display_name":"Transcriptional control in the murine adrenal cortex and testis","publication_year":2016,"publication_date":"2016-04-15","ids":{"openalex":"https://openalex.org/W2299019138","mag":"2299019138"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/160814","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/160814","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/160814","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040996207","display_name":"Anja Schrade","orcid":"https://orcid.org/0000-0001-8634-4522","observed_orcids":["https://orcid.org/0000-0001-8634-4522"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anja Schrade","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8634-4522","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040996207"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.824999988079071},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8360000252723694},{"id":"https://openalex.org/keywords/adhesins","display_name":"adhesins","score":0.5559999942779541},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.49399998784065247},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.4320000112056732},{"id":"https://openalex.org/keywords/gonadal-differentiation","display_name":"gonadal differentiation","score":0.3310000002384186},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.7064138054847717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4590742290019989},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3771868646144867},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.354164719581604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3435206413269043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3431876003742218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26676449179649353}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/160814","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/160814","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2299019138","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/160814/3/Transcri.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/160814","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/160814","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":316,"referenced_works":["https://openalex.org/W37213203","https://openalex.org/W196443461","https://openalex.org/W199558621","https://openalex.org/W288155101","https://openalex.org/W629967745","https://openalex.org/W1481007760","https://openalex.org/W1486895198","https://openalex.org/W1488598317","https://openalex.org/W1498374309","https://openalex.org/W1511003303","https://openalex.org/W1524712950","https://openalex.org/W1526046639","https://openalex.org/W1528190409","https://openalex.org/W1534158259","https://openalex.org/W1537498059","https://openalex.org/W1537985401","https://openalex.org/W1539258085","https://openalex.org/W1541395198","https://openalex.org/W1546952499","https://openalex.org/W1557197255","https://openalex.org/W1561598641","https://openalex.org/W1567750872","https://openalex.org/W1577509897","https://openalex.org/W1600280267","https://openalex.org/W1602183952","https://openalex.org/W1660177314","https://openalex.org/W1750987510","https://openalex.org/W1765845624","https://openalex.org/W1768274470","https://openalex.org/W1860824570","https://openalex.org/W1926327739","https://openalex.org/W1931613387","https://openalex.org/W1963979543","https://openalex.org/W1967229730","https://openalex.org/W1967967974","https://openalex.org/W1967980238","https://openalex.org/W1968119300","https://openalex.org/W1968907717","https://openalex.org/W1968975770","https://openalex.org/W1970443640","https://openalex.org/W1970970038","https://openalex.org/W1973252220","https://openalex.org/W1973295687","https://openalex.org/W1973574401","https://openalex.org/W1976678205","https://openalex.org/W1976717257","https://openalex.org/W1976837011","https://openalex.org/W1978916626","https://openalex.org/W1979195490","https://openalex.org/W1979204710","https://openalex.org/W1979991129","https://openalex.org/W1980427996","https://openalex.org/W1981460612","https://openalex.org/W1982417024","https://openalex.org/W1982527680","https://openalex.org/W1983228128","https://openalex.org/W1984261567","https://openalex.org/W1984750674","https://openalex.org/W1985505412","https://openalex.org/W1985995555","https://openalex.org/W1987082843","https://openalex.org/W1987303855","https://openalex.org/W1987468247","https://openalex.org/W1987937341","https://openalex.org/W1988309701","https://openalex.org/W1990307219","https://openalex.org/W1990343493","https://openalex.org/W1991069718","https://openalex.org/W1991167271","https://openalex.org/W1991487604","https://openalex.org/W1991511577","https://openalex.org/W1991572217","https://openalex.org/W1991758223","https://openalex.org/W1994340375","https://openalex.org/W1994700466","https://openalex.org/W1994832543","https://openalex.org/W1995640088","https://openalex.org/W1996124528","https://openalex.org/W1998970590","https://openalex.org/W1999307950","https://openalex.org/W1999343359","https://openalex.org/W1999809584","https://openalex.org/W2002618476","https://openalex.org/W2003004843","https://openalex.org/W2004136915","https://openalex.org/W2004469122","https://openalex.org/W2006509394","https://openalex.org/W2007969716","https://openalex.org/W2008300544","https://openalex.org/W2008472259","https://openalex.org/W2009171847","https://openalex.org/W2010771180","https://openalex.org/W2011189608","https://openalex.org/W2011250757","https://openalex.org/W2011745438","https://openalex.org/W2011935366","https://openalex.org/W2013216633","https://openalex.org/W2013877353","https://openalex.org/W2014049460","https://openalex.org/W2015284522","https://openalex.org/W2015960141","https://openalex.org/W2016800963","https://openalex.org/W2017288138","https://openalex.org/W2017351518","https://openalex.org/W2017550401","https://openalex.org/W2018701607","https://openalex.org/W2019127826","https://openalex.org/W2020040835","https://openalex.org/W2020341451","https://openalex.org/W2021082765","https://openalex.org/W2021277262","https://openalex.org/W2021516648","https://openalex.org/W2022479321","https://openalex.org/W2022584463","https://openalex.org/W2023531352","https://openalex.org/W2023678272","https://openalex.org/W2025705782","https://openalex.org/W2026242783","https://openalex.org/W2026456961","https://openalex.org/W2029499458","https://openalex.org/W2029549744","https://openalex.org/W2029651564","https://openalex.org/W2029799875","https://openalex.org/W2029804435","https://openalex.org/W2031091378","https://openalex.org/W2033674005","https://openalex.org/W2033846465","https://openalex.org/W2034325295","https://openalex.org/W2035251881","https://openalex.org/W2035764924","https://openalex.org/W2035943019","https://openalex.org/W2036976320","https://openalex.org/W2037929083","https://openalex.org/W2039087309","https://openalex.org/W2039632791","https://openalex.org/W2040919102","https://openalex.org/W2041455809","https://openalex.org/W2042285454","https://openalex.org/W2042680929","https://openalex.org/W2043914264","https://openalex.org/W2044789020","https://openalex.org/W2045316197","https://openalex.org/W2046493120","https://openalex.org/W2049503985","https://openalex.org/W2049714108","https://openalex.org/W2050024457","https://openalex.org/W2050469657","https://openalex.org/W2050497323","https://openalex.org/W2051448662","https://openalex.org/W2053131896","https://openalex.org/W2053291546","https://openalex.org/W2053309035","https://openalex.org/W2053907558","https://openalex.org/W2055723072","https://openalex.org/W2057805027","https://openalex.org/W2059193912","https://openalex.org/W2059586182","https://openalex.org/W2059783931","https://openalex.org/W2060005335","https://openalex.org/W2061040489","https://openalex.org/W2062680616","https://openalex.org/W2063816440","https://openalex.org/W2064332932","https://openalex.org/W2064370516","https://openalex.org/W2064586774","https://openalex.org/W2064635904","https://openalex.org/W2065433877","https://openalex.org/W2069537490","https://openalex.org/W2070144391","https://openalex.org/W2070459825","https://openalex.org/W2071934356","https://openalex.org/W2072230422","https://openalex.org/W2072386144","https://openalex.org/W2072451938","https://openalex.org/W2072781709","https://openalex.org/W2073364104","https://openalex.org/W2073541423","https://openalex.org/W2074019299","https://openalex.org/W2074685588","https://openalex.org/W2075169962","https://openalex.org/W2075229853","https://openalex.org/W2076116049","https://openalex.org/W2077589781","https://openalex.org/W2077790055","https://openalex.org/W2078503449","https://openalex.org/W2078712321","https://openalex.org/W2078930878","https://openalex.org/W2079122334","https://openalex.org/W2079147888","https://openalex.org/W2079320255","https://openalex.org/W2080069132","https://openalex.org/W2082703776","https://openalex.org/W2083023185","https://openalex.org/W2083849493","https://openalex.org/W2084782500","https://openalex.org/W2085280452","https://openalex.org/W2088144323","https://openalex.org/W2089065850","https://openalex.org/W2089424961","https://openalex.org/W2089747862","https://openalex.org/W2092351713","https://openalex.org/W2092407833","https://openalex.org/W2092941848","https://openalex.org/W2095338629","https://openalex.org/W2095855014","https://openalex.org/W2097890006","https://openalex.org/W2098520903","https://openalex.org/W2099140108","https://openalex.org/W2099711527","https://openalex.org/W2100859941","https://openalex.org/W2101342713","https://openalex.org/W2102539516","https://openalex.org/W2103810926","https://openalex.org/W2103831817","https://openalex.org/W2105344558","https://openalex.org/W2105642898","https://openalex.org/W2106337624","https://openalex.org/W2107219745","https://openalex.org/W2107688352","https://openalex.org/W2108259939","https://openalex.org/W2108377754","https://openalex.org/W2108935114","https://openalex.org/W2109520380","https://openalex.org/W2110484500","https://openalex.org/W2110698122","https://openalex.org/W2110804359","https://openalex.org/W2110985070","https://openalex.org/W2112113834","https://openalex.org/W2112115346","https://openalex.org/W2112790709","https://openalex.org/W2114816848","https://openalex.org/W2115286474","https://openalex.org/W2116112998","https://openalex.org/W2116472345","https://openalex.org/W2116608195","https://openalex.org/W2117979987","https://openalex.org/W2118519085","https://openalex.org/W2119315422","https://openalex.org/W2119642891","https://openalex.org/W2120344271","https://openalex.org/W2120842955","https://openalex.org/W2122992197","https://openalex.org/W2123230988","https://openalex.org/W2125655418","https://openalex.org/W2127647846","https://openalex.org/W2128049766","https://openalex.org/W2128174750","https://openalex.org/W2128368447","https://openalex.org/W2129816618","https://openalex.org/W2130211930","https://openalex.org/W2131079238","https://openalex.org/W2131352876","https://openalex.org/W2131850468","https://openalex.org/W2132419180","https://openalex.org/W2135801344","https://openalex.org/W2136306240","https://openalex.org/W2138255346","https://openalex.org/W2138624097","https://openalex.org/W2140116116","https://openalex.org/W2140491078","https://openalex.org/W2140997010","https://openalex.org/W2142330433","https://openalex.org/W2142525239","https://openalex.org/W2143150139","https://openalex.org/W2143266180","https://openalex.org/W2143610955","https://openalex.org/W2143781769","https://openalex.org/W2145562458","https://openalex.org/W2146194848","https://openalex.org/W2148501348","https://openalex.org/W2150926065","https://openalex.org/W2152762661","https://openalex.org/W2153748424","https://openalex.org/W2153828013","https://openalex.org/W2154046204","https://openalex.org/W2154201149","https://openalex.org/W2155208844","https://openalex.org/W2155519853","https://openalex.org/W2156165856","https://openalex.org/W2156566088","https://openalex.org/W2157259126","https://openalex.org/W2157496815","https://openalex.org/W2157610967","https://openalex.org/W2158106539","https://openalex.org/W2158737623","https://openalex.org/W2158771177","https://openalex.org/W2159167521","https://openalex.org/W2159323290","https://openalex.org/W2160498764","https://openalex.org/W2161693710","https://openalex.org/W2162348930","https://openalex.org/W2162413723","https://openalex.org/W2163830368","https://openalex.org/W2164229548","https://openalex.org/W2164760878","https://openalex.org/W2164929923","https://openalex.org/W2164967582","https://openalex.org/W2165494231","https://openalex.org/W2166820565","https://openalex.org/W2167862718","https://openalex.org/W2169956655","https://openalex.org/W2170064419","https://openalex.org/W2170276453","https://openalex.org/W2170625377","https://openalex.org/W2171226274","https://openalex.org/W2172997339","https://openalex.org/W2185236260","https://openalex.org/W2188984405","https://openalex.org/W2252403865","https://openalex.org/W2273383057","https://openalex.org/W2277393269","https://openalex.org/W2280955573","https://openalex.org/W2311656734","https://openalex.org/W2334476405","https://openalex.org/W2395470083","https://openalex.org/W3150202998"],"related_works":["https://openalex.org/W2164198570","https://openalex.org/W1979204710","https://openalex.org/W2043914264","https://openalex.org/W7095792431","https://openalex.org/W1987468247","https://openalex.org/W1998970590","https://openalex.org/W2634929325","https://openalex.org/W46922868","https://openalex.org/W2094943403","https://openalex.org/W216139366"],"abstract_inverted_index":{"The":[0,80],"main":[1],"steroidogenic":[2,223],"organs":[3],"in":[4,31,71,111,131,159,167,186,207,228,240,249,258,288,312,330,338,353],"mammals,":[5],"the":[6,32,36,61,72,78,86,118,157,168,172,187,236,294,302,305,317,365,375],"adrenal":[7,73,189],"glands":[8],"and":[9,29,35,55,67,75,218,257,267,281,309,337,364],"gonads,":[10],"arise":[11],"from":[12],"a":[13,46,141,181,250,379],"common":[14],"pool":[15],"of":[16,39,48,77,82,88,98,126,144,171,221,238,286,304,320,350,358,377],"mesodermal":[17],"progenitor":[18],"cells":[19],"during":[20,175],"embryogenesis.":[21],"Precise":[22],"gene":[23,83,128,246,327,372],"regulation":[24],"controls":[25],"cell":[26,69,242,253,292,334],"differentiation,":[27],"growth,":[28],"homeostasis":[30],"developing":[33],"embryo":[34],"adult.":[37],"Disruptions":[38],"these":[40,106,321],"spatiotemporal":[41],"processes":[42],"are":[43],"linked":[44,136],"to":[45,91,105,117,137,155,300],"variety":[47],"diseases,":[49],"including":[50,265,356],"developmental":[51],"disorders,":[52],"malignant":[53],"transformations,":[54],"infertility.":[56],"This":[57],"dissertation":[58],"focuses":[59],"on":[60],"molecular":[62,318],"mechanisms":[63],"that":[64,114,271,384],"regulate":[65],"normal":[66],"neoplastic":[68],"development":[70],"cortex":[74],"testis":[76],"mouse.":[79,169],"initiation":[81],"transcription":[84,89,102,182],"requires":[85],"binding":[87,104],"factors":[90],"specific":[92],"cis-regulatory":[93],"elements":[94],"within":[95],"DNA.":[96],"Methylation":[97],"cytosine":[99],"residues":[100],"affects":[101],"factor":[103,183],"regulatory":[107],"elements;":[108],"hypermethylation":[109],"results":[110],"condensed":[112],"chromatin":[113],"is":[115,123,179,226,385],"inaccessible":[116],"transcriptional":[119],"machinery,":[120],"whereas":[121],"hypomethylation":[122],"an":[124,331],"indicator":[125],"active":[127],"transcription.":[129],"Alterations":[130],"DNA":[132],"methylation":[133,146,161],"have":[134],"been":[135,298],"neoplasia.":[138],"We":[139],"used":[140],"novel":[142],"method":[143],"genome-wide":[145],"profiling,":[147,269],"termed":[148],"Laser":[149],"Capture":[150],"Microdissection-Reduced":[151],"Representation":[152],"Bisulfite":[153],"Sequencing,":[154],"characterize":[156],"changes":[158],"promoter":[160],"associated":[162,213,275,346],"with":[163,201,214,276,347],"gonadectomy-induced":[164,176],"adrenocortical":[165,177],"neoplasia":[166,178],"One":[170],"genes":[173,351],"upregulated":[174],"Gata4,":[180],"normally":[184],"absent":[185],"adult":[188,313],"gland.":[190],"To":[191,232,315],"determine":[192],"whether":[193],"GATA4":[194,210,225,239,343],"directly":[195],"modulates":[196],"tumorigenesis":[197],"we":[198,244,324],"analyzed":[199],"mice":[200],"germline":[202],"or":[203],"conditional":[204],"loss-of-function":[205],"mutations":[206],"this":[208,241],"gene.":[209],"deficiency":[211],"was":[212,274,345],"reduced":[215],"tumor":[216,254],"growth":[217],"decreased":[219],"expression":[220,349],"sex":[222,278],"markers.":[224],"expressed":[227],"testicular":[229,290],"Leydig":[230,252,261],"cells.":[231,262,342],"gain":[233],"insight":[234],"into":[235],"role":[237],"type,":[243,293],"performed":[245,325],"silencing":[247,273,328,373],"experiments":[248,329],"mouse":[251,260,340],"line":[255,335],"(mLTC-1)":[256],"primary":[259,339],"Comprehensive":[263],"analyses,":[264],"transcriptomic":[266],"metabolomic":[268],"showed":[270],"Gata4":[272,287,326,371],"diminished":[277],"steroid":[279],"production":[280,376],"impaired":[282,374],"glycolysis.":[283],"Conditional":[284],"deletion":[285],"another":[289],"somatic":[291],"Sertoli":[295,333,341,381],"cell,":[296],"has":[297],"reported":[299],"increase":[301],"permeability":[303],"blood-testis":[306],"barrier":[307],"(BTB)":[308],"disrupt":[310],"spermatogenesis":[311],"mice.":[314],"elucidate":[316],"underpinnings":[319],"phenotypic":[322],"abnormalities,":[323],"immortalized":[332],"(TM4)":[336],"depletion":[344],"altered":[348],"involved":[352],"BTB":[354],"maintenance,":[355],"components":[357],"tight/adherens":[359],"junctions":[360],"(e.g.,":[361,368],"Tjp1,":[362],"Cldn12)":[363],"extracellular":[366],"matrix":[367],"Lamc1,":[369],"Col4a5).":[370],"lactate,":[378],"key":[380],"cell-derived":[382],"nutrient":[383],"essential":[386],"for":[387],"proper":[388],"spermatogenesis.":[389]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
