{"id":"https://openalex.org/W2298834916","doi":"https://doi.org/10.1016/j.orcp.2016.03.001","title":"CYP gene expressions in obesity-associated metabolic syndrome","display_name":"CYP gene expressions in obesity-associated metabolic syndrome","publication_year":2016,"publication_date":"2016-03-22","ids":{"openalex":"https://openalex.org/W2298834916","doi":"https://doi.org/10.1016/j.orcp.2016.03.001","mag":"2298834916","pmid":"https://pubmed.ncbi.nlm.nih.gov/27010496"},"language":"en","primary_location":{"id":"doi:10.1016/j.orcp.2016.03.001","doi":"https://doi.org/10.1016/j.orcp.2016.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orcp.2016.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S67314508","display_name":"Obesity Research & Clinical Practice","issn_l":"1871-403X","issn":["1871-403X","1878-0318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research & Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036455316","display_name":"Suzan Tabur","orcid":"https://orcid.org/0000-0002-5936-2888","observed_orcids":["https://orcid.org/0000-0002-5936-2888"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Suzan Tabur","raw_affiliation_strings":["Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: suzan2471@yahoo.com.tr","Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: suzan2471@yahoo.com.tr","institution_ids":["https://openalex.org/I59738393"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000034749","display_name":"Serdar \u00d6ztuzcu","orcid":"https://orcid.org/0000-0001-6871-6521","observed_orcids":["https://orcid.org/0000-0001-6871-6521","https://orcid.org/0000-0001-6014-969X"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serdar Oztuzcu","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019675478","display_name":"Eli\u0307f O\u011fuz","orcid":"https://orcid.org/0000-0002-8052-671X","observed_orcids":["https://orcid.org/0000-0002-8052-671X"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Oguz","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, Harran University, Sanliurfa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, Harran University, Sanliurfa, Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035549498","display_name":"\u015eeniz Demiry\u00fcrek","orcid":"https://orcid.org/0000-0003-4762-4745","observed_orcids":["https://orcid.org/0000-0003-4762-4745"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seniz Demiry\u00fcrek","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881036","display_name":"Hasan Da\u011fl\u0131","orcid":"https://orcid.org/0000-0003-2756-6277","observed_orcids":["https://orcid.org/0000-0003-2756-6277"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hasan Dagli","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035353182","display_name":"Belgin Ala\u015fehirli","orcid":"https://orcid.org/0000-0001-6072-2732","observed_orcids":["https://orcid.org/0000-0001-6072-2732"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Belgin Alasehirli","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039576612","display_name":"Mesut \u00d6zkaya","orcid":"https://orcid.org/0000-0003-2616-5885","observed_orcids":["https://orcid.org/0000-0003-2616-5885"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mesut Ozkaya","raw_affiliation_strings":["Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006568209","display_name":"Abdullah Tuncay Demiry\u00fcrek","orcid":"https://orcid.org/0000-0002-9994-8541","observed_orcids":["https://orcid.org/0000-0002-9994-8541"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdullah T. Demiry\u00fcrek","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036455316"],"corresponding_institution_ids":["https://openalex.org/I59738393"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.9818,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.70244095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"10","issue":"6","first_page":"719","last_page":"723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9010000228881836},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7919999957084656},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cyp2a6","display_name":"CYP2A6","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cyp4f2","display_name":"CYP4F2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp3a5","display_name":"CYP3A5","score":1.0},{"id":"https://openalex.org/keywords/cyp17a1","display_name":"CYP17A1","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.4309999942779541},{"id":"https://openalex.org/keywords/blood","display_name":"blood","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C142716871","wikidata":"https://www.wikidata.org/wiki/Q408305","display_name":"CYP17A1","level":3,"score":0.9169327616691589},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.778916597366333},{"id":"https://openalex.org/C92137452","wikidata":"https://www.wikidata.org/wiki/Q17912018","display_name":"CYP3A5","level":4,"score":0.7765463590621948},{"id":"https://openalex.org/C196013638","wikidata":"https://www.wikidata.org/wiki/Q14874295","display_name":"CYP2A6","level":5,"score":0.7676395177841187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5489268898963928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5388872623443604},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5314898490905762},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5175520777702332},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5172408223152161},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4748000204563141},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4347483515739441},{"id":"https://openalex.org/C203763787","wikidata":"https://www.wikidata.org/wiki/Q371029","display_name":"Null (SQL)","level":2,"score":0.43402644991874695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4319024085998535},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4011438190937042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36996060609817505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2757069766521454},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1506349742412567},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.1345801055431366},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09426039457321167},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072470","descriptor_name":"Cytochrome P450 Family 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072470","descriptor_name":"Cytochrome P450 Family 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065637","descriptor_name":"Cytochrome P-450 CYP2A6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065637","descriptor_name":"Cytochrome P-450 CYP2A6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.orcp.2016.03.001","doi":"https://doi.org/10.1016/j.orcp.2016.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orcp.2016.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S67314508","display_name":"Obesity Research & Clinical Practice","issn_l":"1871-403X","issn":["1871-403X","1878-0318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research & Clinical Practice","raw_type":"journal-article"},{"id":"pmid:27010496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27010496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity research & clinical practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1975248348","https://openalex.org/W1989552101","https://openalex.org/W1997754619","https://openalex.org/W2005387676","https://openalex.org/W2031918167","https://openalex.org/W2033697928","https://openalex.org/W2040085559","https://openalex.org/W2077861918","https://openalex.org/W2085646040","https://openalex.org/W2098196084","https://openalex.org/W2098695996","https://openalex.org/W2111329465","https://openalex.org/W2113238803","https://openalex.org/W2119290374","https://openalex.org/W2123289485","https://openalex.org/W2128099976","https://openalex.org/W2139118960","https://openalex.org/W2142672140","https://openalex.org/W2155076434","https://openalex.org/W2159714712","https://openalex.org/W2319299237","https://openalex.org/W2411114040","https://openalex.org/W4238251256","https://openalex.org/W4249825849","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2495924608","https://openalex.org/W4412043360","https://openalex.org/W2480394549","https://openalex.org/W7046878641","https://openalex.org/W2020608186","https://openalex.org/W7212325323","https://openalex.org/W2117192628","https://openalex.org/W7170137665","https://openalex.org/W1409532248","https://openalex.org/W1566042223"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}