{"id":"https://openalex.org/W2298830815","doi":null,"title":"Identifying the Surfaces of Human Protein TPP1 and Telomerase RNA that Interact with One Another to Improve Enzyme Function and Association at the Telomere","display_name":"Identifying the Surfaces of Human Protein TPP1 and Telomerase RNA that Interact with One Another to Improve Enzyme Function and Association at the Telomere","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2298830815","mag":"2298830815"},"language":"en","primary_location":{"id":"pmh:oai:cuscholar:0k225b48r","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/0k225b48r","pdf_url":"http://scholar.colorado.edu/downloads/xk81jk90h","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://scholar.colorado.edu/downloads/xk81jk90h","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063101043","display_name":"Caitlin Bell","orcid":"https://orcid.org/0000-0001-7352-142X","observed_orcids":["https://orcid.org/0000-0001-7352-142X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Caitlin Bell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063101043"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tpp1","display_name":"TPP1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/telomerase-rna","display_name":"telomerase RNA","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pot1","display_name":"POT1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/shelterin-complex","display_name":"shelterin complex","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ob-domain","display_name":"OB domain","score":0.6460000276565552},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8119999766349792},{"id":"https://openalex.org/keywords/telomeric-overhangs","display_name":"telomeric overhangs","score":0.6700000166893005},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.621999979019165},{"id":"https://openalex.org/keywords/dyskeratosis-congenita","display_name":"dyskeratosis congenita","score":0.8009999990463257},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9176442623138428},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8684329986572266},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6139348149299622},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5307673811912537},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5259390473365784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4964638352394104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4380350112915039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35321009159088135},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33581697940826416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24032875895500183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20971393585205078}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:cuscholar:0k225b48r","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/0k225b48r","pdf_url":"http://scholar.colorado.edu/downloads/xk81jk90h","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},{"id":"pmh:oai:scholar.colorado.edu:honr_theses-1444","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/honr_theses/249","pdf_url":"https://scholar.colorado.edu/honr_theses/249","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Honors Theses","raw_type":"text"},{"id":"mag:2298830815","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/honr_theses/249/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cuscholar:0k225b48r","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/0k225b48r","pdf_url":"http://scholar.colorado.edu/downloads/xk81jk90h","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2298830815.pdf","grobid_xml":"https://content.openalex.org/works/W2298830815.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1497143641","https://openalex.org/W1844827378","https://openalex.org/W1852455217","https://openalex.org/W1970801073","https://openalex.org/W1976494044","https://openalex.org/W1982199027","https://openalex.org/W1985910710","https://openalex.org/W1986659195","https://openalex.org/W1986808310","https://openalex.org/W1997141870","https://openalex.org/W1999334180","https://openalex.org/W2003446723","https://openalex.org/W2004561527","https://openalex.org/W2007663749","https://openalex.org/W2011882274","https://openalex.org/W2014414194","https://openalex.org/W2018618511","https://openalex.org/W2026856852","https://openalex.org/W2032407757","https://openalex.org/W2038661569","https://openalex.org/W2043740004","https://openalex.org/W2043764151","https://openalex.org/W2045702252","https://openalex.org/W2051990601","https://openalex.org/W2053620236","https://openalex.org/W2053875211","https://openalex.org/W2055707604","https://openalex.org/W2063914679","https://openalex.org/W2075714794","https://openalex.org/W2077449437","https://openalex.org/W2080032853","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2103393662","https://openalex.org/W2106996266","https://openalex.org/W2107665433","https://openalex.org/W2111458920","https://openalex.org/W2111772438","https://openalex.org/W2112888003","https://openalex.org/W2113168077","https://openalex.org/W2116212264","https://openalex.org/W2116282320","https://openalex.org/W2116490988","https://openalex.org/W2118999711","https://openalex.org/W2126564248","https://openalex.org/W2129992844","https://openalex.org/W2136206093","https://openalex.org/W2138398263","https://openalex.org/W2145952889","https://openalex.org/W2148197898","https://openalex.org/W2150490516","https://openalex.org/W2155983703","https://openalex.org/W2156857490","https://openalex.org/W2160850274","https://openalex.org/W2164449007","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2011882274","https://openalex.org/W2003446723","https://openalex.org/W2112110490","https://openalex.org/W1536545833","https://openalex.org/W2402779763","https://openalex.org/W2522514526","https://openalex.org/W2018887043","https://openalex.org/W4214776784","https://openalex.org/W2092226916","https://openalex.org/W4289032285"],"abstract_inverted_index":{"Telomerase":[0],"is":[1,153,168,210,231,244],"a":[2,19,46,85,102,128],"cellular":[3],"reverse":[4],"transcriptase":[5],"that":[6],"adds":[7],"tracts":[8],"of":[9,15,21,57,113,127,151,155,165,176,200,208,238,260],"telomeric":[10,41,75],"DNA":[11,34],"to":[12,52,71,89,99,179,204,220,241],"the":[13,23,39,53,58,62,72,106,111,114,162,169,173,180,185,213,227,236,242,257],"ends":[14],"linear":[16],"chromosomes":[17],"as":[18,144,253,255],"means":[20],"solving":[22],"end":[24,29],"replication":[25],"problem,":[26],"preventing":[27],"nonhomologous":[28],"joining,":[30],"and":[31,67,80,82,116,133,218,268],"eliminating":[32],"inappropriate":[33],"damage":[35],"response.":[36],"In":[37],"humans,":[38],"G-rich":[40],"repeats":[42],"are":[43,65],"bound":[44],"in":[45,61,101,118,172,226],"sequence-specific":[47],"manner":[48],"by":[49],"proteins":[50,59],"belonging":[51],"shelterin":[54,63],"complex.":[55],"Two":[56],"incorporated":[60],"complex":[64,86,95],"POT1":[66,69,88,152],"TPP1.":[68,234],"binds":[70],"single":[73],"stranded":[74],"overhang":[76],"with":[77,87,184,216,233],"high":[78],"affinity":[79],"specificity,":[81],"TPP1":[83,166],"forms":[84],"increase":[90],"POT1-DNA":[91],"affinity.":[92],"The":[93,148,198],"POT1-TPP1":[94],"has":[96],"been":[97],"found":[98],"participate":[100],"dual":[103],"role":[104],"at":[105],"chromosome":[107],"end,":[108],"both":[109],"protecting":[110],"integrity":[112],"telomere":[115,181,243],"engaging":[117],"telomerase":[119,178,186,228,239],"stimulation.":[120],"Oligonucleotide/oligosaccharide":[121],"binding":[122,142],"folds":[123],"(OB":[124],"domains)":[125],"consist":[126],"five-stranded":[129],"closed":[130],"beta":[131],"barrel,":[132],"most":[134],"OB-folds":[135],"use":[136],"this":[137,191,201],"folded":[138],"face":[139],"for":[140,212,246],"ligand":[141],"or":[143,196],"an":[145],"active":[146],"site.":[147],"DNA-binding":[149],"domain":[150,170],"composed":[154],"two":[156],"tandem":[157],"N-terminal":[158,163],"OB":[159],"domains.":[160],"Interestingly,":[161],"OB-fold":[164],"(TPP1-OB)":[167],"implicated":[171],"actual":[174],"act":[175],"recruiting":[177],"via":[182],"interaction":[183,192,215],"RNA":[187,229],"and/or":[188],"TERT":[189],"protein;":[190],"could":[193],"be":[194],"direct":[195],"indirect.":[197],"goal":[199],"work":[202],"was":[203],"elucidate":[205],"what":[206,222],"surface":[207],"TPP1-OB":[209],"responsible":[211],"recruitment":[214],"telomerase,":[217],"then":[219],"examine":[221],"element,":[223],"if":[224],"any,":[225],"subunit":[230],"interacting":[232],"Studying":[235],"mechanisms":[237],"access":[240],"essential":[245],"understanding":[247],"normal":[248],"biological":[249],"processes,":[250],"like":[251,262],"aging,":[252],"well":[254],"comprehending":[256],"mechanistic":[258],"cause":[259],"diseases":[261],"aplastic":[263],"anemia,":[264],"dyskeratosis":[265],"congenita,":[266],"cancer,":[267],"idiopathic":[269],"pulmonary":[270],"fibrosis.":[271]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
