{"id":"https://openalex.org/W2298732618","doi":"https://doi.org/10.1161/str.43.suppl_1.a2966","title":"Abstract 2966: Role of the Cerebral Vascular Toll-Like Receptor Signaling Pathway in Neuroprotection Induced by Combination Therapy of VELCADE and TPA","display_name":"Abstract 2966: Role of the Cerebral Vascular Toll-Like Receptor Signaling Pathway in Neuroprotection Induced by Combination Therapy of VELCADE and TPA","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2298732618","doi":"https://doi.org/10.1161/str.43.suppl_1.a2966","mag":"2298732618"},"language":"en","primary_location":{"id":"doi:10.1161/str.43.suppl_1.a2966","doi":"https://doi.org/10.1161/str.43.suppl_1.a2966","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.43.suppl_1.a2966","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Li Zhang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Li Zhang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032985983","display_name":"Zheng Gang Zhang","orcid":"https://orcid.org/0000-0002-9018-7723","observed_orcids":["https://orcid.org/0000-0002-9018-7723"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Gang Zhang","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Zheng Gang Zhang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Zheng Gang Zhang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059048948","display_name":"Hua Teng","orcid":"https://orcid.org/0000-0002-2982-1617","observed_orcids":["https://orcid.org/0000-0002-2982-1617"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Teng","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Hua Teng"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Hua Teng","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065975355","display_name":"Xianshuang Liu","orcid":"https://orcid.org/0000-0003-2414-321X","observed_orcids":["https://orcid.org/0000-0003-2414-321X","https://orcid.org/0000-0002-5561-4718"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianshuang Liu","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Xianshuang Liu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Xianshuang Liu","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005508444","display_name":"Michael Chopp","orcid":"https://orcid.org/0000-0002-1948-4493","observed_orcids":["https://orcid.org/0000-0002-1948-4493"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chopp","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Michael Chopp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Michael Chopp","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2803043754"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.906000018119812},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9380000233650208},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9210000038146973},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/irak1","display_name":"IRAK1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mir-146a","display_name":"miR-146a","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.6980000138282776},{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.6710000038146973},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8169999718666077},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9052633047103882},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.5613338947296143},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5506073832511902},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4684814214706421},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4637371301651001},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4406653046607971},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38138291239738464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32002949714660645},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.43.suppl_1.a2966","doi":"https://doi.org/10.1161/str.43.suppl_1.a2966","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.43.suppl_1.a2966","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164808955","https://openalex.org/W2755413029","https://openalex.org/W4237009950","https://openalex.org/W3109110441","https://openalex.org/W6884309155","https://openalex.org/W2622200243","https://openalex.org/W7142309710","https://openalex.org/W2990266451","https://openalex.org/W2004149652","https://openalex.org/W2755670555"],"abstract_inverted_index":{"Background":[0],"and":[1,6,46,73,101,194,212,232,256,294,298,324,334,357],"Purpose:":[2],"Toll-like":[3],"receptors":[4],"(TLRs)":[5],"their":[7],"family":[8],"members":[9],"including":[10,21],"IL-1":[11],"receptor-associated":[12],"kinase-1":[13],"(IRAK1)":[14],"mediate":[15],"ischemic":[16,159,233],"cell":[17,234],"damage.":[18,235],"MicroRNAs":[19],"(miRNAs)":[20],"miR-146a":[22,47,102,225,272,311,327],"regulate":[23],"TLRs.":[24],"The":[25],"present":[26],"study":[27],"investigated":[28],"whether":[29],"treatment":[30],"of":[31,44,58,99,122,126,204,243,252,266,287,303,351,355],"stroke":[32],"in":[33,38,48,103,135,145,158,181,210,214,218,284,305,339,347],"older":[34],"animals":[35],"with":[36,40,86,137,156,162,229,245,280],"VELCADE":[37,71,123,134,281,356],"combination":[39,136,171,223,353],"tPA":[41,74,87,138,163,174,358],"affects":[42],"expression":[43,125],"TLRs":[45,100,230,323],"cerebral":[49,67,104,111,147,340],"endothelial":[50,105,112,148,322,341],"cells.":[51],"Methods:":[52],"Wistar":[53],"rats":[54,84,160],"at":[55,247],"the":[56,119,146,170,285,335,348,352],"age":[57],"16-18":[59],"months":[60],"were":[61,76,93,107,115],"subjected":[62],"to":[63,202],"right":[64],"embolic":[65],"middle":[66],"artery":[68],"occlusion":[69],"(MCAo).":[70],"(0.1mg/kg)":[72],"(5mg/kg)":[75],"intravenously":[77],"administered":[78],"2h":[79],"after":[80],"MCAo":[81],"(n=16).":[82],"Ischemic":[83],"treated":[85,161,279],"alone":[88],"(n=14)":[89],"or":[90],"saline":[91],"(n=15)":[92],"used":[94,116],"as":[95],"control":[96],"groups.":[97],"Levels":[98],"cells":[106,113,149,342],"measured.":[108],"Cultured":[109],"primary":[110],"(PCECs)":[114],"for":[117,359],"investigating":[118],"direct":[120],"effect":[121,350],"on":[124],"miR-146a.":[127],"Results:":[128],"Quantitative":[129],"RT-PCR":[130,264],"analysis":[131,265],"revealed":[132],"that":[133,157,169,222,241,269,319,325,332],"significantly":[139],"increased":[140,250],"miR-l46a":[141],"levels":[142,231,251,273,291],"(11\u00b13":[143],"fold)":[144,255],"isolated":[150],"by":[151,274,292,313],"laser":[152],"capture":[153],"microdissection":[154],"compared":[155],"monotherapy":[164],"(2\u00b11).":[165],"Concurrently,":[166],"immunostaining":[167],"showed":[168,240,268],"therapy":[172,354],"suppressed":[173],"monotherapy-upregulated":[175],"TLR2":[176],"(44\u00b17":[177],"vs":[178,188,192,197,208],"93\u00b18/mm":[179],"2":[180],"tPA),":[182],"TLR4":[183],"(39\u00b16vs":[184],"91\u00b18),":[185],"IRAK1":[186,253,297,308],"(16\u00b13":[187],"46\u00b15),":[189],"fibrin":[190,246,270,288,320],"(17\u00b16":[191],"40\u00b13),":[193],"NF-kB":[195],"(9\u00b12":[196],"22\u00b13)":[198],"immunoreactive":[199],"vessels,":[200],"leading":[201],"reduction":[203],"infarct":[205],"volume":[206],"(14\u00b12":[207],"28\u00b13%":[209],"tPA,":[211],"30\u00b13%":[213],"saline,":[215],"p<0.05).":[216],"These":[217],"vivo":[219],"data":[220,317],"indicate":[221],"therapy-upregulated":[224],"is":[226],"inversely":[227],"related":[228],"In":[236],"vitro,":[237],"Western":[238],"blots":[239],"incubation":[242],"PCECs":[244,267,278,306],"1.5":[248],"\u00b5g/ml":[249],"(1.4":[254],"myeloid":[257],"differentiation":[258],"factor":[259],"88":[260],"(MyD88,":[261],"1.4":[262],"fold).":[263],"reduced":[271],"30":[275],"%.":[276],"However,":[277],"(10":[282],"ng/ml)":[283],"presence":[286],"elevated":[289],"miR-146":[290],"80%":[293],"abolished":[295],"fibrin-elevated":[296],"MyD88":[299],"proteins.":[300],"Moreover,":[301],"overexpression":[302],"miR146a":[304],"downregulated":[307],"protein,":[309],"a":[310],"target,":[312],"40%.":[314],"Conclusion:":[315],"Our":[316],"demonstrate":[318],"activates":[321],"VELCADE-upregulated":[326],"abolishes":[328],"tPA-induced":[329],"TLRs,":[330],"suggesting":[331],"miRNAs":[333],"TLR":[336],"signaling":[337],"pathway":[338],"play":[343],"an":[344],"important":[345],"role":[346],"neuroprotective":[349],"acute":[360],"stroke.":[361]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
