{"id":"https://openalex.org/W2298730034","doi":null,"title":"Regulation of the expression of HMG1, a co-activator of the estrogen receptor.","display_name":"Regulation of the expression of HMG1, a co-activator of the estrogen receptor.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2298730034","mag":"2298730034","pmid":"https://pubmed.ncbi.nlm.nih.gov/11299752"},"language":"en","primary_location":{"id":"pmid:11299752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11299752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025601685","display_name":"Lars Borrmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180437899","display_name":"University of Bremen","ror":"https://ror.org/04ers2y35","country_code":"DE","type":"education","lineage":["https://openalex.org/I180437899"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Borrmann","raw_affiliation_strings":["Center for Human Genetics, University of Bremen, Leobenerstr, ZHG, D-28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, University of Bremen, Leobenerstr, ZHG, D-28359 Bremen, Germany","institution_ids":["https://openalex.org/I180437899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034257386","display_name":"Inae Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061941811","display_name":"Daniel Schultheiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Schultheiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111960791","display_name":"Piere Rogalla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Rogalla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111778364","display_name":"J\u00f6rn Bullerdiek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Bullerdiek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8671,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.64569011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"1A","first_page":"301","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmg1","display_name":"HMG1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7170000076293945},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.8090000152587891},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.953000009059906},{"id":"https://openalex.org/keywords/cisplatin-sensitivity","display_name":"cisplatin sensitivity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.781000018119812},{"id":"https://openalex.org/keywords/intron-1","display_name":"intron 1","score":0.6100000143051147},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6650575399398804},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6366004347801208},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5475016236305237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199093222618103},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4600626528263092},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.43586423993110657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3698752522468567},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3566249907016754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.351712167263031},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2300243377685547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2112341821193695},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17740899324417114},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07933101058006287}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11299752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11299752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2298730034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11299752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080360198","https://openalex.org/W2088445980","https://openalex.org/W4248976313","https://openalex.org/W2916886280","https://openalex.org/W2033226021","https://openalex.org/W7099209864","https://openalex.org/W2157078215","https://openalex.org/W1991297181","https://openalex.org/W1966591852","https://openalex.org/W2159416234"],"abstract_inverted_index":{"HMG1":[0,36,58,73,90,142],"is":[1,24,37,133],"a":[2,26,99,110,138,153,157],"protein":[3],"of":[4,10,28,31,55,57,71,89,125,141,149,160],"high":[5],"clinical":[6],"significance.":[7],"Besides":[8],"shielding":[9],"DNA":[11],"adducts":[12],"against":[13],"repair":[14],"enzymes":[15],"making":[16,146],"cells":[17],"more":[18],"sensitive":[19],"to":[20],"cisplatin":[21,170],"therapy,":[22],"it":[23],"also":[25],"co-modulator":[27],"the":[29,53,68,87,95,123,147,167],"activity":[30],"steroid":[32,43],"hormone-regulated":[33],"genes.":[34],"Although":[35],"regulated":[38],"by":[39,79,94,144],"various":[40],"factors,":[41],"including":[42,59],"hormone":[44],"estrogen,":[45],"nothing":[46],"was":[47],"known":[48],"about":[49],"regulatory":[50,77,106],"sequences.":[51],"Also":[52],"sequence":[54],"parts":[56],"its":[60,76],"promoter":[61,83,96],"remains":[62],"still":[63],"unknown.":[64],"We":[65],"have":[66],"completed":[67],"genomic":[69],"organization":[70],"human":[72],"and":[74,104,116,166],"characterized":[75],"region":[78],"luciferase":[80],"assay":[81],"for":[82,156],"activity.":[84],"Insights":[85],"into":[86],"regulation":[88],"expression":[91],"are":[92],"given":[93],"analysis":[97],"showing":[98],"strong":[100],"functional":[101],"promoter,":[102],"enhancing":[103],"negative":[105],"regions":[107],"together":[108],"with":[109,164],"CpG":[111],"island":[112],"in":[113],"intron":[114,131],"1":[115,132],"several":[117],"transcription":[118],"factor":[119],"binding":[120],"sites.":[121],"Furthermore,":[122],"finding":[124],"two":[126],"estrogen":[127,145,151,165],"responsive":[128],"elements":[129],"within":[130],"relevant":[134],"as":[135],"they":[136],"indicate":[137],"direct":[139],"mechanism":[140],"up-regulation":[143],"presence":[148],"an":[150],"receptor":[152],"significant":[154],"marker":[155],"combined":[158],"treatment":[159],"special":[161],"tumor":[162],"types":[163],"anticancer":[168],"drugs":[169],"or":[171],"carboplatin.":[172]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}