{"id":"https://openalex.org/W22986190","doi":null,"title":"Hepatocellular cytokeratins as substrates of transglutaminases.","display_name":"Hepatocellular cytokeratins as substrates of transglutaminases.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W22986190","mag":"22986190","pmid":"https://pubmed.ncbi.nlm.nih.gov/2481149"},"language":"en","primary_location":{"id":"pmid:2481149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2481149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032058761","display_name":"Kurt Zatloukal","orcid":"https://orcid.org/0000-0001-5299-7218","observed_orcids":["https://orcid.org/0000-0001-5299-7218"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K Zatloukal","raw_affiliation_strings":["Division of Molecular Pathology, University of Graz School of Medicine, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, University of Graz School of Medicine, Austria","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072719639","display_name":"Helmut Denk","orcid":"https://orcid.org/0000-0001-6959-0828","observed_orcids":["https://orcid.org/0000-0001-6959-0828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Denk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403562","display_name":"Elisabeth Lackinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Lackinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108459128","display_name":"Ingrid Rainer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Rainer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8113,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.66649564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"6","first_page":"603","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transglutaminase","display_name":"transglutaminase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/protein-cross-linking","display_name":"protein cross-linking","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.6499999761581421},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5220000147819519},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8880000114440918},{"id":"https://openalex.org/keywords/guinea-pig-liver","display_name":"guinea pig liver","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mouse-liver","display_name":"mouse liver","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.8945883512496948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5461486577987671},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5377400517463684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5185626149177551},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4914590120315552},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4815019369125366},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.46968987584114075},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.4505114257335663},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.4448598623275757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3256152272224426},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30635517835617065},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18734094500541687},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10607418417930603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08505040407180786},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2481149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2481149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:22986190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2481149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W184973133","https://openalex.org/W1564219524","https://openalex.org/W1575368646","https://openalex.org/W1963762925","https://openalex.org/W1964717752","https://openalex.org/W1972795257","https://openalex.org/W1977359306","https://openalex.org/W1978263195","https://openalex.org/W1979781775","https://openalex.org/W1993114146","https://openalex.org/W1998385652","https://openalex.org/W2003343094","https://openalex.org/W2003468371","https://openalex.org/W2007632863","https://openalex.org/W2041110655","https://openalex.org/W2046139052","https://openalex.org/W2050026551","https://openalex.org/W2058160797","https://openalex.org/W2087350807","https://openalex.org/W2089244161","https://openalex.org/W2090942324","https://openalex.org/W2095896181","https://openalex.org/W2096858216","https://openalex.org/W2102278984","https://openalex.org/W2109733963","https://openalex.org/W2112758751","https://openalex.org/W2117699910","https://openalex.org/W2142456288","https://openalex.org/W2153919085","https://openalex.org/W2158377738","https://openalex.org/W2161933451","https://openalex.org/W2162267998","https://openalex.org/W2163608282","https://openalex.org/W2170036982","https://openalex.org/W2410104153","https://openalex.org/W4229893564"],"related_works":["https://openalex.org/W1966405730","https://openalex.org/W2069044158","https://openalex.org/W2461903263","https://openalex.org/W2603463796","https://openalex.org/W4415090841","https://openalex.org/W1997482541","https://openalex.org/W2009577271","https://openalex.org/W3005817595","https://openalex.org/W2071306432","https://openalex.org/W4251394387"],"abstract_inverted_index":{"To":[0],"examine":[1],"whether":[2],"hepatocellular":[3],"cytokeratins":[4,22,85,94,112],"can":[5,113],"serve":[6,114],"as":[7,17,19,42,52,54,69,93,115,150],"substrates":[8,116,146],"of":[9,14,117,147,168,192,195],"transglutaminases":[10],"(TG)":[11],"TG-catalyzed":[12],"incorporation":[13],"[3H]putrescine":[15],"into,":[16],"well":[18,53],"cross-linking":[20,149,194],"of,":[21],"was":[23,86],"studied.":[24],"Purified":[25],"guinea":[26],"pig":[27],"liver":[28,32,46,62,82,111,123,204],"TG":[29,33],"and":[30,60,66,119,127],"mouse":[31,45,81,110],"present":[34],"in":[35,130,198],"105,000":[36],"x":[37],"g":[38],"supernatants":[39],"were":[40,91,144],"used":[41],"enzymes.":[43],"Isolated":[44],"cytokeratin":[47,55,63,104,124,179],"filaments,":[48],"heterotypic":[49],"tetramers":[50],"(A2D2),":[51],"filaments":[56],"reconstituted":[57],"from":[58],"isolated":[59],"column-purified":[61],"polypeptides":[64,180],"A":[65,126,143],"D":[67,128,140],"served":[68],"substrates.":[70],"Moreover,":[71],"to":[72,160],"more":[73,174],"closely":[74],"mimic":[75],"the":[76,79,135,162,169,182,188],"situation":[77],"within":[78,181],"cell,":[80],"homogenate":[83],"containing":[84],"also":[87],"used.":[88],"Cross-linked":[89],"proteins":[90],"identified":[92],"by":[95,152],"immunoblotting":[96],"after":[97],"sodium":[98],"dodecyl":[99],"sulfate-polyacrylamide":[100],"gel":[101],"electrophoresis":[102],"using":[103],"antibodies.":[105],"The":[106,184],"results":[107,185],"indicated":[108],"that":[109,200],"homologous":[118,178],"heterologous":[120],"TG.":[121],"However,":[122],"components":[125,139,142,197],"differed":[129],"this":[131],"respect.":[132],"Depending":[133],"on":[134],"experimental":[136],"conditions":[137],"either":[138],"or":[141],"better":[145],"TG-mediated":[148],"revealed":[151],"increased":[153,209],"high":[154],"molecular":[155],"weight":[156],"aggregates,":[157],"which":[158],"failed":[159],"enter":[161],"gels,":[163],"concomitant":[164],"with":[165,208],"a":[166,173],"decrease":[167],"monomer":[170],"band":[171],"suggesting":[172],"intimate":[175],"relationship":[176],"between":[177],"filament.":[183],"presented":[186],"provide":[187],"basis":[189],"for":[190],"studies":[191],"TG-induced":[193],"cytoskeletal":[196],"hepatocytes":[199],"may":[201],"occur":[202],"during":[203],"cell":[205],"injury":[206],"associated":[207],"intracellular":[210],"Ca2+":[211],"concentrations.":[212]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
