{"id":"https://openalex.org/W2298338339","doi":"https://doi.org/10.4049/jimmunol.1500908","title":"Glial Cell\u2013Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome\u2013Dependent IL-1\u03b2 Production","display_name":"Glial Cell\u2013Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome\u2013Dependent IL-1\u03b2 Production","publication_year":2016,"publication_date":"2016-03-17","ids":{"openalex":"https://openalex.org/W2298338339","doi":"https://doi.org/10.4049/jimmunol.1500908","mag":"2298338339","pmid":"https://pubmed.ncbi.nlm.nih.gov/26983788"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1500908","doi":"https://doi.org/10.4049/jimmunol.1500908","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1500908","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/9/3794.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jimmunol.org/content/jimmunol/196/9/3794.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002257874","display_name":"Mar\u00eda Cruz Miraglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M Cruz Miraglia","raw_affiliation_strings":["Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053335050","display_name":"Miriam M. Costa Franco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Miriam M Costa Franco","raw_affiliation_strings":["Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629890","display_name":"Ana M. Rodr\u00edguez","orcid":"https://orcid.org/0009-0000-4629-0910","observed_orcids":["https://orcid.org/0009-0000-4629-0910"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ana M Rodriguez","raw_affiliation_strings":["Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006085630","display_name":"Paula Maria Quaglio Bellozi","orcid":"https://orcid.org/0000-0001-6976-9633","observed_orcids":["https://orcid.org/0000-0001-6976-9633"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paula M Q Bellozi","raw_affiliation_strings":["Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6976-9633","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112055554","display_name":"Carina Cintia Ferrari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Carina C Ferrari","raw_affiliation_strings":["Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]},{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102300761","display_name":"Mar\u00eda Isabel Far\u00edas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria I Farias","raw_affiliation_strings":["Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]},{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063851790","display_name":"Vida A. Dennis","orcid":"https://orcid.org/0000-0003-1409-5605","observed_orcids":["https://orcid.org/0000-0003-1409-5605"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vida A Dennis","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University , Montgomery, AL 36104"],"raw_orcid":"https://orcid.org/0000-0003-1409-5605","affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University , Montgomery, AL 36104","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065910864","display_name":"Paula Barrionuevo","orcid":"https://orcid.org/0000-0002-4940-4263","observed_orcids":["https://orcid.org/0000-0002-4940-4263"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Paula Barrionuevo","raw_affiliation_strings":["Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073191722","display_name":"Ant\u00f4nio Carlos Pinheiro de Oliveira","orcid":"https://orcid.org/0000-0003-3217-4294","observed_orcids":["https://orcid.org/0000-0003-3217-4294"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio C P de Oliveira","raw_affiliation_strings":["Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088657339","display_name":"Fernando Juan Pitossi","orcid":"https://orcid.org/0000-0001-5104-9726","observed_orcids":["https://orcid.org/0000-0001-5104-9726"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Fernando Pitossi","raw_affiliation_strings":["Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council , Buenos Aires C1405BWE ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]},{"raw_affiliation_string":"Leloir Institute Foundation, Biochemical Research Institute of Buenos Aires/National Scientific and Technical Research Council, Buenos Aires C1405BWE, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016165244","display_name":"Kwang Sik Kim","orcid":"https://orcid.org/0000-0002-3939-8568","observed_orcids":["https://orcid.org/0000-0002-3939-8568"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwang Sik Kim","raw_affiliation_strings":["Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD 21287"],"raw_orcid":"https://orcid.org/0000-0002-3939-8568","affiliations":[{"raw_affiliation_string":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD 21287","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018272765","display_name":"M. Victoria Delpino","orcid":"https://orcid.org/0000-0003-2077-8509","observed_orcids":["https://orcid.org/0000-0003-2077-8509"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M Victoria Delpino","raw_affiliation_strings":["Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078687523","display_name":"Sergio Costa Oliveira","orcid":"https://orcid.org/0000-0003-4062-5577","observed_orcids":["https://orcid.org/0000-0003-4062-5577"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sergio Costa Oliveira","raw_affiliation_strings":["Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte-Minas Gerais 31270-901 ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088093222","display_name":"Guillermo H. Giambartolomei","orcid":"https://orcid.org/0000-0001-7441-5311","observed_orcids":["https://orcid.org/0000-0001-7441-5311"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Guillermo H Giambartolomei","raw_affiliation_strings":["Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Genetics and Metabolism (National Scientific and Technical Research Council/University of Buenos Aires), Clinical Hospital Jos\u00e9 de San Mart\u00edn, Faculty of Medicine, University of Buenos Aires , Buenos Aires C1120AAR ,","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5065910864"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210119967"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.7223,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.83704723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"196","issue":"9","first_page":"3794","last_page":"3805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.21040000021457672,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurobrucellosis","display_name":"neurobrucellosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/brucella-abortus","display_name":"Brucella abortus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.953000009059906},{"id":"https://openalex.org/keywords/aim2","display_name":"AIM2","score":0.5299999713897705},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/monocyte-migration","display_name":"monocyte migration","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2778579951","wikidata":"https://www.wikidata.org/wiki/Q11353905","display_name":"Brucella abortus","level":3,"score":0.804067850112915},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.8014533519744873},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5505408048629761},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46609818935394287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4046165943145752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3555423617362976},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3333067297935486},{"id":"https://openalex.org/C2781429187","wikidata":"https://www.wikidata.org/wiki/Q156050","display_name":"Brucellosis","level":2,"score":0.26288357377052307},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21018564701080322}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002003","descriptor_name":"Brucella abortus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002006","descriptor_name":"Brucellosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053468","descriptor_name":"CARD Signaling Adaptor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1500908","doi":"https://doi.org/10.4049/jimmunol.1500908","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1500908","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/9/3794.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:26983788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26983788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/23627","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/23627","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/89491","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/89491","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.1500908","doi":"https://doi.org/10.4049/jimmunol.1500908","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1500908","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/9/3794.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1481957606","display_name":null,"funder_award_id":"20020120100128","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G1590982832","display_name":null,"funder_award_id":"2013\u201001","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G1803139745","display_name":null,"funder_award_id":"030448/2013-01","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G3150525304","display_name":null,"funder_award_id":"20020090200012","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G3154116105","display_name":null,"funder_award_id":"2014\u20102","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G354268126","display_name":"Center for NanoBiotechnology Research","funder_award_id":"1241701","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4633323896","display_name":null,"funder_award_id":"464711/2014-2","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6258607612","display_name":null,"funder_award_id":"UBACYT 20020090200012","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G640620333","display_name":null,"funder_award_id":"443662/2014-2","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6437830805","display_name":null,"funder_award_id":"20020120100128","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G6531919598","display_name":null,"funder_award_id":"PICT 2012","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G841842749","display_name":null,"funder_award_id":"2011-","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320323809","display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o","ror":"https://ror.org/04d0xx942"},{"id":"https://openalex.org/F4320335478","display_name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2298338339.pdf","grobid_xml":"https://content.openalex.org/works/W2298338339.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W126845423","https://openalex.org/W251547543","https://openalex.org/W1522048223","https://openalex.org/W1625397436","https://openalex.org/W1866384779","https://openalex.org/W1928287863","https://openalex.org/W1952514571","https://openalex.org/W1957113176","https://openalex.org/W1964977785","https://openalex.org/W1967269498","https://openalex.org/W1971813534","https://openalex.org/W1973628272","https://openalex.org/W1981522844","https://openalex.org/W1984399406","https://openalex.org/W1990295868","https://openalex.org/W1998172717","https://openalex.org/W2006919110","https://openalex.org/W2006990207","https://openalex.org/W2007579227","https://openalex.org/W2009934440","https://openalex.org/W2013216100","https://openalex.org/W2024307950","https://openalex.org/W2024885545","https://openalex.org/W2046484793","https://openalex.org/W2051947267","https://openalex.org/W2053963421","https://openalex.org/W2065118690","https://openalex.org/W2069902118","https://openalex.org/W2070207411","https://openalex.org/W2070597700","https://openalex.org/W2074477317","https://openalex.org/W2079320514","https://openalex.org/W2086050354","https://openalex.org/W2088466545","https://openalex.org/W2090697934","https://openalex.org/W2091559311","https://openalex.org/W2101248896","https://openalex.org/W2104195963","https://openalex.org/W2113981042","https://openalex.org/W2118309500","https://openalex.org/W2120049814","https://openalex.org/W2121470421","https://openalex.org/W2123811305","https://openalex.org/W2126036578","https://openalex.org/W2128968036","https://openalex.org/W2139536247","https://openalex.org/W2145938600","https://openalex.org/W2146582952","https://openalex.org/W2146811846","https://openalex.org/W2147283307","https://openalex.org/W2150702412","https://openalex.org/W2152423594","https://openalex.org/W2155075033","https://openalex.org/W2158966093","https://openalex.org/W2167007850","https://openalex.org/W2184291182","https://openalex.org/W2333450271","https://openalex.org/W2425328771","https://openalex.org/W2777548161","https://openalex.org/W2789870354","https://openalex.org/W4249530148","https://openalex.org/W4250078597","https://openalex.org/W4255253515","https://openalex.org/W6605178599"],"related_works":["https://openalex.org/W2465319903","https://openalex.org/W4391144433","https://openalex.org/W3080092311","https://openalex.org/W2006919110","https://openalex.org/W2113981042","https://openalex.org/W2606385352","https://openalex.org/W7019799125","https://openalex.org/W7125428496","https://openalex.org/W2167007850","https://openalex.org/W2945029186"],"abstract_inverted_index":{"Blood-brain":[0],"barrier":[1,269],"activation":[2,30,86,103,161,177,265],"and/or":[3],"dysfunction":[4],"are":[5,17,156],"a":[6,67,91,126,152,238],"common":[7],"feature":[8],"of":[9,31,46,54,62,69,87,104,135,178,217,226,234,253,266],"human":[10,32],"neurobrucellosis,":[11],"but":[12,89],"the":[13,52,60,179,215,220,232,254,264,267],"underlying":[14],"pathogenic":[15],"mechanisms":[16],"largely":[18],"unknown.":[19],"In":[20],"this":[21,275],"article,":[22],"we":[23],"describe":[24],"an":[25,211],"immune":[26],"mechanism":[27],"for":[28,159],"inflammatory":[29],"brain":[33,180,221],"microvascular":[34],"endothelial":[35],"cells":[36,76,98,187,209],"(HBMEC)":[37],"in":[38,119,145,185,210,231,244,257,270],"response":[39],"to":[40,90,129,175,263],"infection":[41],"with":[42,48,66,81,137],"Brucella":[43],"abortus":[44,50,83,228,261],"Infection":[45],"HBMEC":[47,105,131,141,200],"B.":[49,82,95,113,227,260],"induced":[51,85],"secretion":[53,184],"IL-6,":[55],"IL-8,":[56],"and":[57,59,78,101,116,121,148,162,191,196,214,242,272],"MCP-1,":[58],"upregulation":[61],"CD54":[63],"(ICAM-1),":[64],"consistent":[65],"state":[68],"activation.":[70,132,142],"Culture":[71],"supernatants":[72],"(CS)":[73],"from":[74,112,206],"glial":[75,97,186,208],"(astrocytes":[77],"microglia)":[79],"infected":[80],"also":[84],"HBMEC,":[88],"greater":[92],"extent.":[93],"Although":[94],"abortus-infected":[96,114],"secreted":[99],"IL-1\u03b2":[100,109,163,183,273],"TNF-\u03b1,":[102],"was":[106,202,229],"dependent":[107],"on":[108,189],"because":[110],"CS":[111,136,205],"astrocytes":[115],"microglia":[117],"deficient":[118],"caspase-1":[120,160],"apoptosis-associated":[122,168],"speck-like":[123,169],"protein":[124,170],"containing":[125,151,171,237],"CARD":[127],"failed":[128],"induce":[130],"Consistently,":[133],"treatment":[134],"neutralizing":[138],"anti-IL-1\u03b2":[139],"inhibited":[140],"Both":[143],"absent":[144,243],"melanoma":[146,245],"2":[147],"Nod-like":[149,235],"receptor":[150,236],"pyrin":[153,239],"domain":[154,240],"3":[155,241],"partially":[157],"required":[158],"secretion,":[164],"suggesting":[165],"that":[166,250],"multiple":[167],"CARD-dependent":[172],"inflammasomes":[173],"contribute":[174],"IL-1\u03b2-induced":[176],"microvasculature.":[181],"Inflammasome-mediated":[182],"depends":[188],"TLR2":[190],"MyD88":[192],"adapter-like/TIRAP.":[193],"Finally,":[194],"neutrophil":[195],"monocyte":[197],"migration":[198],"across":[199],"monolayers":[201],"increased":[203],"by":[204,259],"Brucella-infected":[207],"IL-1\u03b2-dependent":[212],"fashion,":[213],"infiltration":[216],"neutrophils":[218],"into":[219],"parenchyma":[222],"upon":[223],"intracranial":[224],"injection":[225],"diminished":[230],"absence":[233],"2.":[246],"Our":[247],"results":[248],"indicate":[249],"innate":[251],"immunity":[252],"CNS":[255],"set":[256],"motion":[258],"contributes":[262],"blood-brain":[268],"neurobrucellosis":[271],"mediates":[274],"phenomenon.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}