{"id":"https://openalex.org/W2298296233","doi":"https://doi.org/10.1016/j.jpba.2016.03.036","title":"Determination of ulixertinib in mice plasma by LC\u2013MS/MS and its application to a pharmacokinetic study in mice","display_name":"Determination of ulixertinib in mice plasma by LC\u2013MS/MS and its application to a pharmacokinetic study in mice","publication_year":2016,"publication_date":"2016-03-17","ids":{"openalex":"https://openalex.org/W2298296233","doi":"https://doi.org/10.1016/j.jpba.2016.03.036","mag":"2298296233","pmid":"https://pubmed.ncbi.nlm.nih.gov/27017572"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpba.2016.03.036","doi":"https://doi.org/10.1016/j.jpba.2016.03.036","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2016.03.036","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087185152","display_name":"Rajinish Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajinish Kumar","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055891502","display_name":"Suresh Ponnayyan Sulochana","orcid":"https://orcid.org/0000-0003-0665-9757","observed_orcids":["https://orcid.org/0000-0003-0665-9757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.S. Suresh","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051572266","display_name":"G Rudresh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Rudresh","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111184517","display_name":"Mohd Zainuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohd Zainuddin","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082153367","display_name":"Purushottam M. Dewang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Purushottam Dewang","raw_affiliation_strings":["Medicinal Chemistry, Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021908899","display_name":"Raghava Reddy Kethiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ragahava Reddy Kethiri","raw_affiliation_strings":["Medicinal Chemistry, Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110299004","display_name":"Sriram Rajagopal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sriram Rajagopal","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083166265","display_name":"Ramesh Mullangi","orcid":"https://orcid.org/0000-0003-1359-8999","observed_orcids":["https://orcid.org/0000-0003-1359-8999"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramesh Mullangi","raw_affiliation_strings":["Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India. Electronic address: mullangi_ramesh@jubilantinnovation.com","Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India. Electronic address: mullangi_ramesh@jubilantinnovation.com","institution_ids":[]},{"raw_affiliation_string":"Jubilant Biosys Ltd., Industrial Suburb, Yeshwanthpur, Bangalore 560 022, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083166265"],"corresponding_institution_ids":[],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":1.2772,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74305529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"125","issue":null,"first_page":"140","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulixertinib","display_name":"ulixertinib","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plasma-drug-quantitation","display_name":"plasma drug quantification","score":0.8050000071525574},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/phenacetin-internal-standard","display_name":"phenacetin internal standard","score":0.9589999914169312},{"id":"https://openalex.org/keywords/protein-precipitation","display_name":"protein precipitation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5210000276565552},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9553279876708984},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8933389186859131},{"id":"https://openalex.org/C74774607","wikidata":"https://www.wikidata.org/wiki/Q7251495","display_name":"Protein precipitation","level":3,"score":0.8395323753356934},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.795205295085907},{"id":"https://openalex.org/C2775922563","wikidata":"https://www.wikidata.org/wiki/Q419175","display_name":"Phenacetin","level":2,"score":0.7716776728630066},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6495577692985535},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.648931622505188},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.5073418021202087},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.4354642331600189},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.32914382219314575},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.32751792669296265},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0726814866065979},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpba.2016.03.036","doi":"https://doi.org/10.1016/j.jpba.2016.03.036","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2016.03.036","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},{"id":"pmid:27017572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27017572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical and biomedical analysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2016968987","https://openalex.org/W2216253840","https://openalex.org/W2241986021","https://openalex.org/W2595398870"],"related_works":["https://openalex.org/W2241599364","https://openalex.org/W3002160164","https://openalex.org/W2486944448","https://openalex.org/W2903728382","https://openalex.org/W2094858757","https://openalex.org/W2612241047","https://openalex.org/W4294719127","https://openalex.org/W2767964063","https://openalex.org/W2359580704","https://openalex.org/W2759388442"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}