{"id":"https://openalex.org/W2298255197","doi":null,"title":"Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor.","display_name":"Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor.","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2298255197","mag":"2298255197","pmid":"https://pubmed.ncbi.nlm.nih.gov/24844175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4117389"},"language":"en","primary_location":{"id":"pmid:24844175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24844175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgical sciences","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4117389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040059449","display_name":"Ike dela Pe\u00f1a","orcid":"https://orcid.org/0000-0003-2046-522X","observed_orcids":["https://orcid.org/0000-0003-2046-522X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Dela Pe\u00f1a","raw_affiliation_strings":["Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain Repair University of South Florida Morsani College of Medicine Tampa, FL, USA - cborlong@health.usf.edu","University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain Repair University of South Florida Morsani College of Medicine Tampa, FL, USA - cborlong@health.usf.edu","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076374058","display_name":"Paul R. Sanberg","orcid":"https://orcid.org/0000-0001-9130-4592","observed_orcids":["https://orcid.org/0000-0001-9130-4592"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P R Sanberg","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109966225","display_name":"Sandra Acosta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Acosta","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042051550","display_name":"Naoki Tajiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Tajiri","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106977093","display_name":"Shinn-Zong Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Z Lin","raw_affiliation_strings":["Center for Neuropsychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropsychiatry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035194870","display_name":"Cesar V. Borlongan","orcid":"https://orcid.org/0000-0002-2966-9782","observed_orcids":["https://orcid.org/0000-0002-2966-9782"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C V Borlongan","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9074,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.65138282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"58","issue":"3","first_page":"145","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/human-umbilical-cord-blood-cells","display_name":"human umbilical cord blood cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9029076099395752},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8106240034103394},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7859048247337341},{"id":"https://openalex.org/C64348767","wikidata":"https://www.wikidata.org/wiki/Q3335079","display_name":"Neuroregeneration","level":3,"score":0.6943469643592834},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6227293610572815},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3428138494491577},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32029062509536743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2620515525341034},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15186583995819092},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1188541054725647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:24844175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24844175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4117389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4117389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosurg Sci","raw_type":"Text"},{"id":"mag:2298255197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24844175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4117389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4117389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosurg Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2083106830","display_name":"Blood-Brain Barrier Repair in Cell Therapy for Stroke","funder_award_id":"R01NS071956","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109518992","https://openalex.org/W2108902553","https://openalex.org/W2760858292","https://openalex.org/W6989965423","https://openalex.org/W2181998537","https://openalex.org/W4230544186","https://openalex.org/W3036644731","https://openalex.org/W4253304901","https://openalex.org/W3131576484","https://openalex.org/W4214877276"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1],"injury":[2],"(TBI),":[3],"often":[4],"called":[5],"the":[6,59,106,131,158,186,193],"signature":[7],"wound":[8],"of":[9,41,71,112,130,136,143,147,178,188],"Iraq":[10],"and":[11,20,30,38,53,119,133,138,145,168,171],"Afghanistan":[12],"wars,":[13],"is":[14,92],"characterized":[15],"by":[16],"a":[17,39,95,109,162,174],"progressive":[18],"histopathology":[19],"long-lasting":[21],"behavioral":[22],"deficits.":[23],"Treatment":[24],"options":[25],"for":[26,51,98],"TBI":[27,79,152,170],"are":[28,32,180],"limited":[29],"patients":[31],"usually":[33],"relegated":[34],"to":[35,57,66,184],"rehabilitation":[36],"therapy":[37,111,150,191],"handful":[40],"experimental":[42],"treatments.":[43],"Stem":[44],"cell-based":[45],"therapies":[46],"offer":[47],"alternative":[48],"treatment":[49],"regimens":[50],"TBI,":[52,127],"have":[54],"been":[55],"intended":[56],"target":[58,177],"delayed":[60],"therapeutic":[61,176],"window":[62],"post-TBI,":[63],"in":[64,69,126,128,151,166,182,192],"order":[65,183],"promote":[67],"\"neuroregeneration,\"":[68],"lieu":[70],"\"neuroprotection\"":[72],"which":[73],"can":[74],"be":[75],"accomplished":[76],"during":[77],"acute":[78,167],"phase.":[80],"However,":[81],"these":[82],"interventions":[83],"may":[84],"require":[85],"adjunctive":[86],"pharmacological":[87],"treatments":[88],"especially":[89],"when":[90],"aging":[91],"considered":[93],"as":[94,161,173],"comorbidity":[96],"factor":[97,122],"post-TBI":[99],"health":[100],"outcomes.":[101],"Here,":[102],"we":[103],"put":[104],"forward":[105],"concept":[107],"that":[108],"combination":[110,149,190],"human":[113],"umbilical":[114],"cord":[115],"blood":[116],"cell":[117],"(hUCB)":[118],"granulocyte-colony":[120],"stimulating":[121],"(G-CSF)":[123],"attenuates":[124],"neuroinflammation":[125],"view":[129],"safety":[132],"efficacy":[134,146],"profiles":[135],"hUCB":[137],"G-CSF,":[139],"their":[140],"respective":[141],"mechanisms":[142],"action,":[144],"hUCB+G-CSF":[148,179],"animal":[153],"models.":[154],"Further":[155],"investigations":[156],"on":[157],"neuroinflammatory":[159],"pathway":[160],"key":[163],"pathological":[164],"hallmark":[165],"chronic":[169],"also":[172],"major":[175],"warranted":[181],"optimize":[185],"translation":[187],"this":[189],"clinic.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}