{"id":"https://openalex.org/W2298092255","doi":null,"title":"CRYOPRESERVATION OF HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS IN COMPLEX SUGAR BASED CRYOPROTECTIVE SOLUTIONS","display_name":"CRYOPRESERVATION OF HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS IN COMPLEX SUGAR BASED CRYOPROTECTIVE SOLUTIONS","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2298092255","mag":"2298092255"},"language":"en","primary_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/16947","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/16947","pdf_url":"https://dspace.lboro.ac.uk/2134/16947","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.lboro.ac.uk/2134/16947","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037464931","display_name":"Yahaira Naaldijk","orcid":"https://orcid.org/0000-0003-2701-3963","observed_orcids":["https://orcid.org/0000-0003-2701-3963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yahaira Naaldijk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2701-3963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058382675","display_name":"Viktoriya Federova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktoriya Federova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065423789","display_name":"Alexandra Stolzing","orcid":"https://orcid.org/0000-0002-2975-5736","observed_orcids":["https://orcid.org/0000-0002-2975-5736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Stolzing","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2975-5736","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2193,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.47539839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/umbilical-cord-derived-stem-cells","display_name":"umbilical cord-derived stem cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cryoprotectant-solutions","display_name":"cryoprotective solutions","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hydroxyethyl-starch","display_name":"hydroxyethyl starch","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sorbitol","display_name":"sorbitol","score":0.996999979019165},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":1.0},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/multilineage-differentiation","display_name":"multilineage differentiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8861781358718872},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.8404531478881836},{"id":"https://openalex.org/C68528507","wikidata":"https://www.wikidata.org/wiki/Q692267","display_name":"Cryoprotectant","level":4,"score":0.7746517658233643},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.6258658170700073},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6247401237487793},{"id":"https://openalex.org/C119577978","wikidata":"https://www.wikidata.org/wiki/Q913900","display_name":"Wharton's jelly","level":3,"score":0.4768684506416321},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46794313192367554},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.46294888854026794},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.4262763559818268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3912973701953888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36845895648002625},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35325711965560913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2871251702308655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1614668369293213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12791219353675842},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0674072802066803}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.lboro.ac.uk:2134/16947","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/16947","pdf_url":"https://dspace.lboro.ac.uk/2134/16947","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/9560918","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Cryopreservation_of_human_umbilical_cord-derived_mesenchymal_stem_cells_in_complex_sugar_based_cryoprotective_solutions/9560918","pdf_url":null,"source":{"id":"https://openalex.org/S4306402585","display_name":"Loughborough University Research Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"mag:2298092255","doi":null,"is_oa":false,"landing_page_url":"https://dspace.lboro.ac.uk/dspace-jspui/bitstream/2134/16947/3/Final%20paper%20hMSC%20cryo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/16947","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/16947","pdf_url":"https://dspace.lboro.ac.uk/2134/16947","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3156449723","display_name":null,"funder_award_id":"BMBF 1315883","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8604259724","display_name":"Translationszentrum f\u00fcr Regenerative Medizin - Leipzig (TRM): Molek\u00fcle und Zellen in der Geweberegeneration (2. F\u00f6rderphase)","funder_award_id":"1315883","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2298092255.pdf","grobid_xml":"https://content.openalex.org/works/W2298092255.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W1506233354"],"related_works":["https://openalex.org/W4405816693","https://openalex.org/W2027497562","https://openalex.org/W7019001831","https://openalex.org/W2920291569","https://openalex.org/W7028411038","https://openalex.org/W132804698","https://openalex.org/W1989914617","https://openalex.org/W7165594028","https://openalex.org/W4322737472","https://openalex.org/W4225849245"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1,63,89,142],"cells":[2,74],"(MSCs)":[3],"are":[4],"able":[5],"to":[6,15,49,69,84],"differentiate":[7],"in":[8,11],"vivo":[9],"and":[10,23,34,40,96,107,114,118,130,150],"vitro":[12],"giving":[13],"rise":[14],"different":[16],"cell":[17,53,64],"types":[18],"including":[19],"osteoblasts,":[20],"adipocytes,":[21],"chondrocytes":[22],"neuronal":[24],"cells,":[25],"providing":[26],"a":[27,79,85,103,123,147],"valuable":[28],"source":[29],"for":[30,42,62,136],"treatment":[31],"of":[32,38,52,87,105],"degenerative":[33],"age-associated":[35],"diseases.":[36],"Im-provement":[37],"protocols":[39],"procedures":[41],"human":[43,137],"MSCs":[44],"cryopreservation":[45,60],"will":[46],"contribute":[47],"significantly":[48],"the":[50,73,92],"development":[51],"replacement":[54],"therapies.":[55],"We":[56,120],"developed":[57],"an":[58],"alternative":[59],"solutions":[61],"cryopreservation.":[65],"Most":[66],"cryoprotectants":[67],"need":[68],"be":[70],"removed":[71],"from":[72],"by":[75],"washing":[76],"after":[77],"thawing,":[78],"procedure":[80,93],"that":[81,122],"can":[82],"lead":[83],"loss":[86],"precious":[88],"cells.":[90,143],"Additionally,":[91],"is":[94],"time":[95],"cost-consuming.":[97],"In":[98],"our":[99],"study":[100],"we":[101],"used":[102],"combination":[104],"transfusable":[106],"non-toxic":[108],"substances":[109],"such":[110],"as":[111],"hydroxyethylstarch,":[112],"sorbitol":[113,129],"dextran":[115,132],"replacing":[116],"DMSO":[117],"FCS.":[119],"found":[121],"cryosolution":[124],"containing":[125],"5%":[126,131],"HES,":[127],"0.3M":[128],"provide":[133],"successful":[134],"protection":[135],"umbilical":[138],"cord":[139],"derived":[140],"mesenchymal":[141],"These":[144],"MSC":[145],"retain":[146],"high":[148],"viability":[149],"show":[151],"multilineage":[152],"differentiation.":[153]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}