{"id":"https://openalex.org/W2297989013","doi":"https://doi.org/10.1021/acs.jmedchem.5b01909","title":"Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance","display_name":"Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance","publication_year":2016,"publication_date":"2016-03-17","ids":{"openalex":"https://openalex.org/W2297989013","doi":"https://doi.org/10.1021/acs.jmedchem.5b01909","mag":"2297989013","pmid":"https://pubmed.ncbi.nlm.nih.gov/26986178"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.5b01909","doi":"https://doi.org/10.1021/acs.jmedchem.5b01909","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5b01909","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031027218","display_name":"Kazimierz Wi\u015bniewski","orcid":"https://orcid.org/0000-0003-0002-5411","observed_orcids":["https://orcid.org/0000-0003-0002-5411"]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kazimierz Wi\u015bniewski","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030380407","display_name":"Javier Sueiras-Diaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Sueiras-Diaz","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039347285","display_name":"Guangcheng Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangcheng Jiang","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044394673","display_name":"Robert Galyean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Galyean","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053608706","display_name":"Mark Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Lu","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085499908","display_name":"Dorain Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorain Thompson","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037412173","display_name":"Yung-Chih Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yung-Chih Wang","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071579078","display_name":"Glenn E Croston","orcid":"https://orcid.org/0000-0002-6352-0922","observed_orcids":["https://orcid.org/0000-0002-6352-0922"]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Croston","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063804871","display_name":"Alexander P. Posch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Posch","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111925367","display_name":"Diane M. Hargrove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane M. Hargrove","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Halina Wi\u015bniewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Halina Wi\u015bniewska","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076791909","display_name":"R\u00e9gent Laporte","orcid":"https://orcid.org/0000-0002-9308-2097","observed_orcids":["https://orcid.org/0000-0002-9308-2097"]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R\u00e9gent Laporte","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049407180","display_name":"John J. Dwyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Dwyer","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090750835","display_name":"Steve Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Qi","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103413387","display_name":"Karthik Srinivasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthik Srinivasan","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042360760","display_name":"Jennifer Hartwig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Hartwig","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047349304","display_name":"Nicky Ferdyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicky Ferdyan","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080618293","display_name":"Monica Mares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Mares","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Kraus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kraus","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103623386","display_name":"Sudarkodi Alagarsamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudarkodi Alagarsamy","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028733131","display_name":"Pierre J.-M. Rivi\u00e8re","orcid":"https://orcid.org/0000-0002-8844-9130","observed_orcids":["https://orcid.org/0000-0002-8844-9130"]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre J. M. Rivi\u00e8re","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111630087","display_name":"Claudio D. Schteingart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279837","display_name":"Ferring Research Institute (United States)","ror":"https://ror.org/02375gf80","country_code":"US","type":"company","lineage":["https://openalex.org/I22138158","https://openalex.org/I4405279837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio D. Schteingart","raw_affiliation_strings":["Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferring\rResearch Institute Inc., 4245 Sorrento\rValley Boulevard, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4405279837"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031027218"],"corresponding_institution_ids":["https://openalex.org/I4405279837"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.537,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.81653252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"59","issue":"7","first_page":"3129","last_page":"3139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.4287000000476837,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-2","display_name":"glucagon-like peptide-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/glp-2-analog","display_name":"GLP-2 analog","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.781000018119812},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glucagon-receptor","display_name":"glucagon receptor","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hydrophobic-substitution","display_name":"hydrophobic substitution","score":0.6970000267028809},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.47999998927116394},{"id":"https://openalex.org/keywords/intestinal-diseases","display_name":"intestinal diseases","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9081236720085144},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.691253125667572},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5165845155715942},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5088267922401428},{"id":"https://openalex.org/C2781219945","wikidata":"https://www.wikidata.org/wiki/Q5572288","display_name":"Glucagon-like peptide-2","level":3,"score":0.45195215940475464},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.415517121553421},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3970780372619629},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32760846614837646},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30067622661590576},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27784693241119385},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.22725173830986023},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.1468886435031891},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.13735708594322205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067758","descriptor_name":"Glucagon-Like Peptide-2 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009646","descriptor_name":"Norleucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.5b01909","doi":"https://doi.org/10.1021/acs.jmedchem.5b01909","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5b01909","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:26986178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26986178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W32793180","https://openalex.org/W578326635","https://openalex.org/W1494795869","https://openalex.org/W1505786834","https://openalex.org/W1517135269","https://openalex.org/W1540078095","https://openalex.org/W1561204675","https://openalex.org/W1799473224","https://openalex.org/W1821870687","https://openalex.org/W1949183850","https://openalex.org/W1969501434","https://openalex.org/W1970107152","https://openalex.org/W1970713344","https://openalex.org/W1972990339","https://openalex.org/W1974095092","https://openalex.org/W1976968211","https://openalex.org/W1978182685","https://openalex.org/W2002149953","https://openalex.org/W2012325264","https://openalex.org/W2013395086","https://openalex.org/W2020558940","https://openalex.org/W2037235698","https://openalex.org/W2041556752","https://openalex.org/W2042990131","https://openalex.org/W2054748843","https://openalex.org/W2058112994","https://openalex.org/W2059944910","https://openalex.org/W2062561465","https://openalex.org/W2062616413","https://openalex.org/W2079711343","https://openalex.org/W2080622379","https://openalex.org/W2081576822","https://openalex.org/W2081901960","https://openalex.org/W2082633828","https://openalex.org/W2086564008","https://openalex.org/W2091773537","https://openalex.org/W2092344163","https://openalex.org/W2094375186","https://openalex.org/W2096425638","https://openalex.org/W2098309233","https://openalex.org/W2105194888","https://openalex.org/W2110584203","https://openalex.org/W2111901007","https://openalex.org/W2112512464","https://openalex.org/W2124850914","https://openalex.org/W2138867063","https://openalex.org/W2139129815","https://openalex.org/W2141426114","https://openalex.org/W2153421676","https://openalex.org/W2159620113","https://openalex.org/W2160940672","https://openalex.org/W2161957092","https://openalex.org/W2162105656","https://openalex.org/W2163456749","https://openalex.org/W2164408397","https://openalex.org/W2164835554","https://openalex.org/W2232494808","https://openalex.org/W2252868309","https://openalex.org/W2338218840","https://openalex.org/W2471713462","https://openalex.org/W2605224663","https://openalex.org/W2675921257","https://openalex.org/W3021245828","https://openalex.org/W4237798363","https://openalex.org/W4256152853"],"related_works":["https://openalex.org/W4406803078","https://openalex.org/W4320085847","https://openalex.org/W4385246430","https://openalex.org/W2496503361","https://openalex.org/W3097552634","https://openalex.org/W1980790007","https://openalex.org/W4406615437","https://openalex.org/W2082746738","https://openalex.org/W3216755774","https://openalex.org/W1977680116"],"abstract_inverted_index":{"Glucagon-like":[0],"peptide-2":[1],"receptor":[2,40,75,115],"agonists":[3,41],"have":[4],"therapeutic":[5],"potential":[6],"for":[7,96,165],"the":[8,78,83,97,107,110,138],"treatment":[9],"of":[10,38,48,102],"intestinal":[11],"diseases.":[12],"The":[13],"native":[14,111],"hGLP-2,":[15],"a":[16,24,46,163],"33":[17],"amino":[18],"acid":[19],"gastrointestinal":[20],"peptide,":[21],"is":[22],"not":[23],"suitable":[25],"clinical":[26,166],"candidate,":[27],"due":[28],"to":[29],"its":[30],"very":[31,118],"short":[32],"half-life":[33],"in":[34,58,64,92,147],"humans.":[35],"In":[36,73],"search":[37],"GLP-2":[39,49],"with":[42],"better":[43],"pharmacokinetic":[44],"characteristics,":[45],"series":[47],"analogues":[50],"containing":[51],"Gly":[52],"substitution":[53],"at":[54,77,106],"position":[55,59],"2,":[56],"norleucine":[57],"10,":[60],"and":[61,71,86,89,117,134,154],"hydrophobic":[62],"substitutions":[63],"positions":[65],"11":[66],"and/or":[67],"16":[68],"was":[69,160],"designed":[70],"synthesized.":[72],"vitro":[74],"potency":[76],"human":[79,84],"GLP-2,":[80],"selectivity":[81,116],"vs":[82,152],"GLP-1":[85],"GCG":[87],"receptors,":[88],"PK":[90],"profile":[91],"rats":[93],"were":[94,123],"determined":[95],"new":[98],"analogues.":[99],"A":[100],"number":[101],"compounds":[103],"more":[104],"potent":[105],"hGLP-2R":[108],"than":[109],"hormone,":[112],"showing":[113],"excellent":[114],"low":[119],"systemic":[120],"clearance":[121],"(CL)":[122],"discovered.":[124],"Analogues":[125],"69":[126],"([Gly(2),Nle(10),D-Thi(11),Phe(16)]hGLP-2-(1-30)-NH2),":[127],"72":[128],"([Gly(2),Nle(10),D-Phe(11),Leu(16)]hGLP-2-(1-33)-OH),":[129],"73":[130,157],"([Gly(2),Nle(10),D-Phe(11),Leu(16)]hGLP-2-(1-33)-NH2),":[131],"81":[132],"([Gly(2),Nle(10),D-Phe(11),Leu(16)]hGLP-2-(1-33)-NHEt),":[133],"85":[135],"([Gly(2),Nle(10),D-Phe(11),Leu(16)]hGLP-2-(1-33)-NH-((CH2)2O)4-(CH2)2-CONH2)":[136],"displayed":[137],"desired":[139],"profiles":[140],"(EC50":[141],"(hGLP-2R)":[142],"<":[143],"100":[144],"pM,":[145],"CL":[146],"rat":[148],"<0.3":[149],"mL/min/kg,":[150],"selective":[151],"hGLP-1R":[153],"hGCGR).":[155],"Compound":[156],"(FE":[158],"203799)":[159],"selected":[161],"as":[162],"candidate":[164],"development.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
