{"id":"https://openalex.org/W2297967082","doi":"https://doi.org/10.1007/978-3-319-22909-6_7","title":"Intratumor Heterogeneity in Breast Cancer","display_name":"Intratumor Heterogeneity in Breast Cancer","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2297967082","doi":"https://doi.org/10.1007/978-3-319-22909-6_7","mag":"2297967082","pmid":"https://pubmed.ncbi.nlm.nih.gov/26987535"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-22909-6_7","doi":"https://doi.org/10.1007/978-3-319-22909-6_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-22909-6_7","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2495271063","display_name":"Novel Biomarkers in the Continuum of Breast Cancer"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068484326","display_name":"Francisco Ferro de Be\u00e7a","orcid":"https://orcid.org/0000-0002-4409-012X","observed_orcids":["https://orcid.org/0000-0002-4409-012X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["PT","US"],"is_corresponding":true,"raw_author_name":"Francisco Beca","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA. francisco.beca@hms.harvard.edu","IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal. francisco.beca@hms.harvard.edu","Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA. francisco.beca@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal. francisco.beca@hms.harvard.edu","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014395742","display_name":"Korn\u00e9lia Poly\u00e1k","orcid":"https://orcid.org/0000-0002-5964-0382","observed_orcids":["https://orcid.org/0000-0002-5964-0382"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kornelia Polyak","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA","Department of Medicine, Brigham and Women's Hospital, Boston, USA","Department of Medicine, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068484326"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I182534213","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":null,"apc_paid":null,"fwci":25.3547,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.99853801,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"882","issue":null,"first_page":"169","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/epigenetic-heterogeneity","display_name":"epigenetic heterogeneity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5299999713897705},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.7628130316734314},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6057835817337036},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5961055159568787},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5562383532524109},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.5121419429779053},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5099395513534546},{"id":"https://openalex.org/C3018028425","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumor heterogeneity","level":3,"score":0.48826122283935547},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4857228398323059},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4854453206062317},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47200465202331543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4312545657157898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4029683470726013},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36387157440185547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23842081427574158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1677142083644867},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.13272202014923096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-319-22909-6_7","doi":"https://doi.org/10.1007/978-3-319-22909-6_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-22909-6_7","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:26987535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26987535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W43113016","https://openalex.org/W144631464","https://openalex.org/W1550678611","https://openalex.org/W1595203599","https://openalex.org/W1765129328","https://openalex.org/W1901855704","https://openalex.org/W1967304777","https://openalex.org/W1968655785","https://openalex.org/W1969803238","https://openalex.org/W1974685860","https://openalex.org/W1984807040","https://openalex.org/W1985384725","https://openalex.org/W1987012261","https://openalex.org/W1988720903","https://openalex.org/W1991061233","https://openalex.org/W1991872434","https://openalex.org/W1995143570","https://openalex.org/W1998811052","https://openalex.org/W2005895632","https://openalex.org/W2008934568","https://openalex.org/W2009886857","https://openalex.org/W2011907837","https://openalex.org/W2014444740","https://openalex.org/W2015255108","https://openalex.org/W2018288777","https://openalex.org/W2019199359","https://openalex.org/W2020131167","https://openalex.org/W2023915585","https://openalex.org/W2031770999","https://openalex.org/W2032518018","https://openalex.org/W2035310826","https://openalex.org/W2041142042","https://openalex.org/W2044433401","https://openalex.org/W2047941151","https://openalex.org/W2050086663","https://openalex.org/W2052244284","https://openalex.org/W2053443748","https://openalex.org/W2060822327","https://openalex.org/W2061401090","https://openalex.org/W2063382533","https://openalex.org/W2067664604","https://openalex.org/W2071877313","https://openalex.org/W2075082570","https://openalex.org/W2078495240","https://openalex.org/W2080264320","https://openalex.org/W2081769663","https://openalex.org/W2086239091","https://openalex.org/W2086828029","https://openalex.org/W2094649604","https://openalex.org/W2097255042","https://openalex.org/W2098043040","https://openalex.org/W2098970540","https://openalex.org/W2099139312","https://openalex.org/W2104159606","https://openalex.org/W2104316189","https://openalex.org/W2107270715","https://openalex.org/W2107773340","https://openalex.org/W2110612987","https://openalex.org/W2111510713","https://openalex.org/W2115358481","https://openalex.org/W2120869188","https://openalex.org/W2123562597","https://openalex.org/W2124870706","https://openalex.org/W2126903025","https://openalex.org/W2127340110","https://openalex.org/W2129288227","https://openalex.org/W2130601380","https://openalex.org/W2131994307","https://openalex.org/W2137853125","https://openalex.org/W2138188580","https://openalex.org/W2147354890","https://openalex.org/W2147984622","https://openalex.org/W2148323109","https://openalex.org/W2148847151","https://openalex.org/W2150575159","https://openalex.org/W2151948621","https://openalex.org/W2152228387","https://openalex.org/W2159414701","https://openalex.org/W2160003038","https://openalex.org/W2160076878","https://openalex.org/W2164629825","https://openalex.org/W2169895148","https://openalex.org/W2170490448","https://openalex.org/W2171708713","https://openalex.org/W2313344898","https://openalex.org/W2317072491","https://openalex.org/W2417585104","https://openalex.org/W2417902677","https://openalex.org/W2429744838","https://openalex.org/W2430708772","https://openalex.org/W2468893441","https://openalex.org/W4235642752","https://openalex.org/W4243667708","https://openalex.org/W4251104453","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W2098970540","https://openalex.org/W1992024850","https://openalex.org/W1964586143","https://openalex.org/W2773992597","https://openalex.org/W3028894483","https://openalex.org/W2125735327","https://openalex.org/W3106948063","https://openalex.org/W2069399470","https://openalex.org/W2468893441","https://openalex.org/W7201847844"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
