{"id":"https://openalex.org/W2297893802","doi":"https://doi.org/10.3109/09537104.2015.1119813","title":"Identification of novel Syk-independent functional roles of Fc\u03b3RIIa in platelet outside-in signaling using transgenic mice expressing human Fc\u03b3RIIa","display_name":"Identification of novel Syk-independent functional roles of Fc\u03b3RIIa in platelet outside-in signaling using transgenic mice expressing human Fc\u03b3RIIa","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2297893802","doi":"https://doi.org/10.3109/09537104.2015.1119813","mag":"2297893802","pmid":"https://pubmed.ncbi.nlm.nih.gov/26809427","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4975857"},"language":"en","primary_location":{"id":"doi:10.3109/09537104.2015.1119813","doi":"https://doi.org/10.3109/09537104.2015.1119813","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09537104.2015.1119813","pdf_url":null,"source":{"id":"https://openalex.org/S103305516","display_name":"Platelets","issn_l":"0953-7104","issn":["0953-7104","1369-1635"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4975857","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070012992","display_name":"Lorena Buitrago","orcid":"https://orcid.org/0000-0003-0116-6443","observed_orcids":["https://orcid.org/0000-0003-0116-6443"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorena Buitrago","raw_affiliation_strings":["Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011411239","display_name":"Bhanu Kanth Manne","orcid":"https://orcid.org/0000-0001-6848-4484","observed_orcids":["https://orcid.org/0000-0001-6848-4484"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhanu Kanth Manne","raw_affiliation_strings":["Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084910085","display_name":"Pierrette Andr\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierrette Andre","raw_affiliation_strings":["Cardeza Foundation and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardeza Foundation and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082480194","display_name":"Steven Edward McKenzie","orcid":"https://orcid.org/0000-0003-2654-8560","observed_orcids":["https://orcid.org/0000-0003-2654-8560"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven McKenzie","raw_affiliation_strings":["Cardeza Foundation and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardeza Foundation and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053757739","display_name":"Satya P. Kunapuli","orcid":"https://orcid.org/0000-0002-1298-3214","observed_orcids":["https://orcid.org/0000-0002-1298-3214"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya Kunapuli","raw_affiliation_strings":["Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070012992"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":4055,"currency":"AUD","value_usd":2970},"apc_paid":null,"fwci":0.3169,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66139075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"27","issue":"5","first_page":"488","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tyrosine-kinase-activation","display_name":"tyrosine kinase activation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8460000157356262},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.875}],"concepts":[{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.949060320854187},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6398423910140991},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6267526149749756},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5855592489242554},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5715888738632202},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5013091564178467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4980506896972656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4884280264377594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43407636880874634},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.42991501092910767},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38979965448379517},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25411564111709595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13270696997642517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12403228878974915},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.06539991497993469},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/09537104.2015.1119813","doi":"https://doi.org/10.3109/09537104.2015.1119813","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09537104.2015.1119813","pdf_url":null,"source":{"id":"https://openalex.org/S103305516","display_name":"Platelets","issn_l":"0953-7104","issn":["0953-7104","1369-1635"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"journal-article"},{"id":"pmid:26809427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26809427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:4975857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4975857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Platelets","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4975857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4975857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Platelets","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2463261764","display_name":"Regulation and function of PDK1-Akt-Pyk2 axis in platelets","funder_award_id":"R01HL118593","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2482875452","display_name":"Functional PKC Isoforms in Platelets","funder_award_id":"R01HL093231","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3047259921","display_name":"Pathogenesis and management of heparin-induced thrombocytopeneia","funder_award_id":"P01HL110860","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1540271729","https://openalex.org/W1604356365","https://openalex.org/W1643983504","https://openalex.org/W1968260614","https://openalex.org/W1982536372","https://openalex.org/W2003698382","https://openalex.org/W2050069950","https://openalex.org/W2075363343","https://openalex.org/W2076891149","https://openalex.org/W2081016687","https://openalex.org/W4313344679"],"related_works":["https://openalex.org/W2980136956","https://openalex.org/W2536584806","https://openalex.org/W2993141362","https://openalex.org/W2409498801","https://openalex.org/W2022851623","https://openalex.org/W2744761285","https://openalex.org/W2499191839","https://openalex.org/W2406886866","https://openalex.org/W2076891149","https://openalex.org/W2617696712"],"abstract_inverted_index":{"Platelet":[0],"outside-in":[1],"signaling":[2],"is":[3,25],"a":[4],"complex":[5],"and":[6],"dynamic":[7],"process":[8,24],"in":[9],"which":[10],"integrin":[11],"\u03b1IIb\u03b23":[12],"transmits":[13],"signals":[14],"to":[15],"the":[16,23,26],"actin":[17],"cytoskeleton.":[18],"An":[19],"important":[20],"part":[21],"of":[22,28],"activation":[27],"tyrosine":[29],"k...":[30]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}