{"id":"https://openalex.org/W2297614255","doi":"https://doi.org/10.1590/0074-02760150400","title":"Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species","display_name":"Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species","publication_year":2016,"publication_date":"2016-03-15","ids":{"openalex":"https://openalex.org/W2297614255","doi":"https://doi.org/10.1590/0074-02760150400","mag":"2297614255","pmid":"https://pubmed.ncbi.nlm.nih.gov/26982177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804502"},"language":"en","primary_location":{"id":"doi:10.1590/0074-02760150400","doi":"https://doi.org/10.1590/0074-02760150400","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760150400","pdf_url":"http://www.scielo.br/pdf/mioc/v111n3/0074-0276-mioc-0074-02760150400.pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scielo.br/pdf/mioc/v111n3/0074-0276-mioc-0074-02760150400.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025659255","display_name":"Danielly Beraldo dos Santos Silva","orcid":"https://orcid.org/0000-0002-3144-7476","observed_orcids":["https://orcid.org/0000-0002-3144-7476"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Danielly Beraldo dos Santos Silva","raw_affiliation_strings":["Universidade Federal da Grande Dourados, Brasil","Universidade Federal da Grande Dourados, Dourados, MS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Brasil","institution_ids":["https://openalex.org/I187420256"]},{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Dourados, MS, Brasil","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040896367","display_name":"Luana Mireli Carbonera Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luana Mireli Carbonera Rodrigues","raw_affiliation_strings":["Universidade Federal da Grande Dourados, Brasil","Universidade Federal da Grande Dourados, Dourados, MS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Brasil","institution_ids":["https://openalex.org/I187420256"]},{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Dourados, MS, Brasil","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074188083","display_name":"Adriana Ara\u00fajo de Almeida-Apolonio","orcid":"https://orcid.org/0000-0002-3836-8519","observed_orcids":["https://orcid.org/0000-0002-3836-8519"]},"institutions":[{"id":"https://openalex.org/I122558511","display_name":"Universidade Federal de Mato Grosso do Sul","ror":"https://ror.org/0366d2847","country_code":"BR","type":"education","lineage":["https://openalex.org/I122558511"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Ara\u00fajo de Almeida","raw_affiliation_strings":["Universidade Federal de Mato Grosso do Sul, Brasil","Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul, Brasil","institution_ids":["https://openalex.org/I122558511"]},{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil","institution_ids":["https://openalex.org/I122558511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027109449","display_name":"Kelly Mari Pires de Oliveira","orcid":"https://orcid.org/0000-0002-9897-7770","observed_orcids":["https://orcid.org/0000-0002-9897-7770","https://orcid.org/0000-0002-5473-8241"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kelly Mari Pires de Oliveira","raw_affiliation_strings":["Universidade Federal da Grande Dourados, Brasil","Universidade Federal da Grande Dourados, Dourados, MS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Brasil","institution_ids":["https://openalex.org/I187420256"]},{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Dourados, MS, Brasil","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032337504","display_name":"Alex\u00e9ia Barufatti","orcid":"https://orcid.org/0000-0001-8789-2117","observed_orcids":["https://orcid.org/0000-0001-8789-2117"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Alex\u00e9ia Barufatti Grisolia/","raw_affiliation_strings":["Universidade Federal da Grande Dourados, Brasil","Universidade Federal da Grande Dourados, Dourados, MS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Brasil","institution_ids":["https://openalex.org/I187420256"]},{"raw_affiliation_string":"Universidade Federal da Grande Dourados, Dourados, MS, Brasil","institution_ids":["https://openalex.org/I187420256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032337504"],"corresponding_institution_ids":["https://openalex.org/I187420256"],"apc_list":null,"apc_paid":null,"fwci":3.1094,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.90950299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"111","issue":"3","first_page":"192","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cyp51","display_name":"CYP51","score":0.9259999990463257},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.9679999947547913},{"id":"https://openalex.org/keywords/candida-krusei","display_name":"Candida krusei","score":1.0},{"id":"https://openalex.org/keywords/synonymous-mutations","display_name":"synonymous mutations","score":0.7829999923706055},{"id":"https://openalex.org/keywords/nonsynonymous-mutations","display_name":"non-synonymous mutations","score":0.996999979019165},{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.7850000262260437},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7160000205039978},{"id":"https://openalex.org/keywords/enzyme-function","display_name":"enzyme function","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.8309429883956909},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.771303653717041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7698744535446167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6342347264289856},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.6119550466537476},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6012312173843384},{"id":"https://openalex.org/C2781425774","wikidata":"https://www.wikidata.org/wiki/Q289229","display_name":"Candida krusei","level":4,"score":0.5863183736801147},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5840647220611572},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5770918130874634},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.5382521152496338},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47785136103630066},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.477020263671875},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.4636342227458954},{"id":"https://openalex.org/C195491092","wikidata":"https://www.wikidata.org/wiki/Q2717121","display_name":"Silent mutation","level":5,"score":0.42451798915863037},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.32802116870880127},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.2132147252559662},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.11967799067497253},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11259627342224121},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001393","descriptor_name":"Azoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D025141","descriptor_name":"Drug Resistance, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058886","descriptor_name":"Sterol 14-Demethylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065819","descriptor_name":"Voriconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1590/0074-02760150400","doi":"https://doi.org/10.1590/0074-02760150400","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760150400","pdf_url":"http://www.scielo.br/pdf/mioc/v111n3/0074-0276-mioc-0074-02760150400.pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4804502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem Inst Oswaldo Cruz","raw_type":"Text"},{"id":"pmid:26982177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26982177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Memorias do Instituto Oswaldo Cruz","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0074-02762016000300192","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300192","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.111 n.3 2016","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:cria:bioline:oc:oc16027","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=oc16027","pdf_url":null,"source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 111 Num 3","raw_type":"AA"},{"id":"pmh:oai:americanae.aecid.es:2706310","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2706310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.111 n.3 2016","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f5174fed0b284ed79a44242b444f2fd4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f5174fed0b284ed79a44242b444f2fd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Memorias do Instituto Oswaldo Cruz, Vol 111, Iss 3, Pp 192-199 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/0074-02760150400","doi":"https://doi.org/10.1590/0074-02760150400","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760150400","pdf_url":"http://www.scielo.br/pdf/mioc/v111n3/0074-0276-mioc-0074-02760150400.pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320323354","display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","ror":"https://ror.org/05jtrt935"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2297614255.pdf","grobid_xml":"https://content.openalex.org/works/W2297614255.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1534406401","https://openalex.org/W1653248413","https://openalex.org/W1851369101","https://openalex.org/W1883512222","https://openalex.org/W1905535572","https://openalex.org/W1982447955","https://openalex.org/W1995170603","https://openalex.org/W1997538444","https://openalex.org/W2000559685","https://openalex.org/W2023040201","https://openalex.org/W2034131452","https://openalex.org/W2034450582","https://openalex.org/W2067803048","https://openalex.org/W2070892499","https://openalex.org/W2093097787","https://openalex.org/W2093801207","https://openalex.org/W2096420865","https://openalex.org/W2097706568","https://openalex.org/W2099674708","https://openalex.org/W2107043911","https://openalex.org/W2112936110","https://openalex.org/W2115223992","https://openalex.org/W2116151269","https://openalex.org/W2122550330","https://openalex.org/W2128394219","https://openalex.org/W2135021455","https://openalex.org/W2137015675","https://openalex.org/W2138270253","https://openalex.org/W2141563676","https://openalex.org/W2144461882","https://openalex.org/W2147757952","https://openalex.org/W2148454645","https://openalex.org/W2148847026","https://openalex.org/W2149199207","https://openalex.org/W2151649073","https://openalex.org/W2152207030","https://openalex.org/W2157846113","https://openalex.org/W2166190629","https://openalex.org/W2166265186","https://openalex.org/W4299735549","https://openalex.org/W7096257995"],"related_works":["https://openalex.org/W2071718406","https://openalex.org/W4414350679","https://openalex.org/W2151649073","https://openalex.org/W2363151190","https://openalex.org/W2221865045","https://openalex.org/W2381875470","https://openalex.org/W7097239802","https://openalex.org/W2374843547","https://openalex.org/W2040810699","https://openalex.org/W1603981109"],"abstract_inverted_index":{"The":[0,42,105,118],"azoles":[1],"are":[2],"the":[3,30,34,38,52,77,81,96,129,136,145,153,160,163,182],"class":[4],"of":[5,40,44,55,61,83,98,108,156,162,167,184],"medications":[6],"most":[7],"commonly":[8],"used":[9],"to":[10,22,48,65,68,134,150,181],"fight":[11],"infections":[12],"caused":[13],"by":[14],"Candida":[15,62,84,99,190],"sp.":[16],"Typically,":[17],"resistance":[18],"can":[19],"be":[20,66],"attributed":[21],"mutations":[23,50,75,94,111],"in":[24,51,58,76,80,95,152,165,172],"ERG11":[25,78],"gene":[26,57,79],"(CYP51)":[27],"which":[28],"encodes":[29],"cytochrome":[31],"P450":[32],"14\u03b1-demethylase,":[33],"primary":[35],"target":[36],"for":[37],"activity":[39],"azoles.":[41,69],"objective":[43],"this":[45],"study":[46],"was":[47,112,132],"identify":[49],"coding":[53],"region":[54],"theERG11":[56],"clinical":[59,154],"isolates":[60,82,97],"species":[63],"known":[64],"resistant":[67,189],"We":[70],"identified":[71],"three":[72],"new":[73,92,185],"synonymous":[74],"glabrata":[85],"(C108G,":[86],"C423T":[87],"and":[88,90,102,147],"A1581G)":[89],"two":[91],"nonsynonymous":[93,110],"krusei--A497C":[100],"(Y166S)":[101],"G1570A":[103],"(G524R).":[104],"functional":[106],"consequence":[107],"these":[109],"predicted":[113],"using":[114],"evolutionary":[115],"conservation":[116],"scores.":[117],"G524R":[119],"mutation":[120,131,146],"did":[121],"not":[122],"have":[123],"effect":[124],"on":[125],"14\u03b1-demethylase":[126],"functionality,":[127],"while":[128],"Y166S":[130,164],"found":[133],"affect":[135],"enzyme.":[137],"This":[138],"observation":[139],"suggests":[140],"a":[141],"possible":[142],"link":[143],"between":[144],"dose-dependent":[148],"sensitivity":[149,170],"voriconazole":[151],"isolate":[155,173],"C.":[157,174],"krusei.":[158],"Although":[159],"presence":[161],"phenotype":[166],"reduced":[168],"azole":[169],"observed":[171],"krusei":[175],"demands":[176],"investigation,":[177],"it":[178],"might":[179],"contribute":[180],"search":[183],"therapeutic":[186],"agents":[187],"against":[188],"isolates.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}