{"id":"https://openalex.org/W2297550839","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","title":"Efficacy of preoperative radiochemotherapy in patients with locally advanced pancreatic carcinoma","display_name":"Efficacy of preoperative radiochemotherapy in patients with locally advanced pancreatic carcinoma","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2297550839","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","mag":"2297550839"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.15073","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104000961","display_name":"Pehr Lind","orcid":"https://orcid.org/0000-0001-7565-8980","observed_orcids":["https://orcid.org/0000-0001-7565-8980"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P. A. Lind","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054249","display_name":"B. Isaksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B. Isaksson","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037080469","display_name":"Markus Almstr\u00f6m","orcid":"https://orcid.org/0000-0001-6035-735X","observed_orcids":["https://orcid.org/0000-0001-6035-735X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Almstr\u00f6m","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067901779","display_name":"Anders Johnsson","orcid":"https://orcid.org/0000-0002-2457-3175","observed_orcids":["https://orcid.org/0000-0002-2457-3175"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Johnsson","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017774819","display_name":"Nils Albiin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"N. Albiin","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614070","display_name":"Per Bystr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P. Bystr\u00f6m","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082356752","display_name":"Johan Permert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Permert","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden; University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"15073","last_page":"15073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-pancreatic-cancer","display_name":"locally advanced pancreatic cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.8100000023841858},{"id":"https://openalex.org/keywords/resectability","display_name":"resectability","score":0.5379999876022339},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/three-dimensional-conformal-radiotherapy","display_name":"3D conformal radiotherapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6050000190734863},{"id":"https://openalex.org/keywords/r0-resection","display_name":"R0 resection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/perioperative-morbidity","display_name":"perioperative morbidity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9791672229766846},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.7153971791267395},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5729243755340576},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5202373266220093},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5168238282203674},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4248819649219513},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3389565348625183},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33213290572166443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2765878438949585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.15073","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15073","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001077302","https://openalex.org/W2008438741","https://openalex.org/W1979451580","https://openalex.org/W2294867706","https://openalex.org/W2581767333","https://openalex.org/W2805624157","https://openalex.org/W3169253960","https://openalex.org/W3008190574","https://openalex.org/W2088391956","https://openalex.org/W2425810744"],"abstract_inverted_index":{"15073":[0],"Background:":[1],"The":[2,50,86,173,243],"optimal":[3],"care":[4],"for":[5,27,40,69,83,146,165,177,196],"patients":[6,36,51,137,162,192,256],"with":[7,20,34,115,144,155,187,257],"irresectable,":[8,55],"non-metastatic":[9,56],"pancreatic":[10],"carcinoma":[11],"(PAC)":[12],"is":[13],"debated.":[14],"We":[15],"treated":[16],"17":[17],"consecutive":[18],"cases":[19,126,152],"preop":[21,87],"radiochemotherapy":[22],"(RCT)":[23],"as":[24],"a":[25,65,70,80,170,263],"means":[26],"downstaging":[28],"their":[29],"tumors":[30],"and":[31,141,167,228,269],"compared":[32,185],"outcome":[33],"35":[35],"undergoing":[37,193],"direct":[38,194],"surgery":[39,147,166,195,220],"primarily":[41,197],"resectable":[42,198],"PAC":[43,57,199,260],"during":[44],"the":[45,62,77,139,159,178,213,217,229,241],"same":[46],"time":[47],"period.":[48],"Methods:":[49],"had":[52],"biopsy":[53],"proven,":[54],"which":[58,184,286],"engaged":[59],">50%":[60],"of":[61,64,76,79,92,127,191,219,266],"circumference":[63,78],"patent":[66],"mesenteric/portal":[67],"vein":[68],"distance":[71],">2":[72],"cm":[73],"and/or":[74],"<50%":[75],"regional":[81],"artery":[82],"<2":[84],"cm.":[85],"therapy":[88],"included":[89],"2":[90,100],"courses":[91],"Xelox":[93,117],"(oxaliplatin":[94],"130mg/m2":[95],"d1;":[96],"capecitabine":[97],"1000mg/m2":[98],"X":[99,122],"d1\u201314":[101],"q":[102,119],"3":[103],"w)":[104],"followed":[105],"by":[106],"3-D":[107],"conformal":[108],"radiotherapy":[109],"(50.4":[110],"Gy;":[111],"1.8":[112],"Gy":[113],"fractions)":[114],"reduced":[116],"(d1\u20135":[118],"1":[120],"w":[121],"6).":[123],"Results:":[124],"6":[125],"RCT-related":[128],"CTC":[129],"Grade":[130],"3\u20134":[131],"non-hematologic":[132],"side-effects":[133],"were":[134,142,153,163],"diagnosed.":[135],"Sixteen":[136],"completed":[138],"RCT":[140,253],"rescanned":[143],"CT/reevaluated":[145],"4":[148],"weeks":[149],"post-RCT.":[150],"Five":[151],"diagnosed":[154],"new":[156,284],"metastases":[157],"to":[158,297],"liver.":[160],"Eleven":[161],"accepted":[164],"8":[168],"underwent":[169],"curative":[171,267],"R0-resection.":[172],"median":[174,271],"overall":[175],"survival":[176,272],"latter":[179],"group":[180,190],"was":[181,210,221,233,246],"29":[182],"mos,":[183],"favorably":[186],"our":[188,274,291],"control":[189],"(median":[200],"OS:":[201],"16":[202],"mos":[203],"(P=0.02).":[204],"RO-":[205],"rate:":[206],"75%).":[207],"Periop":[208],"morbidity":[209],"similar":[211],"in":[212,240,248,254,262,273,283],"two":[214],"cohorts":[215],"but":[216],"duration":[218],"longer":[222],"(576":[223],"vs":[224,236],"477":[225],"min;":[226],"P<0.05)":[227,239],"op":[230],"blood":[231],"loss":[232],"greater":[234],"(3288":[235],"1460":[237],"ml;":[238],"RCT-cohort.":[242],"30-day":[244],"mortality":[245],"zero":[247],"both":[249],"cohorts.":[250],"Conclusions:":[251],"Preop":[252],"fit":[255],"locally":[258],"advanced":[259],"resulted":[261],"high":[264],"rate":[265],"resections":[268],"promising":[270],"treatment":[275],"series.":[276],"This":[277],"trimodality":[278],"approach":[279],"merits":[280],"further":[281],"exploration":[282],"studies,":[285],"are":[287],"currently":[288],"underway":[289],"at":[290],"Department.":[292],"No":[293],"significant":[294],"financial":[295],"relationships":[296],"disclose.":[298]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}