{"id":"https://openalex.org/W2297522620","doi":null,"title":"Ein hoher Mitochondriengehalt korreliert mit der Progression des Prostatakarzinoms","display_name":"Ein hoher Mitochondriengehalt korreliert mit der Progression des Prostatakarzinoms","publication_year":2016,"publication_date":"2016-03-08","ids":{"openalex":"https://openalex.org/W2297522620","mag":"2297522620"},"language":"de","primary_location":{"id":"mag:2297522620","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2016/7786/index.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070224526","display_name":"Karolina Jedrzejewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karolina Jedrzejewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070224526"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00713636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mitochondrial-content","display_name":"mitochondrial content","score":0.7829999923706055},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/erg-fusion","display_name":"ERG fusion","score":0.7680000066757202},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pten-deletion","display_name":"PTEN deletion","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tissue-microarray","display_name":"tissue microarray","score":0.8130000233650208},{"id":"https://openalex.org/keywords/surgical-resection-margin","display_name":"surgical resection margin","score":0.656000018119812},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.4690000116825104},{"id":"https://openalex.org/keywords/genomic-deletions","display_name":"genomic deletions","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7132031917572021},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7090702652931213}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2297522620","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2016/7786/index.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W160766925","https://openalex.org/W1495423002","https://openalex.org/W1589421810","https://openalex.org/W1963749564","https://openalex.org/W1965587273","https://openalex.org/W1966170654","https://openalex.org/W1966522008","https://openalex.org/W1966559042","https://openalex.org/W1969947723","https://openalex.org/W1975854213","https://openalex.org/W1983704893","https://openalex.org/W1984621921","https://openalex.org/W1989294105","https://openalex.org/W1998566859","https://openalex.org/W2003959002","https://openalex.org/W2006974639","https://openalex.org/W2008107855","https://openalex.org/W2011784034","https://openalex.org/W2012306090","https://openalex.org/W2012523643","https://openalex.org/W2014542098","https://openalex.org/W2016815316","https://openalex.org/W2017881185","https://openalex.org/W2022101765","https://openalex.org/W2026096282","https://openalex.org/W2028268047","https://openalex.org/W2047367472","https://openalex.org/W2051718124","https://openalex.org/W2052543023","https://openalex.org/W2054074987","https://openalex.org/W2055653739","https://openalex.org/W2057260482","https://openalex.org/W2058403800","https://openalex.org/W2060003051","https://openalex.org/W2067511583","https://openalex.org/W2068870756","https://openalex.org/W2081194505","https://openalex.org/W2091481108","https://openalex.org/W2102799140","https://openalex.org/W2105020598","https://openalex.org/W2107633226","https://openalex.org/W2115020724","https://openalex.org/W2117458812","https://openalex.org/W2121158863","https://openalex.org/W2121727754","https://openalex.org/W2127049578","https://openalex.org/W2129583552","https://openalex.org/W2142924577","https://openalex.org/W2146191095","https://openalex.org/W2157258452","https://openalex.org/W2159715390","https://openalex.org/W2163069284","https://openalex.org/W2168330194","https://openalex.org/W2168471784","https://openalex.org/W2169883357","https://openalex.org/W2172123503","https://openalex.org/W2256368028","https://openalex.org/W2326949580"],"related_works":["https://openalex.org/W2095912264","https://openalex.org/W7095815056","https://openalex.org/W4404723321","https://openalex.org/W2770835670","https://openalex.org/W7095839138","https://openalex.org/W2604527175","https://openalex.org/W2550214706","https://openalex.org/W2590417299","https://openalex.org/W2413844139","https://openalex.org/W3194321913"],"abstract_inverted_index":{"Mitochondrien":[0,36],"wird":[1],"eine":[2,49],"Schlusselrolle":[3],"bei":[4,8,120,230],"der":[5,9,33,85,102,121,150,152,197,231],"Entstehung":[6],"und":[7,75,90,99,118,139,169,174,222],"Progression":[10],"von":[11,21,35,171],"Krebserkrankungen":[12],"zugesprochen.":[13],"Diese":[14],"Studie":[15],"evaluierte":[16],"die":[17,31,38,207,210,224],"potentielle":[18],"prognostische":[19],"Relevanz":[20],"MTC02,":[22,257],"einem":[23,46,53,126,177,217],"Biomarker":[24],"fur":[25,37,192],"den":[26,157],"Mitochondriengehalt":[27],"beim":[28],"Prostatakarzinom.":[29],"Um":[30],"Bedeutung":[32],"Quantitat":[34],"Prognose":[39],"des":[40,142,228,233],"Prostatakarzinoms":[41],"zu":[42,91,95,100],"untersuchen,":[43],"wurde":[44,82],"in":[45,83,113,199,216,263,318,417,425,449],"immunhistochemischen":[47],"Verfahren":[48],"MTC02":[50,167,184,271,308,314,338,387,414,423,439],"Antikorperfarbung":[51],"auf":[52],"TMA":[54,301],"mit":[55,66,125,149],"insgesamt":[56],"11.152":[57],"Tumorproben":[58],"durchgefuhrt.":[59],"Die":[60,145],"Ergebnisse":[61],"dieser":[62],"Farbung":[63,168],"wurden":[64],"anschliesend":[65],"dem":[67,70,73],"histologischen":[68],"Phanotyp,":[69],"biochemischen":[71,179],"Rezidiv,":[72],"ERG-Fusionstyp":[74],"weiteren":[76],"genomischen":[77],"Deletionen":[78,170],"verglichen.":[79],"Eine":[80,108],"MTC02-Antikorperfarbung":[81],"96,5%":[84],"8.412":[86],"analysierbaren":[87],"Prostatakrebsgewebeproben":[88],"nachgewiesen":[89],"15,4%":[92],"als":[93,97,104,188],"schwach,":[94],"34,6%":[96],"moderat":[98],"46,5%":[101],"Falle":[103],"stark":[105],"exprimiert":[106],"gewertet.":[107],"signifikant":[109],"starkere":[110],"Expression":[111],"konnte":[112,221],"malignem":[114],"Prostatagewebe":[115],"gemessen":[116],"werden":[117],"korrelierte":[119],"Untersuchung":[122],"aller":[123],"Prostatakarzinome":[124],"fortgeschrittenen":[127],"Tumorstadium,":[128],"hohen":[129],"Gleason":[130,348],"Grad,":[131],"Lymphknotenmetastasen":[132],"(jeweils":[133,182],"p<0,0001),":[134],"positiven":[135],"chirurgischen":[136],"Resektionsrand":[137],"(p=0,0005)":[138],"fruhen":[140,178],"Wiederanstieg":[141],"PSA-Werts":[143],"(p<0,0001).":[144,155],"MTC02-Expression":[146,211],"war":[147,160],"assoziiert":[148],"Untergruppe":[151],"ERG-positiven":[153],"Prostatatumoren":[154,201],"In":[156,381],"ERG-negativen":[158,200],"Prostatakarzinomen":[159],"ein":[161,189,212],"signifikanter":[162],"Zusammenhang":[163],"zwischen":[164],"einer":[165],"starken":[166],"PTEN-,":[172],"6q15-":[173],"5q21-Deletionen":[175],"sowie":[176],"Rezidiv":[180],"nachweisbar":[181],"p<0,0001).":[183],"stellte":[185],"sich":[186],"schlieslich":[187],"aussagekraftiger":[190],"Pradiktor":[191],"einen":[193],"ungunstigen":[194],"klinischen":[195],"Verlauf":[196],"Krebserkrankung":[198],"heraus.":[202],"Erganzende":[203],"multivariate":[204,407],"Analysen":[205],"bestatigten":[206],"Annahme,":[208],"dass":[209],"unabhangiger":[213],"prognostischer":[214],"Marker":[215],"praoperativen":[218],"Setting":[219],"sein":[220],"unterstreichen":[223],"potentiell":[225],"wichtige":[226],"Rolle":[227],"Mitochondriengehaltes":[229],"Zellbiologie":[232],"Prostatakarzinoms.":[234],"\nBackground\r\nMitochondria":[235],"are":[236],"suggested":[237,409],"to":[238,251,287,391],"be":[239],"important":[240,456],"organelles":[241],"for":[242,260,462],"cancer":[243,282,464],"initiation":[244],"and":[245,294,333,358,397,435],"promotion.":[246],"This":[247],"study":[248,420],"was":[249,272,316,340,389],"designed":[250],"evaluate":[252],"the":[253],"prognostic":[254],"value":[255],"of":[256,266,320,393,406,413,432,445,458],"a":[258,275,442,454],"marker":[259],"mitochondrial":[261,460],"content,":[262],"prostate":[264,281,312,323,384,428,463],"cancer.\r\n\r\nMethods\r\nImmunohistochemistry":[265],"using":[267,299],"an":[268,410],"antibody":[269],"against":[270],"performed":[273],"on":[274],"tissue":[276],"microarray":[277],"(TMA)":[278],"containing":[279],"11,152":[280],"specimens.":[283],"Results":[284],"were":[285,366],"compared":[286],"histological":[288],"phenotype,":[289],"biochemical":[290,399],"recurrence,":[291],"ERG":[292,371,382,426,450],"status":[293],"other":[295],"genomic":[296],"deletions":[297,392,431],"by":[298],"our":[300],"attached":[302],"molecular":[303],"information.\r\n\r\nResults\r\nTumor":[304],"cells":[305],"showed":[306,373],"stronger":[307],"expression":[309,339,375,424,440],"than":[310,377],"normal":[311],"epithelium.":[313],"immunostaining":[315,388],"found":[317],"96.5%":[319],"8,412":[321],"analyzable":[322],"cancers,":[324,385,452],"including":[325],"15.4%":[326],"tumors":[327],"with":[328,331,335,342,415],"weak,":[329],"34.6%":[330],"moderate,":[332],"46.5%":[334],"strong":[336,386,443],"expression.":[337],"associated":[341],"advanced":[343],"pathological":[344],"tumor":[345],"stage,":[346],"high":[347],"score,":[349],"nodal":[350],"metastases":[351],"(p\u2009<\u20090.0001":[352,401],"each),":[353],"positive":[354],"surgical":[355],"margins":[356],"(p\u2009=\u20090.0005),":[357],"early":[359,398],"PSA":[360],"recurrence":[361,400],"(p\u2009<\u20090.0001)":[362],"if":[363],"all":[364],"cancers":[365,429],"jointly":[367],"analyzed.":[368],"Tumors":[369],"harboring":[370,430],"fusion":[372],"higher":[374],"levels":[376],"those":[378],"without":[379],"(p\u2009<\u20090.0001).":[380],"negative":[383,427,451],"linked":[390],"PTEN,":[394,433],"6q15,":[395,434],"5q21,":[396],"each).":[402],"Moreover,":[403],"multiple":[404],"scenarios":[405],"analyses":[408],"independent":[411],"association":[412],"prognosis":[416],"preoperative":[418],"settings.\r\n\r\nConclusions\r\nOur":[419],"demonstrates":[421],"high-level":[422],"5q21.":[436],"Additionally,":[437],"increased":[438],"is":[441],"predictor":[444],"poor":[446],"clinical":[447],"outcome":[448],"highlighting":[453],"potentially":[455],"role":[457],"elevated":[459],"content":[461],"cell":[465],"biology.":[466]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
