{"id":"https://openalex.org/W2297277033","doi":null,"title":"Adipocytokines and aging: adiponectin and leptin.","display_name":"Adipocytokines and aging: adiponectin and leptin.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W2297277033","mag":"2297277033","pmid":"https://pubmed.ncbi.nlm.nih.gov/23732375"},"language":"en","primary_location":{"id":"pmid:23732375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008672486","display_name":"Ne\u015fe Ers\u00f6z G\u00fcl\u00e7elik","orcid":"https://orcid.org/0000-0001-8212-5752","observed_orcids":["https://orcid.org/0000-0001-8212-5752"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"N E Gulcelik","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Hacettepe Medical School, Ankara, Turkey. neseersoz@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Hacettepe Medical School, Ankara, Turkey. neseersoz@hotmail.com","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038557286","display_name":"Meltem Gulhan Halil","orcid":"https://orcid.org/0000-0001-7597-8140","observed_orcids":["https://orcid.org/0000-0001-7597-8140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Halil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026168989","display_name":"Servet Ar\u0131o\u011ful","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ariogul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039906910","display_name":"Aydan Usman","orcid":"https://orcid.org/0000-0002-2078-264X","observed_orcids":["https://orcid.org/0000-0002-2078-264X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Usman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1271,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94290558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"2","first_page":"203","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9919999837875366},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.9150000214576721},{"id":"https://openalex.org/keywords/subcutaneous-fat-reduction","display_name":"subcutaneous fat loss","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fat-redistribution","display_name":"fat redistribution","score":0.8410000205039978},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5920000076293945},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6150000095367432},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.7760000228881836},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8169999718666077},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9598977565765381},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.9489739537239075},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8291393518447876},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8042231202125549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8035634756088257},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.789546012878418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7570319175720215},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.48866894841194153},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2963831126689911},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.16437700390815735}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23732375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},{"id":"mag:2297277033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393188908","https://openalex.org/W2921600589","https://openalex.org/W2083848415","https://openalex.org/W4407159853","https://openalex.org/W7128729999","https://openalex.org/W2290054275","https://openalex.org/W2921426813","https://openalex.org/W205077307","https://openalex.org/W2059879341","https://openalex.org/W4300875113"],"abstract_inverted_index":{"Adipose":[0],"tissue":[1,45],"is":[2,24,30,46,85,112,164,208],"an":[3,86],"active":[4],"metabolic":[5,53],"organ":[6],"secreting":[7],"adipocytokines":[8,235],"which":[9,29,71],"are":[10],"involved":[11,48],"in":[12,49,75,102,120,142,158,239],"the":[13,50,62,76,82,185,193,230,240],"energy":[14],"homeostasis":[15],"and":[16,20,38,66,79,90,204,237,243],"regulation":[17],"of":[18,34,40,52,68,81,118,128,130,170,182,187,195,219,232],"glucose":[19],"lipid":[21],"metabolism.":[22],"Aging":[23,59,207],"associated":[25,98,113,210],"with":[26,99,114,211],"fat":[27,37],"redistribution,":[28],"characterized":[31],"by":[32],"loss":[33,127],"peripheral":[35],"subcutaneous":[36,56],"accumulation":[39],"visceral":[41],"fat.":[42],"Visceral":[43],"adipose":[44,57,69],"more":[47,109],"developement":[51],"diseases":[54,199],"than":[55,148],"tissue.":[58],"also":[60,192,209],"alters":[61],"function,":[63],"proliferation,":[64],"size,":[65],"number":[67],"cells":[70],"leads":[72],"to":[73,126,136,155,213,216],"alterations":[74],"secretion,":[77],"synthesis":[78],"function":[80,129],"adipocytokines.":[83],"Adiponectin":[84],"insulin":[87],"sensitizing,":[88],"anti-inflammatory,":[89],"antiathoregenic":[91],"adipokine.":[92],"Centarians":[93],"have":[94,178],"higher":[95,115],"adiponectin":[96,111,119,132,143,151,236],"levels":[97,144,152],"longevity.":[100],"However,":[101],"older":[103,121,159],"individuals":[104,122],"\u2011":[105,110],"age":[106],"65":[107],"or":[108,133],"mortality.":[116],"Dysregulation":[117],"may":[123,153],"be":[124],"due":[125],"circulating":[131],"a":[134,168,217],"response":[135],"increased":[137,156],"inflammatory":[138],"process.":[139],"Longitidunal":[140],"increase":[141],"5with":[145],"aging":[146,188,241],"rather":[147],"genetically":[149],"high":[150],"translate":[154],"mortality":[157],"patients.":[160],"The":[161],"adipocytokine":[162],"leptin":[163,196,214,238],"traditionally":[165],"viewed":[166],"as":[167],"product":[169],"adipocytes":[171],"that":[172],"can":[173],"exert":[174],"endocrine":[175],"effects.":[176],"There":[177],"been":[179],"conflicting":[180],"reports":[181],"not":[183],"only":[184],"effects":[186,194],"on":[189,197],"leptin,":[190],"but":[191],"age-related":[198,244],"including":[200],"sarcopenia,":[201],"Alzheimer's":[202],"disease":[203],"cardiovascular":[205],"diseases.":[206,245],"resistance":[212],"and/or":[215],"decrease":[218],"receptors":[220],"for":[221],"this":[222,225],"hormone.":[223],"In":[224],"review,":[226],"we":[227],"briefly":[228],"discuss":[229],"role":[231],"two":[233],"major":[234],"process":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}