{"id":"https://openalex.org/W2297084643","doi":"https://doi.org/10.1093/ofid/ofv133.223","title":"Non-clonal Outbreak of Burkholderia Cepacia Complex in the Intensive Care Unit Confirmed by Genomic Analysis and Eradicated After Terminal Cleaning of the Unit","display_name":"Non-clonal Outbreak of Burkholderia Cepacia Complex in the Intensive Care Unit Confirmed by Genomic Analysis and Eradicated After Terminal Cleaning of the Unit","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2297084643","doi":"https://doi.org/10.1093/ofid/ofv133.223","mag":"2297084643"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofv133.223","doi":"https://doi.org/10.1093/ofid/ofv133.223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.223","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofv133.223","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073111134","display_name":"Rabea Khedimi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabea Khedimi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074546960","display_name":"Gopi Patel","orcid":"https://orcid.org/0000-0003-1877-5608","observed_orcids":["https://orcid.org/0000-0003-1877-5608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gopi Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081085535","display_name":"Roopa D. Kohli-Seth","orcid":"https://orcid.org/0000-0002-6082-1359","observed_orcids":["https://orcid.org/0000-0002-6082-1359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roopa Kohli-Seth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079673052","display_name":"Camille L. A. Hamula","orcid":"https://orcid.org/0000-0002-9246-7980","observed_orcids":["https://orcid.org/0000-0002-9246-7980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camille Hamula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041321709","display_name":"Theodore R. Pak","orcid":"https://orcid.org/0000-0002-1676-2523","observed_orcids":["https://orcid.org/0000-0002-1676-2523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore Pak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081285167","display_name":"Deena R. Altman","orcid":"https://orcid.org/0000-0003-1948-3834","observed_orcids":["https://orcid.org/0000-0003-1948-3834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deena Altman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Martha Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth Somers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Somers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076788078","display_name":"Robert Sebra","orcid":"https://orcid.org/0000-0001-9267-2426","observed_orcids":["https://orcid.org/0000-0001-9267-2426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Sebra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060689942","display_name":"Harm van Bakel","orcid":"https://orcid.org/0000-0002-1376-6916","observed_orcids":["https://orcid.org/0000-0002-1376-6916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harm Van Bakel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008757230","display_name":"Ali Bashir","orcid":"https://orcid.org/0000-0002-5240-9604","observed_orcids":["https://orcid.org/0000-0002-5240-9604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Bashir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032714338","display_name":"Andrew Kasarskis","orcid":"https://orcid.org/0000-0001-6454-9076","observed_orcids":["https://orcid.org/0000-0001-6454-9076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Kasarskis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009119735","display_name":"Fran Wallach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran Wallach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013145121","display_name":"Shirish S. Huprikar","orcid":"https://orcid.org/0000-0001-7151-7830","observed_orcids":["https://orcid.org/0000-0001-7151-7830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shirish Huprikar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17382042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.16740000247955322,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burkholderia-cepacia-complex","display_name":"Burkholderia cepacia complex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hospital-outbreak","display_name":"hospital outbreak","score":0.875},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.9399999976158142},{"id":"https://openalex.org/keywords/terminal-cleaning","display_name":"terminal cleaning","score":0.7170000076293945},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"whole genome sequencing","score":0.9160000085830688},{"id":"https://openalex.org/keywords/environmental-culture","display_name":"environmental culture","score":0.4230000078678131},{"id":"https://openalex.org/keywords/solid-organ-transplant-recipients","display_name":"solid organ transplant recipients","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.765999972820282},{"id":"https://openalex.org/keywords/contact-precautions","display_name":"contact precautions","score":0.5809999704360962},{"id":"https://openalex.org/keywords/respiratory-tract-colonization","display_name":"respiratory tract colonization","score":0.43799999356269836},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.6230000257492065},{"id":"https://openalex.org/keywords/nosocomial-infection-control","display_name":"nosocomial infection prevention","score":0.4699999988079071},{"id":"https://openalex.org/keywords/patient-to-patient-transmission","display_name":"patient-to-patient transmission","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2777756538","wikidata":"https://www.wikidata.org/wiki/Q21401468","display_name":"Burkholderia cepacia complex","level":4,"score":0.8077099323272705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.786250114440918},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.7187042832374573},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6822417974472046},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.5211105942726135},{"id":"https://openalex.org/C122637931","wikidata":"https://www.wikidata.org/wiki/Q118084","display_name":"Unit (ring theory)","level":2,"score":0.4605199098587036},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.44336622953414917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32786035537719727},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2720368206501007},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2720257043838501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21567869186401367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1515520215034485},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1476731300354004},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ofid/ofv133.223","doi":"https://doi.org/10.1093/ofid/ofv133.223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.223","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofv133.223","doi":"https://doi.org/10.1093/ofid/ofv133.223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.223","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409572115","https://openalex.org/W2988471809","https://openalex.org/W3015332475","https://openalex.org/W2004609315","https://openalex.org/W3159185196","https://openalex.org/W4220772113","https://openalex.org/W4283262762","https://openalex.org/W7119476973","https://openalex.org/W2736695098","https://openalex.org/W2220551252"],"abstract_inverted_index":{"Background.":[0],"Burkholderia":[1],"cepacia":[2],"complex":[3],"(BCC)":[4],"has":[5,21],"been":[6,23],"implicated":[7],"in":[8,15,44,104,143,295,343],"nosocomial":[9],"outbreaks":[10],"of":[11,27,36,57,64,79,125,132,179,220,248,270,307,341,350],"respiratory":[12,82,277],"infections":[13],"and":[14,61,68,74,81,98,173,279,314,323],"critically":[16],"ill":[17],"patients.":[18],"Patient-to-patient":[19],"cross-transmission":[20],"also":[22,254],"described.":[24],"The":[25,164,176,216,251],"aim":[26],"this":[28,162],"study":[29],"was":[30,84,120,167,182,189,200,213,223,253,321,332],"to":[31,150,195,208,229,300],"investigate":[32],"a":[33,54,110,123,133,196,209,338],"suspected":[34,55],"outbreak":[35,56,320,331,340],"BCC":[37,58,97,112,140,159,198,211,230,249,271,304,330,342],"carriage":[38],"among":[39],"non-cystic":[40],"fibrosis":[41],"(CF)":[42],"patients":[43,92,145,233],"an":[45,65,344],"intensive":[46,345],"care":[47,346],"unit":[48,353],"(ICU).":[49],"Methods.":[50],"In":[51],"May":[52],"2014":[53],"prompted":[59],"closure":[60],"terminal":[62,76],"cleaning":[63,349],"ICU.":[66],"Environmental":[67],"surveillance":[69,313],"cultures":[70,138,160,309,316],"were":[71,88,114,141,155,171,291],"obtained":[72,310],"before":[73],"after":[75,161],"cleaning.":[77],"Education":[78],"nurses":[80],"therapists":[83],"provided.":[85],"Contact":[86],"precautions":[87],"implemented":[89],"for":[90,139,256,286,328],"all":[91],"colonized":[93],"or":[94],"infected":[95],"with":[96,109,239],"other":[99],"significant":[100],"epidemiologic":[101],"organisms.":[102],"Patients":[103],"the":[105,130,185,203,296,301,319,329,351,355],"ICU":[106,187,205],"\u226548":[107],"hours":[108],"positive":[111,158,197,210,303,308],"culture":[113,199,212],"identified.":[115,333],"Whole":[116],"genome":[117],"sequencing":[118],"(WGS)":[119],"performed":[121],"on":[122,241,292],"subset":[124],"isolates":[126],"that":[127,318],"best":[128],"fit":[129],"criteria":[131,285],"clonal":[134],"outbreak.":[135,356],"Results.":[136],"Positive":[137],"recovered":[142],"28":[144],"from":[146,311],"17":[147],"September":[148],"2013":[149],"30":[151],"June":[152],"2014.":[153],"There":[154],"no":[156,325],"further":[157],"time.":[163],"median":[165,177,186,204],"age":[166],"65":[168,183],"years,":[169],"65%":[170],"male,":[172],"61%":[174],"white.":[175],"length":[178],"stay":[180],"(LOS)":[181],"days;":[184,202],"LOS":[188,193,206],"33":[190],"days.":[191,215],"Median":[192],"prior":[194,207,228,299],"25":[201],"19":[214],"mean":[217],"total":[218,242],"duration":[219],"mechanical":[221],"ventilation":[222],"44":[224],"days":[225,227,247,298],"(28":[226],"infection).":[231],"All":[232,358],"had":[234],">1":[235],"central":[236],"venous":[237],"catheter":[238],"54%":[240],"parenteral":[243],"nutrition":[244],"within":[245,267],"7":[246,297],"infection.":[250,272],"cohort":[252],"notable":[255],"28%":[257],"requiring":[258],"renal":[259],"replacement":[260],"therapy;":[261],"32%":[262],"solid":[263],"organ":[264],"transplant":[265],"recipients":[266],"6":[268],"months":[269],"Culture":[273],"sources":[274],"included":[275],"50%":[276],"tract":[278],"25%":[280],"blood.":[281],"Only":[282],"18%":[283],"met":[284],"ventilator":[287],"associated":[288],"pneumonia.":[289],"71.4%":[290],"systemic":[293],"antibiotics":[294],"first":[302],"culture.":[305],"WGS":[306],"clinical,":[312],"environmental":[315],"showed":[317],"polyclonal":[322],"heterogeneous;":[324],"point":[326],"source":[327],"Conclusion.":[334],"Genomic":[335],"analysis":[336],"demonstrated":[337],"non-clonal":[339],"unit.":[347],"Terminal":[348],"entire":[352],"eradicated":[354],"Disclosures.":[357],"authors:":[359],"No":[360],"reported":[361],"disclosures.":[362]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}
