{"id":"https://openalex.org/W2296971069","doi":"https://doi.org/10.1016/j.jare.2016.03.003","title":"In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride","display_name":"In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride","publication_year":2016,"publication_date":"2016-03-14","ids":{"openalex":"https://openalex.org/W2296971069","doi":"https://doi.org/10.1016/j.jare.2016.03.003","mag":"2296971069","pmid":"https://pubmed.ncbi.nlm.nih.gov/27222750"},"language":"en","primary_location":{"id":"doi:10.1016/j.jare.2016.03.003","doi":"https://doi.org/10.1016/j.jare.2016.03.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2016.03.003","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2090123216300054-fx2_lrg.jpg","source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2090123216300054-fx2_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045715488","display_name":"Iizhar Ahmed Syed","orcid":"https://orcid.org/0000-0002-6823-2356","observed_orcids":["https://orcid.org/0000-0002-6823-2356"]},"institutions":[{"id":"https://openalex.org/I2802668928","display_name":"Ibn Sina National College for Medical Studies","ror":"https://ror.org/0332xca13","country_code":"SA","type":"education","lineage":["https://openalex.org/I2802668928"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Syed Ahmed Iizhar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia","institution_ids":["https://openalex.org/I2802668928"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ismail Ahmed Syed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802668928","display_name":"Ibn Sina National College for Medical Studies","ror":"https://ror.org/0332xca13","country_code":"SA","type":"education","lineage":["https://openalex.org/I2802668928"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ismail Ahmed Syed","raw_affiliation_strings":["Department of Basic Sciences, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia","institution_ids":["https://openalex.org/I2802668928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018061945","display_name":"Rukhsana Satar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802668928","display_name":"Ibn Sina National College for Medical Studies","ror":"https://ror.org/0332xca13","country_code":"SA","type":"education","lineage":["https://openalex.org/I2802668928"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rukhsana Satar","raw_affiliation_strings":["Department of Biochemistry, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Ibn Sina National College of Medical Studies, Jeddah 21418, Saudi Arabia","institution_ids":["https://openalex.org/I2802668928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078255846","display_name":"Shakeel Ahmed Ansari","orcid":"https://orcid.org/0000-0002-5630-8034","observed_orcids":["https://orcid.org/0000-0002-5630-8034"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Shakeel Ahmed Ansari","raw_affiliation_strings":["Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045715488"],"corresponding_institution_ids":["https://openalex.org/I2802668928"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":2.0598,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.83384794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"7","issue":"3","first_page":"453","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethosomes","display_name":"ethosomes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/terbinafine-hydrochloride","display_name":"terbinafine hydrochloride","score":1.0},{"id":"https://openalex.org/keywords/carbopol-934p","display_name":"Carbopol 934P","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ethosomal-gel","display_name":"ethosomal gel","score":0.8690000176429749},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.8370000123977661},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9010000228881836},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.6460000276565552},{"id":"https://openalex.org/keywords/transdermal-flux","display_name":"transdermal flux","score":0.859000027179718},{"id":"https://openalex.org/keywords/vesicle-size","display_name":"vesicle size","score":0.6669999957084656},{"id":"https://openalex.org/keywords/similarity-factor","display_name":"similarity factor","score":0.6179999709129333},{"id":"https://openalex.org/keywords/antifungal-drug-delivery","display_name":"antifungal drug delivery","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2778236110","wikidata":"https://www.wikidata.org/wiki/Q415259","display_name":"Terbinafine","level":4,"score":0.8018717765808105},{"id":"https://openalex.org/C2776460385","wikidata":"https://www.wikidata.org/wiki/Q420060","display_name":"Hydrochloride","level":2,"score":0.559269368648529},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4784150719642639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44411152601242065},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42020687460899353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2084510326385498},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.14097970724105835},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.07468417286872864},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05933535099029541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05202803015708923},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jare.2016.03.003","doi":"https://doi.org/10.1016/j.jare.2016.03.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2016.03.003","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2090123216300054-fx2_lrg.jpg","source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},{"id":"pmid:27222750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27222750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of advanced research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4856831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4856831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Adv Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jare.2016.03.003","doi":"https://doi.org/10.1016/j.jare.2016.03.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2016.03.003","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2090123216300054-fx2_lrg.jpg","source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2296971069.pdf","grobid_xml":"https://content.openalex.org/works/W2296971069.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1839753507","https://openalex.org/W1981423886","https://openalex.org/W1999177915","https://openalex.org/W2002927155","https://openalex.org/W2006496622","https://openalex.org/W2010039501","https://openalex.org/W2014093866","https://openalex.org/W2018867886","https://openalex.org/W2029513013","https://openalex.org/W2033381869","https://openalex.org/W2033930592","https://openalex.org/W2039187196","https://openalex.org/W2068517215","https://openalex.org/W2072446382","https://openalex.org/W2079884183","https://openalex.org/W2089863147","https://openalex.org/W2094151571","https://openalex.org/W2102432127","https://openalex.org/W2126574471","https://openalex.org/W2147234539","https://openalex.org/W2156339880","https://openalex.org/W2182617863","https://openalex.org/W2188767143","https://openalex.org/W2424906403","https://openalex.org/W2746524472"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2470493517"],"abstract_inverted_index":{"The":[0,31,51,79,187],"present":[1],"study":[2,236],"investigates":[3],"the":[4,23,74,159,253],"entrapment":[5,60],"of":[6,49,73,83,139,189,249],"terbinafine":[7],"hydrochloride":[8],"(TH)":[9],"in":[10,22,101,158],"ethosomal":[11,33,133,199],"vesicles":[12,86],"via":[13],"unsonicated":[14],"and":[15,56,64,70,81,155,173,182,197,203,219,229],"sonication":[16,29],"method.":[17,30],"Carbopol":[18],"934P":[19],"was":[20,40,112,117,129,149,178,221],"incorporated":[21],"best":[24],"formulation,":[25],"F6,":[26],"obtained":[27,35],"by":[28,89,114],"formulated":[32],"gel":[34,200],"as":[36],"such":[37],"i.e.":[38],"F6(\u2217)":[39,172,198,209,218,239],"exploited":[41],"to":[42,123,223],"achieve":[43],"a":[44,136,245],"zero":[45],"order":[46],"release":[47,93],"profile":[48],"TH.":[50],"composition":[52],"includes":[53],"phospholipid,":[54],"ethanol":[55],"propylene":[57],"glycol.":[58],"Drug":[59],"efficiency":[61],"(DEE),":[62],"in-vitro":[63],"ex-vivo":[65],"drug":[66,92,110,154,165],"diffusion":[67,166],"studies,":[68],"FT-IR":[69,144],"stability":[71],"studies":[72,94,145],"prepared":[75],"ethosomes":[76,85],"were":[77,87,95,201],"investigated.":[78],"size":[80,138],"shape":[82],"F6":[84,132],"characterized":[88],"SEM.":[90],"In-vitro":[91],"performed":[96],"using":[97],"sigma":[98],"dialysis":[99],"membrane":[100],"phosphate":[102],"buffer,":[103],"pH":[104],"7.4":[105],"for":[106,195,217,244],"12":[107,169],"h":[108,170],"while":[109],"content":[111],"determined":[113],"HPLC.":[115],"DEE":[116,128],"ranked":[118],"from":[119,171],"55.33":[120],"\u00b1":[121,125,141,180,184,226,231],"1.32%":[122],"69.11":[124],"2.11%.":[126],"Highest":[127],"seen":[130],"with":[131,135],"formulation":[134],"vesicle":[137],"248":[140],"1.02":[142],"nm.":[143],"confirmed":[146],"that":[147,164,208,238],"there":[148],"no":[150],"chemical":[151],"interaction":[152],"between":[153],"excipients":[156],"used":[157],"formulation.":[160],"Ex-vivo":[161],"result":[162],"suggested":[163],"observed":[167],"after":[168],"marketed":[174],"cream":[175],"(MR)":[176],"formulations":[177],"74.01":[179],"0.62%":[181],"61.45":[183],"0.86%,":[185],"respectively.":[186,205,234],"results":[188],"similarity":[190],"factor":[191],"(f":[192],"2":[193],"values)":[194],"MR":[196,220],"85.14":[202],"42.63,":[204],"It":[206],"revealed":[207],"showed":[210],"dissimilar":[211],"dissolution":[212],"profiles.":[213],"Transdermal":[214],"flux":[215],"value":[216],"found":[222],"be":[224],"144.61":[225],"1.28":[227],"\u03bcg/cm(2)/h":[228],"121.6":[230],"1.16":[232],"\u03bcg/cm(2)/h,":[233],"This":[235],"disclosed":[237],"resides":[240],"at":[241],"targeted":[242],"site":[243],"relatively":[246],"longer":[247],"period":[248],"time":[250],"thereby":[251],"signifying":[252],"improved":[254],"patient":[255],"compliance.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}