{"id":"https://openalex.org/W2296944404","doi":"https://doi.org/10.1135/css200810071","title":"Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics","display_name":"Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2296944404","doi":"https://doi.org/10.1135/css200810071","mag":"2296944404"},"language":"en","primary_location":{"id":"doi:10.1135/css200810071","doi":"https://doi.org/10.1135/css200810071","is_oa":false,"landing_page_url":"https://doi.org/10.1135/css200810071","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Collection Symposium Series","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100768110","display_name":"Liqiang Chen","orcid":"https://orcid.org/0000-0002-4229-863X","observed_orcids":["https://orcid.org/0000-0002-4229-863X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liqiang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073229561","display_name":"Riccardo Petrelli","orcid":"https://orcid.org/0000-0002-4760-1204","observed_orcids":["https://orcid.org/0000-0002-4760-1204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riccardo Petrelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029050926","display_name":"Krzysztof Felczak","orcid":"https://orcid.org/0000-0002-4207-9429","observed_orcids":["https://orcid.org/0000-0002-4207-9429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof Felczak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067312626","display_name":"Magda Olesiak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magda Olesiak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014410789","display_name":"Eric M. Bennett","orcid":"https://orcid.org/0000-0001-5784-0797","observed_orcids":["https://orcid.org/0000-0001-5784-0797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric M. Bennett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009422066","display_name":"Giulio Magni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulio Magni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013760358","display_name":"Krzysztof W. Pankiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof W. Pankiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22222222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"71","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nad-dependent-enzyme","display_name":"NAD-dependent enzyme","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nad-metabolism","display_name":"NAD+ metabolism","score":0.5759999752044678},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.781000018119812},{"id":"https://openalex.org/keywords/redox-reactions","display_name":"redox reactions","score":0.847000002861023},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.9123684167861938},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.7681742310523987},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6045829057693481},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5414005517959595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47467660903930664},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4445464015007019}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1135/css200810071","doi":"https://doi.org/10.1135/css200810071","is_oa":false,"landing_page_url":"https://doi.org/10.1135/css200810071","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Collection Symposium Series","raw_type":"proceedings-article"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/201480","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11581/201480","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2146163920","https://openalex.org/W2140680416","https://openalex.org/W2300740952","https://openalex.org/W2061659578","https://openalex.org/W3023071112","https://openalex.org/W3033107529","https://openalex.org/W3165517315","https://openalex.org/W2987023548","https://openalex.org/W2099900376","https://openalex.org/W3092621787"],"abstract_inverted_index":{"In":[0],"the":[1,70],"past":[2],"years,":[3],"numerous":[4],"studies":[5],"of":[6,15,27,32,45,54,73],"NAD-dependent":[7,48],"biological":[8],"processes":[9],"have":[10],"revealed":[11],"various":[12],"remarkable":[13],"roles":[14],"NAD":[16,24,46],"in":[17,39],"cell":[18],"biology":[19],"and":[20,29,36],"medicine.":[21],"Enzymes":[22],"utilize":[23],"for":[25],"modification":[26],"DNA":[28],"proteins,":[30],"formation":[31],"signal":[33],"transduction":[34],"agents,":[35],"as":[37],"co-enzymes":[38],"redox":[40],"reactions.":[41],"Molecules":[42],"affecting":[43],"interactions":[44],"with":[47],"or":[49],"NAD-utilizing":[50],"enzymes":[51],"are":[52],"now":[53],"great":[55],"therapeutic":[56],"interest":[57],"ranging":[58],"from":[59],"aging":[60],"to":[61,69],"cancer.":[62],"Herein":[63],"we":[64],"present":[65],"our":[66],"recent":[67],"contribution":[68],"new":[71],"field":[72],"NAD-therapeutics.":[74]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2016-06-24T00:00:00"}