{"id":"https://openalex.org/W2296906677","doi":null,"title":"Better survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptors.","display_name":"Better survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptors.","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2296906677","mag":"2296906677","pmid":"https://pubmed.ncbi.nlm.nih.gov/9260806"},"language":"en","primary_location":{"id":"pmid:9260806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9260806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062743704","display_name":"Irene Oi\u2010Lin Ng","orcid":"https://orcid.org/0000-0001-7532-2029","observed_orcids":["https://orcid.org/0000-0001-7532-2029"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"I O Ng","raw_affiliation_strings":["Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam. iolng@hkusua.hku.hk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam. iolng@hkusua.hku.hk","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111392224","display_name":"Mmt Ng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S T Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0666,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78654971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"92","issue":"8","first_page":"1355","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8330000042915344},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5690000057220459},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/proliferative-cell-nuclear-antigen","display_name":"proliferative cell nuclear antigen","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9269999861717224},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7590000033378601},{"id":"https://openalex.org/keywords/venous-invasion","display_name":"venous invasion","score":0.6060000061988831},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-capsule","display_name":"tumor capsule","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8169553875923157},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.7904623746871948},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6533141732215881},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.561196506023407},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5554957389831543},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5510054230690002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46220138669013977},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4505482316017151},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4441065788269043},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4436432719230652},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.41377323865890503},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4064866900444031},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3912108242511749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34139013290405273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33180147409439087},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32379740476608276},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.231560617685318}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9260806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9260806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/88394","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/88394","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2296906677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9260806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166499689","https://openalex.org/W6884297862","https://openalex.org/W2402115039","https://openalex.org/W84624427","https://openalex.org/W2071647447","https://openalex.org/W4250058977","https://openalex.org/W2016175538","https://openalex.org/W2338645978","https://openalex.org/W2274723254","https://openalex.org/W2604027279"],"abstract_inverted_index":{"OBJECTIVE:":[0],"There":[1],"is":[2,37,54],"a":[3,40],"well":[4],"known":[5],"male":[6,128,210],"predominance":[7],"in":[8,34,92,151,179,215,219,227,256,277],"hepatocellular":[9],"carcinoma":[10],"(HCC).":[11],"Moreover,":[12],"female":[13,35,208],"patients":[14,36,94,116,129],"with":[15,95,101,117,242],"HCC":[16,118,243],"have":[17],"better":[18,32,121,246],"survival":[19,110,125,247,278],"and":[20,46,74,80,85,89,108,123,133,165,189,200,209,223,233,248,260,264,271],"lower":[21,249],"recurrence":[22,251],"rates":[23,111,126],"after":[24],"surgical":[25],"resection.":[26],"We":[27],"previously":[28],"showed":[29],"that":[30,181],"the":[31,51,63,83,102,106,109,216,275],"prognosis":[33],"related":[38],"to":[39,273],"higher":[41,150],"incidence":[42],"of":[43,68,82,105,112,167,221,230,262],"tumor":[44,146,174,191,198,217,250],"encapsulation":[45],"less":[47],"invasive":[48],"tumors.":[49],"However,":[50,196,253],"underlying":[52],"mechanism":[53],"still":[55],"obscure.":[56],"METHODS:":[57],"In":[58],"this":[59],"study,":[60],"we":[61],"examined":[62],"cell":[64,70],"proliferative":[65,69],"indices":[66,259],"(expression":[67],"nuclear":[71],"antigen":[72,76],"(PCNA)":[73],"Ki-67":[75],"using":[77],"MIB1":[78,175,201],"antibody)":[79],"expression":[81,261],"estrogen":[84],"progesterone":[86],"receptors":[87],"(ERs":[88],"PRs,":[90],"respectively)":[91],"71":[93],"resected":[96],"HCC.":[97],"These":[98],"were":[99,148,177,213,225,266],"correlated":[100],"pathological":[103],"features":[104],"tumors":[107,152,180],"patients.":[113,211],"RESULTS:":[114],"Female":[115],"had":[119,182,244],"significantly":[120,149,206,245],"actuarial":[122],"disease-free":[124],"than":[127],"(p":[130,156,162,170,186,193],"=":[131,157,163,171,187,194],"0.010":[132],"0.004,":[134],"respectively).":[135],"Tumor":[136],"PCNA":[137,199],"scores,":[138],"represented":[139],"by":[140,238],"positively":[141],"stained":[142],"nuclei":[143],"per":[144],"1000":[145],"cells,":[147],"showing":[153],"venous":[154],"permeation":[155],"0.034),":[158],"positive":[159],"resection":[160],"margins":[161],"0.011),":[164],"absence":[166],"bile":[168],"production":[169],"0.008).":[172],"Higher":[173],"scores":[176,202],"seen":[178],"poorer":[183],"cellular":[184,257],"differentiation":[185],"0.002)":[188],"no":[190],"capsules":[192],"0.042).":[195],"both":[197,231],"did":[203],"not":[204,236,267],"differ":[205],"between":[207,269],"ERs":[212],"detected":[214,226],"cells":[218],"23.9%":[220],"tumors,":[222],"PRs":[224],"14.3%.":[228],"Expression":[229],"ER":[232,263],"PR":[234,265],"was":[235],"influenced":[237],"gender.":[239],"CONCLUSIONS:":[240],"Women":[241],"rates.":[252],"significant":[254],"differences":[255],"proliferation":[258],"observed":[268],"men":[270],"women":[272],"explain":[274],"difference":[276],"rate.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}