{"id":"https://openalex.org/W229658928","doi":"https://doi.org/10.1007/978-1-4615-3940-7_6","title":"The role of ras gene expression and transforming growth factor \u03b1 production in the etiology and progression of rodent and human breast cancer","display_name":"The role of ras gene expression and transforming growth factor \u03b1 production in the etiology and progression of rodent and human breast cancer","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W229658928","doi":"https://doi.org/10.1007/978-1-4615-3940-7_6","mag":"229658928","pmid":"https://pubmed.ncbi.nlm.nih.gov/1672074"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-3940-7_6","doi":"https://doi.org/10.1007/978-1-4615-3940-7_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-3940-7_6","pdf_url":null,"source":{"id":"https://openalex.org/S2755761368","display_name":"Cancer treatment and research","issn_l":"0927-3042","issn":["0927-3042","2509-8497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2496093664","display_name":"Regulatory Mechanisms in Breast Cancer"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027758178","display_name":"David Salomon","orcid":"https://orcid.org/0000-0002-8327-1927","observed_orcids":["https://orcid.org/0000-0002-8327-1927","https://orcid.org/0000-0003-0939-4344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David S. Salomon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056034569","display_name":"Fortunato Ciardiello","orcid":"https://orcid.org/0000-0002-3369-4841","observed_orcids":["https://orcid.org/0000-0002-3369-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fortunato Ciardiello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018398653","display_name":"Eva M. Valverius","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva M. Valverius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053294959","display_name":"Nancy Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7907,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.7556205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":null,"first_page":"107","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9890000224113464},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/proto-oncogenes","display_name":"proto-oncogenes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.925000011920929},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.640999972820282},{"id":"https://openalex.org/keywords/oncogene-activation","display_name":"oncogene activation","score":0.4580000042915344},{"id":"https://openalex.org/keywords/retinoblastoma-gene","display_name":"retinoblastoma gene","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7570335268974304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6015133261680603},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5440870523452759},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.5335769057273865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46165311336517334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44785502552986145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41021695733070374},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4100790023803711}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4615-3940-7_6","doi":"https://doi.org/10.1007/978-1-4615-3940-7_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-3940-7_6","pdf_url":null,"source":{"id":"https://openalex.org/S2755761368","display_name":"Cancer treatment and research","issn_l":"0927-3042","issn":["0927-3042","2509-8497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research","raw_type":"book-chapter"},{"id":"pmid:1672074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1672074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment and research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":284,"referenced_works":["https://openalex.org/W19368617","https://openalex.org/W34093332","https://openalex.org/W35268600","https://openalex.org/W44741267","https://openalex.org/W49938305","https://openalex.org/W62063735","https://openalex.org/W99546337","https://openalex.org/W106933811","https://openalex.org/W140881210","https://openalex.org/W151446319","https://openalex.org/W175457669","https://openalex.org/W254776376","https://openalex.org/W327621524","https://openalex.org/W397853713","https://openalex.org/W562449587","https://openalex.org/W628785963","https://openalex.org/W1233602357","https://openalex.org/W1422466461","https://openalex.org/W1493551679","https://openalex.org/W1495388995","https://openalex.org/W1503388237","https://openalex.org/W1504343794","https://openalex.org/W1508300148","https://openalex.org/W1508929596","https://openalex.org/W1521102442","https://openalex.org/W1535473141","https://openalex.org/W1538717037","https://openalex.org/W1542358602","https://openalex.org/W1545662949","https://openalex.org/W1551168702","https://openalex.org/W1552433070","https://openalex.org/W1568217878","https://openalex.org/W1576066788","https://openalex.org/W1576294590","https://openalex.org/W1584352278","https://openalex.org/W1589525182","https://openalex.org/W1590250543","https://openalex.org/W1603499703","https://openalex.org/W1606224998","https://openalex.org/W1616273863","https://openalex.org/W1627068912","https://openalex.org/W1639892513","https://openalex.org/W1640301613","https://openalex.org/W1672503434","https://openalex.org/W1767075578","https://openalex.org/W1811411196","https://openalex.org/W1819831344","https://openalex.org/W1841053541","https://openalex.org/W1847098517","https://openalex.org/W1867003241","https://openalex.org/W1878138973","https://openalex.org/W1880370648","https://openalex.org/W1891687116","https://openalex.org/W1904731887","https://openalex.org/W1906149319","https://openalex.org/W1932528123","https://openalex.org/W1932867946","https://openalex.org/W1933402656","https://openalex.org/W1933454536","https://openalex.org/W1935820490","https://openalex.org/W1942629554","https://openalex.org/W1963930657","https://openalex.org/W1963965510","https://openalex.org/W1964490749","https://openalex.org/W1964718153","https://openalex.org/W1966523330","https://openalex.org/W1966683022","https://openalex.org/W1966867506","https://openalex.org/W1966895290","https://openalex.org/W1967229406","https://openalex.org/W1967850071","https://openalex.org/W1969006090","https://openalex.org/W1970516412","https://openalex.org/W1970626129","https://openalex.org/W1970852573","https://openalex.org/W1970866978","https://openalex.org/W1970995282","https://openalex.org/W1971527300","https://openalex.org/W1973491865","https://openalex.org/W1973677994","https://openalex.org/W1974393133","https://openalex.org/W1975729483","https://openalex.org/W1975797622","https://openalex.org/W1977797997","https://openalex.org/W1978109296","https://openalex.org/W1979529419","https://openalex.org/W1981646920","https://openalex.org/W1983596426","https://openalex.org/W1986383101","https://openalex.org/W1986567580","https://openalex.org/W1987108079","https://openalex.org/W1988761203","https://openalex.org/W1988925715","https://openalex.org/W1990030781","https://openalex.org/W1994849663","https://openalex.org/W1995746818","https://openalex.org/W1996053339","https://openalex.org/W1996830465","https://openalex.org/W1997643297","https://openalex.org/W1997855715","https://openalex.org/W1998080624","https://openalex.org/W1998954931","https://openalex.org/W1999838666","https://openalex.org/W2000581372","https://openalex.org/W2002263141","https://openalex.org/W2005764975","https://openalex.org/W2007183039","https://openalex.org/W2007523206","https://openalex.org/W2008569839","https://openalex.org/W2009496517","https://openalex.org/W2009886925","https://openalex.org/W2010178768","https://openalex.org/W2011403484","https://openalex.org/W2011758204","https://openalex.org/W2012383791","https://openalex.org/W2012806962","https://openalex.org/W2012850212","https://openalex.org/W2014274829","https://openalex.org/W2014724176","https://openalex.org/W2015217365","https://openalex.org/W2015782045","https://openalex.org/W2015825004","https://openalex.org/W2016142807","https://openalex.org/W2017095060","https://openalex.org/W2019691808","https://openalex.org/W2020283335","https://openalex.org/W2020333197","https://openalex.org/W2020590765","https://openalex.org/W2022206818","https://openalex.org/W2023023900","https://openalex.org/W2023150384","https://openalex.org/W2023983577","https://openalex.org/W2024247791","https://openalex.org/W2024507604","https://openalex.org/W2025195066","https://openalex.org/W2025287691","https://openalex.org/W2026578950","https://openalex.org/W2026989222","https://openalex.org/W2028474574","https://openalex.org/W2028772967","https://openalex.org/W2030450565","https://openalex.org/W2032525309","https://openalex.org/W2032923234","https://openalex.org/W2033436103","https://openalex.org/W2033461320","https://openalex.org/W2034185792","https://openalex.org/W2035208645","https://openalex.org/W2035244457","https://openalex.org/W2036033314","https://openalex.org/W2036744157","https://openalex.org/W2037312854","https://openalex.org/W2037871888","https://openalex.org/W2038445681","https://openalex.org/W2038861485","https://openalex.org/W2038942405","https://openalex.org/W2039916012","https://openalex.org/W2040245644","https://openalex.org/W2040838664","https://openalex.org/W2040976289","https://openalex.org/W2041354540","https://openalex.org/W2042398627","https://openalex.org/W2042917826","https://openalex.org/W2043905687","https://openalex.org/W2044014221","https://openalex.org/W2045372146","https://openalex.org/W2045956897","https://openalex.org/W2046733107","https://openalex.org/W2046756969","https://openalex.org/W2050114795","https://openalex.org/W2052525987","https://openalex.org/W2052878543","https://openalex.org/W2052977964","https://openalex.org/W2054012934","https://openalex.org/W2054904912","https://openalex.org/W2055870203","https://openalex.org/W2057094603","https://openalex.org/W2057409901","https://openalex.org/W2057729296","https://openalex.org/W2058232950","https://openalex.org/W2058333572","https://openalex.org/W2059048157","https://openalex.org/W2061215313","https://openalex.org/W2063559195","https://openalex.org/W2063837791","https://openalex.org/W2065418754","https://openalex.org/W2065951262","https://openalex.org/W2066960327","https://openalex.org/W2071078274","https://openalex.org/W2071697240","https://openalex.org/W2072581924","https://openalex.org/W2073944052","https://openalex.org/W2074568047","https://openalex.org/W2074951828","https://openalex.org/W2077689919","https://openalex.org/W2079816467","https://openalex.org/W2080155377","https://openalex.org/W2080910520","https://openalex.org/W2081335151","https://openalex.org/W2082315237","https://openalex.org/W2085435345","https://openalex.org/W2086013495","https://openalex.org/W2086322317","https://openalex.org/W2086944332","https://openalex.org/W2087082455","https://openalex.org/W2087884848","https://openalex.org/W2091984663","https://openalex.org/W2092474335","https://openalex.org/W2092818994","https://openalex.org/W2094267240","https://openalex.org/W2094401887","https://openalex.org/W2094915902","https://openalex.org/W2096203950","https://openalex.org/W2097177203","https://openalex.org/W2097694896","https://openalex.org/W2099357201","https://openalex.org/W2102957784","https://openalex.org/W2103885797","https://openalex.org/W2105663297","https://openalex.org/W2106480106","https://openalex.org/W2113210366","https://openalex.org/W2117431926","https://openalex.org/W2122318037","https://openalex.org/W2126486896","https://openalex.org/W2127207727","https://openalex.org/W2132474852","https://openalex.org/W2133133102","https://openalex.org/W2135029178","https://openalex.org/W2139401320","https://openalex.org/W2141393790","https://openalex.org/W2142360480","https://openalex.org/W2143598251","https://openalex.org/W2149051154","https://openalex.org/W2150268629","https://openalex.org/W2153645580","https://openalex.org/W2153837633","https://openalex.org/W2155009866","https://openalex.org/W2155011423","https://openalex.org/W2155958456","https://openalex.org/W2156872475","https://openalex.org/W2158593262","https://openalex.org/W2160984505","https://openalex.org/W2163488649","https://openalex.org/W2164034599","https://openalex.org/W2165141978","https://openalex.org/W2165446716","https://openalex.org/W2166095082","https://openalex.org/W2167591082","https://openalex.org/W2170264926","https://openalex.org/W2255395527","https://openalex.org/W2274694799","https://openalex.org/W2275949493","https://openalex.org/W2284540638","https://openalex.org/W2337090809","https://openalex.org/W2378836122","https://openalex.org/W2380367794","https://openalex.org/W2396242123","https://openalex.org/W2398255640","https://openalex.org/W2400589564","https://openalex.org/W2401800080","https://openalex.org/W2405091638","https://openalex.org/W2409363475","https://openalex.org/W2409509985","https://openalex.org/W2414647879","https://openalex.org/W2416113306","https://openalex.org/W2416746204","https://openalex.org/W2417216647","https://openalex.org/W2418290103","https://openalex.org/W2419655347","https://openalex.org/W2419977998","https://openalex.org/W2422687558","https://openalex.org/W2425302584","https://openalex.org/W2465365546","https://openalex.org/W2609793932","https://openalex.org/W2622028798","https://openalex.org/W2895451238","https://openalex.org/W2988090440","https://openalex.org/W3022691628","https://openalex.org/W4232777855","https://openalex.org/W4239349584","https://openalex.org/W4251864676","https://openalex.org/W4255042798","https://openalex.org/W6681386731","https://openalex.org/W6738900538","https://openalex.org/W6829521910"],"related_works":["https://openalex.org/W7217778195","https://openalex.org/W956831362","https://openalex.org/W2090870107","https://openalex.org/W7096199692","https://openalex.org/W2263780001","https://openalex.org/W7098621596","https://openalex.org/W2409509985","https://openalex.org/W2246728392","https://openalex.org/W55809","https://openalex.org/W25550095"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}