{"id":"https://openalex.org/W2296550596","doi":"https://doi.org/10.1371/journal.pone.0148373","title":"Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health)","display_name":"Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health)","publication_year":2016,"publication_date":"2016-03-03","ids":{"openalex":"https://openalex.org/W2296550596","doi":"https://doi.org/10.1371/journal.pone.0148373","mag":"2296550596","pmid":"https://pubmed.ncbi.nlm.nih.gov/26938215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4777542"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0148373","doi":"https://doi.org/10.1371/journal.pone.0148373","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0148373","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0148373&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0148373&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049759076","display_name":"Brett C. Haberstick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brett C. Haberstick","raw_affiliation_strings":["Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jason D. Boardman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Boardman","raw_affiliation_strings":["Institute of Behavioral Science, University of Colorado at Boulder, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Behavioral Science, University of Colorado at Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053719219","display_name":"Brandon Wagner","orcid":"https://orcid.org/0000-0002-1023-4762","observed_orcids":["https://orcid.org/0000-0002-1023-4762"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Wagner","raw_affiliation_strings":["Department of Sociology, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sociology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085447170","display_name":"Andrew Smolen","orcid":"https://orcid.org/0000-0002-9030-0562","observed_orcids":["https://orcid.org/0000-0002-9030-0562"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Smolen","raw_affiliation_strings":["Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017046391","display_name":"John K. Hewitt","orcid":"https://orcid.org/0000-0001-9415-2723","observed_orcids":["https://orcid.org/0000-0001-9415-2723"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John K. Hewitt","raw_affiliation_strings":["Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046163206","display_name":"Ley A. Killeya\u2010Jones","orcid":"https://orcid.org/0000-0003-1315-663X","observed_orcids":["https://orcid.org/0000-0003-1315-663X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ley A. Killeya-Jones","raw_affiliation_strings":["Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091767283","display_name":"Joyce W. Tabor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Tabor","raw_affiliation_strings":["Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033673736","display_name":"Carolyn Tucker Halpern","orcid":"https://orcid.org/0000-0003-4278-5646","observed_orcids":["https://orcid.org/0000-0003-4278-5646"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn T. Halpern","raw_affiliation_strings":["Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046272563","display_name":"Beverly H. Brummett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly H. Brummett","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050340550","display_name":"Redford B. Williams","orcid":"https://orcid.org/0000-0002-8581-0648","observed_orcids":["https://orcid.org/0000-0002-8581-0648"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Redford B. Williams","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024683409","display_name":"Ilene C. Siegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilene C. Siegler","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091070121","display_name":"Christian Jean Hopfer","orcid":"https://orcid.org/0000-0003-3085-3509","observed_orcids":["https://orcid.org/0000-0003-3085-3509"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian J. Hopfer","raw_affiliation_strings":["Department of Psychiatry, Health Sciences Center, University of Colorado, Denver, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Health Sciences Center, University of Colorado, Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037541907","display_name":"Kathleen Mullan Harris","orcid":"https://orcid.org/0000-0001-9757-1026","observed_orcids":["https://orcid.org/0000-0001-9757-1026"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Mullan Harris","raw_affiliation_strings":["Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","Department of Sociology, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Sociology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049759076"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.7635,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.82096334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"e0148373","last_page":"e0148373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6779999732971191},{"id":"https://openalex.org/keywords/stressful-life-events","display_name":"life events","score":0.9869999885559082},{"id":"https://openalex.org/keywords/serotonin-transporter-gene","display_name":"serotonin transporter gene","score":0.7990000247955322},{"id":"https://openalex.org/keywords/5-httlpr-polymorphism","display_name":"5-HTTLPR polymorphism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/young-adulthood","display_name":"early adulthood","score":0.49900001287460327},{"id":"https://openalex.org/keywords/suicidal-ideation","display_name":"suicidal ideation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/child-abuse","display_name":"child abuse","score":0.9290000200271606},{"id":"https://openalex.org/keywords/replication","display_name":"replication","score":0.4950000047683716},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.7132718563079834},{"id":"https://openalex.org/C2776641880","wikidata":"https://www.wikidata.org/wiki/Q944142","display_name":"Suicidal ideation","level":4,"score":0.6139309406280518},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.590103030204773},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5207529067993164},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5067029595375061},{"id":"https://openalex.org/C526869908","wikidata":"https://www.wikidata.org/wiki/Q3298118","display_name":"Suicide prevention","level":3,"score":0.4753379821777344},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.47466304898262024},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.45527926087379456},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.44166454672813416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4277445077896118},{"id":"https://openalex.org/C187155963","wikidata":"https://www.wikidata.org/wiki/Q629029","display_name":"Occupational safety and health","level":2,"score":0.41960498690605164},{"id":"https://openalex.org/C2780176501","wikidata":"https://www.wikidata.org/wiki/Q5690755","display_name":"Health and Retirement Study","level":2,"score":0.4167746305465698},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.40668410062789917},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3400503993034363},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.29428765177726746},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.17688018083572388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13090163469314575},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1199689507484436},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002649","descriptor_name":"Child Abuse","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008016","descriptor_name":"Life Change Events","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059020","descriptor_name":"Suicidal Ideation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pone.0148373","doi":"https://doi.org/10.1371/journal.pone.0148373","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0148373","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0148373&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3758526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4777542","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4777542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4777542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26938215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26938215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:cuscholar:d217qq202","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/concern/articles/d217qq202","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:scholar.colorado.edu:socy_facpapers-1003","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/socy_facpapers/1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sociology Faculty Contributions","raw_type":"text"},{"id":"pmh:cdr.lib.unc.edu:xs55mj15r","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/wev7-2437","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS One, 11(3)","raw_type":"Article"},{"id":"pmh:oai:RePEc:plo:pone00:0148373","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148373","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:08d50d467cf94ab5ab1d49e7cab64b01","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08d50d467cf94ab5ab1d49e7cab64b01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 3, p e0148373 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3098263","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Depression_Stressful_Life_Events_and_the_Impact_of_Variation_in_the_Serotonin_Transporter_Findings_from_the_National_Longitudinal_Study_of_Adolescent_to_Adult_Health_Add_Health_/3098263","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.17615/wev7-2437","doi":"https://doi.org/10.17615/wev7-2437","is_oa":true,"landing_page_url":"https://doi.org/10.17615/wev7-2437","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0148373","doi":"https://doi.org/10.1371/journal.pone.0148373","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0148373","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0148373&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G243404832","display_name":"University of Colorado Population Center","funder_award_id":"P2CHD066613","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G385978078","display_name":"Genes, environmental stressors, and the biobehavioral pathways to CVD","funder_award_id":"P01HL036587","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G422804853","display_name":"The National Longitudinal Study of Adolescent  to Adult Health","funder_award_id":"P01HD031921","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4441724930","display_name":"Genetics and Progression of Early-onset Substance Dependence and HIV Risk","funder_award_id":"R01DA035804","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G597551293","display_name":null,"funder_award_id":"P01\u2010HD31921","funder_id":"https://openalex.org/F4320332600","funder_display_name":"University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G6042139217","display_name":"Colorado Adoption Project/Twin Study of Lifespan behavioral development & cognitive aging [CATSLife2]","funder_award_id":"R01AG046938","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7144456175","display_name":"Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research","funder_award_id":"K24DA032555","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7282723123","display_name":"Carolina Population Center","funder_award_id":"P2CHD050924","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332524","display_name":"Gillings School of Public Health","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2296550596.pdf","grobid_xml":"https://content.openalex.org/works/W2296550596.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1480729244","https://openalex.org/W1966372902","https://openalex.org/W1975659411","https://openalex.org/W1977826758","https://openalex.org/W1980353834","https://openalex.org/W1984230889","https://openalex.org/W1989784453","https://openalex.org/W2005534453","https://openalex.org/W2014756343","https://openalex.org/W2021622240","https://openalex.org/W2023288605","https://openalex.org/W2028197440","https://openalex.org/W2034004647","https://openalex.org/W2034325147","https://openalex.org/W2034392226","https://openalex.org/W2040422645","https://openalex.org/W2042059267","https://openalex.org/W2042170262","https://openalex.org/W2042282961","https://openalex.org/W2053127039","https://openalex.org/W2054931962","https://openalex.org/W2057860544","https://openalex.org/W2062418646","https://openalex.org/W2063661333","https://openalex.org/W2070814511","https://openalex.org/W2080229119","https://openalex.org/W2081971101","https://openalex.org/W2087414280","https://openalex.org/W2087691806","https://openalex.org/W2095271108","https://openalex.org/W2097280669","https://openalex.org/W2099365033","https://openalex.org/W2100230238","https://openalex.org/W2100510779","https://openalex.org/W2101544610","https://openalex.org/W2106095564","https://openalex.org/W2106888773","https://openalex.org/W2112778345","https://openalex.org/W2122246853","https://openalex.org/W2123722790","https://openalex.org/W2124169870","https://openalex.org/W2124215538","https://openalex.org/W2124342855","https://openalex.org/W2127722821","https://openalex.org/W2138962612","https://openalex.org/W2147985921","https://openalex.org/W2148368421","https://openalex.org/W2151135161","https://openalex.org/W2162196924","https://openalex.org/W2168088534","https://openalex.org/W2174681609","https://openalex.org/W4248629646"],"related_works":["https://openalex.org/W2145430042","https://openalex.org/W2017108245","https://openalex.org/W1992022037","https://openalex.org/W1983620302","https://openalex.org/W2106888773","https://openalex.org/W2072122864","https://openalex.org/W2109026965","https://openalex.org/W1977826758","https://openalex.org/W2042059267","https://openalex.org/W2042170262"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"low":[2],"transcriptionally":[3],"efficient":[4],"short-allele":[5],"of":[6,22,54,67,95,99,141,166,182,202,209,237],"the":[7,17,20,52,63,100,128,164,192,200,207,228,235,240],"5HTTLPR":[8,169,241],"serotonin":[9],"transporter":[10],"polymorphism":[11],"has":[12],"been":[13],"implicated":[14],"to":[15,69,105,150],"moderate":[16],"relationship":[18,43,120],"between":[19,51],"experience":[21,201],"stressful":[23,203],"life":[24,204],"events":[25,205],"(SLEs)":[26],"and":[27,49,56,84,112,168,176,220,250],"depression.":[28,118],"Despite":[29],"numerous":[30],"attempts":[31],"at":[32,113],"replicating":[33],"this":[34,42,217],"observation,":[35],"results":[36,187,229],"remain":[37],"inconclusive.":[38],"METHODS:":[39],"We":[40],"examined":[41],"in":[44,62,122,206,242],"young-adult":[45],"Non-Hispanic":[46],"white":[47],"males":[48,175],"females":[50],"ages":[53],"22":[55],"26":[57],"(n":[58],"=":[59],"4724)":[60],"participating":[61],"National":[64],"Longitudinal":[65],"Study":[66],"Adolescent":[68],"Adult":[70],"Health":[71],"(Add":[72],"Health)":[73],"with":[74,109,199,216,247],"follow-up":[75],"information":[76],"every":[77],"six":[78],"years":[79],"since":[80],"1995.":[81],"RESULTS:":[82],"Linear":[83],"logistic":[85],"regression":[86],"models,":[87],"corrected":[88],"for":[89,117,130,155,174,191],"multiple":[90],"testing,":[91],"indicated":[92],"that":[93,127,163,195],"carriers":[94],"one":[96],"or":[97],"more":[98,103],"S-alleles":[101],"were":[102,147,179,230],"sensitive":[104],"stress":[106],"than":[107],"those":[108,135],"two":[110],"L-alleles":[111],"a":[114,123,221,224],"higher":[115,139],"risk":[116,129],"This":[119],"behaved":[121],"dose-response":[124],"manner":[125],"such":[126],"depression":[131,210,251],"was":[132],"greatest":[133],"among":[134],"who":[136],"reported":[137],"experiencing":[138],"numbers":[140],"SLEs.":[142],"In":[143],"post-hoc":[144],"analyses":[145],"we":[146],"not":[148,232],"able":[149],"replicate":[151],"an":[152],"interaction":[153],"effect":[154],"suicide":[156,171],"ideation":[157,172],"but":[158],"did":[159],"find":[160],"suggestive":[161],"evidence":[162],"effects":[165,181],"SLEs":[167],"on":[170],"differed":[173],"females.":[177],"There":[178],"no":[180],"childhood":[183],"maltreatment.":[184],"DISCUSSION:":[185],"Our":[186],"provide":[188],"partial":[189],"support":[190],"original":[193],"hypothesis":[194],"5-HTTLPR":[196],"genotype":[197],"interacts":[198],"etiology":[208],"during":[211],"young":[212],"adulthood.":[213],"However,":[214],"even":[215],"large":[218,244],"sample,":[219],"carefully":[222],"constructed":[223],"priori":[225],"analysis":[226],"plan,":[227],"still":[231],"definitive.":[233],"For":[234],"purposes":[236],"replication,":[238],"characterizing":[239],"other":[243],"data":[245],"sets":[246],"extensive":[248],"environmental":[249],"measures":[252],"is":[253],"needed.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
