{"id":"https://openalex.org/W2296413699","doi":"https://doi.org/10.1056/nejm198605293142214","title":"AIDS, Blood Transfusions, and Directed Donations","display_name":"AIDS, Blood Transfusions, and Directed Donations","publication_year":1986,"publication_date":"1986-05-29","ids":{"openalex":"https://openalex.org/W2296413699","doi":"https://doi.org/10.1056/nejm198605293142214","mag":"2296413699","pmid":"https://pubmed.ncbi.nlm.nih.gov/3010115"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198605293142214","doi":"https://doi.org/10.1056/nejm198605293142214","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198605293142214","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110530610","display_name":"Thomas F. Zuck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T F Zuck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088525133","display_name":"M S Preston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Preston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218947","display_name":"Donald L. Tankersley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Tankersley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017440368","display_name":"Martha A. Wells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Wells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111916691","display_name":"Alec E. Wittek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Wittek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141450144","display_name":"J E Epstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Epstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141461068","display_name":"S Daniel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Daniel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141798207","display_name":"M Phelan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Phelan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109316144","display_name":"Quinnan Gv","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G V Quinnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.6311,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.98108747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"314","issue":"22","first_page":"1454","last_page":"1454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.12280000001192093,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-iii","display_name":"HTLV-III","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/virus-inactivation","display_name":"virus inactivation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/transfusion-safety","display_name":"transfusion safety","score":0.718999981880188},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.4480000138282776},{"id":"https://openalex.org/keywords/transfusion-transmitted-infections","display_name":"transfusion-transmitted infections","score":0.5249999761581421},{"id":"https://openalex.org/keywords/virus-removal-efficiency","display_name":"virus removal efficiency","score":0.44200000166893005},{"id":"https://openalex.org/keywords/passive-antibody-transfer","display_name":"passive antibody transfer","score":0.5479999780654907},{"id":"https://openalex.org/keywords/immunocompromised-recipients","display_name":"immunocompromised recipients","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9155055284500122},{"id":"https://openalex.org/C2908668021","wikidata":"https://www.wikidata.org/wiki/Q53467","display_name":"Blood donations","level":3,"score":0.5986893773078918},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.5212265253067017},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.45115339756011963},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4436703324317932},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2642322778701782},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005591","descriptor_name":"Chemical Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017977","descriptor_name":"Deltaretrovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejm198605293142214","doi":"https://doi.org/10.1056/nejm198605293142214","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198605293142214","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:3010115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3010115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Letter"},{"id":"pmid:3702957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3702957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Letter"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/813813","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/813813","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:66483","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1991182388","https://openalex.org/W2078622145","https://openalex.org/W2418176671"],"related_works":["https://openalex.org/W2090113589","https://openalex.org/W1991182388","https://openalex.org/W2271239001","https://openalex.org/W4298544944","https://openalex.org/W2508807353","https://openalex.org/W2068634493","https://openalex.org/W2009278263","https://openalex.org/W2034087006","https://openalex.org/W2030170062","https://openalex.org/W2019362284"],"abstract_inverted_index":{"Prince":[0,197,235],"et":[1,198,236],"al.":[2,199,237],"(Feb.":[3],"6":[4],"issue)":[5],"recently":[6,55],"expressed":[7],"concern":[8],"that":[9,28,101,179,200,427],"human":[10],"T-cell":[11],"lymphotropic":[12],"virus":[13,151,178],"Type":[14],"III":[15,127],"(HTLV-III)":[16],"could":[17,181,305],"be":[18,170,182,262],"transmitted":[19],"by":[20,84,91,234,335,340,383,393],"intravenous":[21,217,230,331],"immune":[22,135,189,203,231,277,287,319,332,420,430],"globulin":[23,190,204,232,278,288,333,421,431],"preparations.":[24],"They":[26],"suggested":[27,233],"conditions":[29],"used":[30,187],"to":[31,172,264,283,380],"make":[32],"intermediate":[33],"Cohn-Oncley":[34,69,112],"fractions":[35,70],"did":[36,43],"not":[37,44,210,215,261,433],"inactivate":[38],"spiked":[39,65],"HTLV-III;":[40],"however":[41],"they":[42,222,269],"study":[45],"partitioning":[46,73,142],"of":[47,59,134,141,150,153,165,177,196,202,227,229,245,250,330,364,385,390,410,413,419,429,438,441],"HTLV-III":[48,63,102,120,207,284,404],"into":[49,66,125],"the":[50,57,67,111,116,132,174,194,243,408,414,436,439],"various":[51,68,336],"fractions.":[52],"We":[54],"reported":[56],"results":[58,409],"such":[60,303],"studies.":[61],"was":[64,82,103,121],"and":[71,76,87,105,143,259,371,387,417],"its":[72],"between":[74],"precipitates":[75],"supernatants":[77],"as":[78,80,221],"well":[79],"inactivation":[81,144],"studied":[83],"viral":[85],"cultures":[86],"quantitative":[88],"antigen":[89],"measurements":[90],"antigen-capture":[92],"enzyme-linked":[93],"immunosorbent":[94],"assay":[95],"(ELISA).":[96],"These":[98],"studies":[99,226,412],"showed":[100],"partioned":[104],"inactivated":[106],"at":[107],"multiple":[108],"steps":[109],"in":[110,146,184,299],"process.":[113],"At":[115],"most":[117,255],"efficient":[118],"step":[119],"quantitatively":[122],"(99.5%)":[123],"partitioned":[124],"precipitate":[126],"a":[128,147,290,322],"fraction":[129],"discarded":[130],"during":[131],"manufacturer":[133],"globulin.":[136],"The":[138,248,344,350,360,365],"cumulative":[139],"effects":[140],"resulted":[145],"potential":[148],"efficiency":[149,161],"removal":[152],"10(15)":[154],"infectious":[155],"units":[156],"per":[157],"milliliter.":[158],"This":[160],"is":[162,209,252,432],"many":[163],"orders":[164],"magnitude":[166],"greater":[167],"than":[168],"would":[169,205,260],"needed":[171],"eliminate":[173],"small":[175],"amounts":[176],"potentially":[180],"present":[183],"plasma":[185],"pools":[186],"for":[188,295,378],"manufacture.":[191],"Thus":[193,407],"conjecture":[195],"lyophilization":[201],"preserve":[206],"infectivity":[208],"relevant.":[211],"In":[213],"addition":[214],"all":[216],"preparations":[218,279],"are":[219,257,293],"lyophilized":[220],"implied.":[223],"Surveillance":[225],"recipients":[228,256,315,422],"have":[238,306,375],"been":[239,307,376],"under":[240],"way":[241],"since":[242],"autumn":[244],"1985.":[246],"number":[249],"patients":[251,285,304,317,397],"limited":[253],"because":[254,276],"immunodeficient":[258],"expected":[263],"acquire":[265],"antibodies":[266,282],"even":[267],"if":[268],"were":[270],"infected":[271],"with":[272,318,324,435],"HTLV-III.":[273],"Furthermore":[275],"may":[280],"contain":[281],"receiving":[286],"on":[289],"long-term":[291],"basis":[292],"unsuitable":[294],"study;":[296],"antibody":[297],"detected":[298],"serum":[300,391],"samples":[301],"from":[302],"transferred":[308,400],"passively.":[309],"Despite":[311],"these":[312],"limitations":[313],"134":[314],"(mostly":[316],"thrombocytopenia":[320],"but":[321],"few":[323],"renal":[325],"transplants":[326],"or":[327],"Kawasakis":[328],"disease)":[329],"made":[334],"manufacturers":[337],"(data":[338],"provided":[339],"J.":[341],"Bussel":[342],"M.D.":[343],"New":[345],"York":[346],"Hospital-Cornell":[347],"Medical":[348],"Center":[349],"Massachusetts":[351],"Public":[352],"Health":[353],"Biologic":[354],"Laboratories":[355,357,359],"Miles":[356],"Travenol":[358],"Blood":[361],"Transfusion":[362],"Service":[363],"Swiss":[366],"Red":[367],"Cross":[368],"Immuno":[369],"AG":[370],"Kabi":[372],"Vitrum":[373],"AB)":[374],"followed":[377],"2":[379],"24":[381],"months":[382],"means":[384],"ELISA":[386],"Western":[388],"blotting":[389],"reactive":[392],"ELISA.":[394],"3":[396],"had":[398],"passively":[399],"antibodies;":[401],"none":[402],"produced":[403],"antibodies.":[405],"laboratory":[411],"fractionation":[415],"process":[416],"surveillance":[418],"corroborate":[423],"epidemiologic":[424],"observations":[425],"indicating":[426],"receipt":[428],"associated":[434],"risk":[437],"development":[440],"AIDS.":[442],"(full":[444],"text)":[445]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
