{"id":"https://openalex.org/W22961015","doi":"https://doi.org/10.1016/s0021-9258(18)68274-2","title":"Rapid reaction studies on the reduction and oxidation of chicken liver xanthine dehydrogenase by the xanthine/urate and NAD/NADH couples.","display_name":"Rapid reaction studies on the reduction and oxidation of chicken liver xanthine dehydrogenase by the xanthine/urate and NAD/NADH couples.","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W22961015","doi":"https://doi.org/10.1016/s0021-9258(18)68274-2","mag":"22961015","pmid":"https://pubmed.ncbi.nlm.nih.gov/3166459"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)68274-2","doi":"https://doi.org/10.1016/s0021-9258(18)68274-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)68274-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)68274-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085576102","display_name":"Lawrence M. Schopfer","orcid":"https://orcid.org/0000-0002-1785-9247","observed_orcids":["https://orcid.org/0000-0002-1785-9247"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Schopfer","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079221179","display_name":"Vincent Massey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Massey","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112054323","display_name":"T Nishino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Nishino","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.318,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.79648368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"263","issue":"27","first_page":"13528","last_page":"13538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.350600004196167,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-dehydrogenase","display_name":"xanthine dehydrogenase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chicken-liver","display_name":"chicken liver","score":0.8289999961853027},{"id":"https://openalex.org/keywords/enzymatic-reduction","display_name":"enzymatic reduction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/enzymatic-oxidation","display_name":"enzymatic oxidation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/xanthine","display_name":"xanthine","score":0.7609999775886536},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nicotinamide-adenine-dinucleotide","display_name":"NAD+","score":0.8999999761581421},{"id":"https://openalex.org/keywords/redox-couples","display_name":"redox couples","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C151400659","wikidata":"https://www.wikidata.org/wiki/Q15330855","display_name":"Xanthine dehydrogenase","level":4,"score":0.8785898685455322},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.7898121476173401},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.7607017159461975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6515982151031494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5929182171821594},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5448735356330872},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.43053942918777466},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3756389319896698},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.31427842378616333}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004227","descriptor_name":"Dithionite","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007658","descriptor_name":"Ketone Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014968","descriptor_name":"Xanthine Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019820","descriptor_name":"Xanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)68274-2","doi":"https://doi.org/10.1016/s0021-9258(18)68274-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)68274-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:3166459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3166459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)68274-2","doi":"https://doi.org/10.1016/s0021-9258(18)68274-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)68274-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W8223005","https://openalex.org/W50126086","https://openalex.org/W87354709","https://openalex.org/W1488225405","https://openalex.org/W1489176760","https://openalex.org/W1500658881","https://openalex.org/W1506081958","https://openalex.org/W1513416677","https://openalex.org/W1516424539","https://openalex.org/W1522757325","https://openalex.org/W1563049574","https://openalex.org/W1564950588","https://openalex.org/W1566291916","https://openalex.org/W1573201350","https://openalex.org/W1589976215","https://openalex.org/W1596603243","https://openalex.org/W1598834574","https://openalex.org/W1599183696","https://openalex.org/W1606239426","https://openalex.org/W1717942436","https://openalex.org/W1889077695","https://openalex.org/W1983970471","https://openalex.org/W1999774322","https://openalex.org/W2005958417","https://openalex.org/W2011438247","https://openalex.org/W2012204327","https://openalex.org/W2018224785","https://openalex.org/W2025591497","https://openalex.org/W2026220869","https://openalex.org/W2028932104","https://openalex.org/W2040806338","https://openalex.org/W2062138021","https://openalex.org/W2066085528","https://openalex.org/W2070248787","https://openalex.org/W2079335613","https://openalex.org/W2345138396","https://openalex.org/W2416086701","https://openalex.org/W2418492336","https://openalex.org/W2429598875","https://openalex.org/W2613467369","https://openalex.org/W2934405720","https://openalex.org/W4230113182"],"related_works":["https://openalex.org/W1524025209","https://openalex.org/W2070248787","https://openalex.org/W2003333173","https://openalex.org/W2345138396","https://openalex.org/W1536491514","https://openalex.org/W2047195852","https://openalex.org/W2426567815","https://openalex.org/W1507002498","https://openalex.org/W2028932104","https://openalex.org/W2098105689"],"abstract_inverted_index":{"Chicken":[0],"liver":[1],"xanthine":[2,10,59,148],"dehydrogenase":[3,60],"can":[4],"be":[5],"partially":[6],"reduced":[7,58],"by":[8,61,86],"either":[9,62],"or":[11,64,113],"NADH.":[12],"Reduction":[13],"to":[14,98,108,117],"approximately":[15],"the":[16,25,34,49,71,78,87,99,102,124,141],"2-electron-reduced":[17,118],"level":[18,27,80],"occurs":[19,28],"with":[20,29],"NADH,":[21],"and":[22,40,68,149],"reduction":[23,82],"beyond":[24],"2-electron":[26],"xanthine.":[30],"In":[31],"both":[32],"cases,":[33],"reaction":[35],"is":[36,52,66,96,105,120,137],"triphasic.":[37],"The":[38,90],"first":[39],"third":[41],"phases":[42],"are":[43],"dependent":[44,69],"on":[45,70],"reductant":[46],"concentration,":[47],"whereas":[48,134],"second":[50],"phase":[51],"not.":[53],"Oxidation":[54,74],"of":[55,81,92,101,111,144],"fully":[56],"(6-electron)":[57],"urate":[63,135],"NAD":[65],"monophasic":[67],"oxidant":[72,112],"concentration.":[73],"stops":[75],"at":[76],"about":[77],"same":[79],"that":[83],"was":[84],"reached":[85],"corresponding":[88],"reductant.":[89,114],"position":[91,127],"this":[93],"end":[94,125,142],"point":[95,126,143],"sensitive":[97],"potential":[100],"reactants":[103],"but":[104],"relatively":[106],"insensitive":[107],"excess":[109],"concentrations":[110],"NADH":[115],"binding":[116,136],"enzyme":[119],"implicated":[121],"in":[122,128,139],"fixing":[123,140],"those":[129,145],"reactions":[130,146],"involving":[131,147],"pyridine":[132],"nucleotides,":[133],"involved":[138],"urate.":[150]},"counts_by_year":[{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
