{"id":"https://openalex.org/W22958689","doi":null,"title":"Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization.","display_name":"Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W22958689","mag":"22958689","pmid":"https://pubmed.ncbi.nlm.nih.gov/8479150"},"language":"en","primary_location":{"id":"pmid:8479150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012410823","display_name":"Ulrich H. Rudofsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U H Rudofsky","raw_affiliation_strings":["Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480824","display_name":"B D Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797954","display_name":"S L Balaban","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Balaban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013509462","display_name":"Vilma D. Mottironi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V D Mottironi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110841480","display_name":"ANN E. GABRIELSEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Gabrielsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6134,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.79561018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"68","issue":"4","first_page":"419","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autoimmune-glomerulonephritis","display_name":"autoimmune glomerulonephritis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/h-2-complex","display_name":"H-2 complex","score":0.5830000042915344},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.796999990940094},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.9629999995231628},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.6769999861717224},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.597000002861023},{"id":"https://openalex.org/keywords/complement-c5","display_name":"complement C5","score":0.5929999947547913},{"id":"https://openalex.org/keywords/reassortment","display_name":"reassortment","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7551608681678772},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.6390330791473389},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6244000196456909},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.6126378774642944},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.595135509967804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5383817553520203},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.5223885178565979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4932863116264343},{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.47437864542007446},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4424920380115509},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.41638895869255066},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3995285928249359},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32438671588897705},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3062552511692047},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2838228940963745},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.26910945773124695},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.2390020787715912},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15630599856376648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11678114533424377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10998636484146118}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000822","descriptor_name":"Animal Husbandry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006824","descriptor_name":"Hybridization, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8479150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:22958689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5654729035","display_name":"DIFFERENTIAL EXPRESSION OF SLE IN NZB/NZW RI MICE","funder_award_id":"R01DK041923","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2159524775","https://openalex.org/W1580839177","https://openalex.org/W2144376568","https://openalex.org/W2103862350","https://openalex.org/W2100023355","https://openalex.org/W2089342771","https://openalex.org/W2143915650","https://openalex.org/W2118109560","https://openalex.org/W1972661406","https://openalex.org/W2110777831","https://openalex.org/W2168209836","https://openalex.org/W2107290206","https://openalex.org/W2036649899","https://openalex.org/W2053999166","https://openalex.org/W2088488258","https://openalex.org/W2001967789","https://openalex.org/W2049207389","https://openalex.org/W2144025503","https://openalex.org/W2113495166","https://openalex.org/W2131828349"],"related_works":["https://openalex.org/W7099899043","https://openalex.org/W2070693829","https://openalex.org/W1971133807","https://openalex.org/W2142307845","https://openalex.org/W1519286526","https://openalex.org/W1570075263","https://openalex.org/W7096226755","https://openalex.org/W2158738842","https://openalex.org/W7097820923","https://openalex.org/W1995030846"],"abstract_inverted_index":{"BACKGROUND:":[0],"F1":[1,73],"hybrids":[2],"of":[3,50,71,80,91,93,102,120,126,148,160,170,196,208,263,267,282,292,298,307,335,356,362,368,372,388],"New":[4,9,77,81],"Zealand":[5,10,82],"Black":[6],"(NZB)":[7],"and":[8,29,48,98,128,136,150,194,238,245,252,258,358,364],"White":[11],"(NZW)":[12],"mice":[13,30,85,254,293,343],"develop":[14],"autoimmune":[15,25],"glomerulonephritis":[16],"resembling":[17],"human":[18],"lupus":[19,171],"nephritis.":[20],"Susceptibility":[21],"to":[22,34,117,122,145,247,314,383],"this":[23],"complex":[24,43],"syndrome":[26],"in":[27,37,131,173,182,189,278,317,337,379],"humans":[28],"has":[31],"been":[32,377],"linked":[33],"genes":[35,65,371],"mapping":[36],"or":[38,261],"near":[39],"the":[40,72,103,124,158,176,200,221,249,259,264,283,308,324,333,338,353,359,385],"major":[41,62],"histocompatibility":[42,63],"that":[44,57,66,215,301,312,323,351],"govern":[45],"immune":[46],"responses":[47],"levels":[49],"certain":[51],"complement":[52,269],"components.":[53],"Previous":[54],"studies":[55],"showed":[56,214],"both":[58,352,373],"parental":[59,310],"strains":[60,79,107,167,184,204,217,285,291,300,311,375,382],"contribute":[61],"complex-linked":[64],"are":[67,218,294],"important":[68],"for":[69,110,115,142,157,220,231,329,332],"disease":[70,132,186,318],"hybrid.":[74],"EXPERIMENTAL":[75],"DESIGN:":[76],"inbred":[78,299],"Mixed":[83],"(NZM)":[84],"were":[86,108,113,140,155,276],"derived":[87],"by":[88],"selective":[89],"inbreeding":[90],"progeny":[92],"a":[94,202,295,365],"cross":[95],"between":[96],"NZB":[97,149,357],"NZW":[99,151,222,363],"mice.":[100],"Twelve":[101],"27":[104],"new":[105,381],"NZM":[106,166,284,290],"selected":[109],"analysis.":[111],"Mice":[112],"observed":[114],"up":[116],"10":[118],"months":[119],"age":[121],"document":[123],"occurrence":[125],"nephritis":[127,172,197,336],"strain-specific":[129],"differences":[130,316],"expression.":[133,319],"H-2,":[134],"Hc,":[135],"coat":[137],"color":[138,229],"loci":[139,233],"determined":[141],"each":[143],"strain":[144],"establish":[146],"homozygosity":[147],"polymorphic":[152],"markers.":[153],"Strains":[154],"screened":[156],"presence":[159,260],"anti-dsDNA":[161],"autoantibodies.":[162],"RESULTS:":[163],"In":[164],"some":[165],"early":[168,185],"onset":[169],"females":[174],"resembled":[175],"(NZB":[177,339],"x":[178,340],"NZW)F1":[179,341],"model,":[180],"whereas":[181],"other":[183,369],"also":[187],"occurred":[188],"males.":[190],"Age":[191],"at":[192],"death":[193],"severity":[195],"vary":[198],"among":[199],"lines;":[201],"few":[203],"remain":[205],"relatively":[206],"free":[207],"glomerular":[209],"lesions.":[210],"Histocompatibility":[211],"(H-2)":[212],"typing":[213],"all":[216,279],"homozygous":[219],"haplotype":[223],"(Ku,":[224],"Au,":[225],"Sz,":[226],"Dz).":[227],"Coat":[228],"analysis":[230],"four":[232],"on":[234],"chromosomes":[235],"2,":[236],"4,":[237],"7":[239],"was":[240],"consistent":[241],"with":[242,255],"specific":[243],"reassortments":[244],"recombinations":[246],"explain":[248],"grey,":[250],"tan,":[251],"white":[253],"red/pink":[256],"eyes":[257],"absence":[262],"fifth":[265],"component":[266],"serum":[268],"(C5)":[270],"(Hc,":[271],"chromosome":[272],"2).":[273],"Anti-dsDNA":[274],"autoantibodies":[275],"found":[277],"but":[280],"one":[281],"reported":[286],"here.":[287],"CONCLUSIONS:":[288],"The":[289],"unique":[296],"set":[297],"have":[302,376],"inherited":[303],"various":[304,386],"genomic":[305],"segments":[306],"two":[309],"lead":[313],"phenotypic":[315],"These":[320],"results":[321],"indicate":[322],"previously":[325],"proposed":[326],"strict":[327],"requirement":[328],"H-2":[330],"heterozygosity":[331],"development":[334],"hybrid":[342],"may":[344],"not":[345],"be":[346],"valid.":[347],"It":[348],"is":[349],"assumed":[350],"Lpn-1":[354],"locus":[355,361],"Lpn-2":[360],"sufficient":[366],"number":[367],"disease-associated":[370],"ancestral":[374],"recombined":[378],"these":[380],"produce":[384],"patterns":[387],"renal":[389],"disease.":[390]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}