{"id":"https://openalex.org/W2295747577","doi":"https://doi.org/10.6004/jnccn.2016.0038","title":"Fertility Preservation in Patients With Breast Cancer: Necessity, Methods, and Safety","display_name":"Fertility Preservation in Patients With Breast Cancer: Necessity, Methods, and Safety","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2295747577","doi":"https://doi.org/10.6004/jnccn.2016.0038","mag":"2295747577","pmid":"https://pubmed.ncbi.nlm.nih.gov/26957619"},"language":"en","primary_location":{"id":"doi:10.6004/jnccn.2016.0038","doi":"https://doi.org/10.6004/jnccn.2016.0038","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2016.0038","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/14/3/article-p355.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnccn.org/downloadpdf/journals/jnccn/14/3/article-p355.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089866079","display_name":"Adrienne Gropper Waks","orcid":"https://orcid.org/0000-0001-5649-7229","observed_orcids":["https://orcid.org/0000-0001-5649-7229"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne G. Waks","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts","Department of Medical Oncology, Dana-Farber Cancer Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, and","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039694693","display_name":"Ann H. Partridge","orcid":"https://orcid.org/0000-0002-4722-4824","observed_orcids":["https://orcid.org/0000-0002-4722-4824"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann H. Partridge","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts","Department of Medical Oncology, Dana-Farber Cancer Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, and","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039694693"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":0.886,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.66121017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"3","first_page":"355","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fertility-preservation","display_name":"fertility preservation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.6269999742507935},{"id":"https://openalex.org/keywords/chemotherapy-induced-premature-ovarian-failure","display_name":"chemotherapy-induced ovarian failure","score":0.574999988079071},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fertility-sparing-treatment","display_name":"fertility-sparing treatment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/patient-centered-care","display_name":"patient-centered care","score":0.5709999799728394},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8561108708381653},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.821843683719635},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7797751426696777},{"id":"https://openalex.org/C2777904497","wikidata":"https://www.wikidata.org/wiki/Q5445580","display_name":"Fertility preservation","level":4,"score":0.768261194229126},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5600883960723877},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.48783066868782043},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.46016332507133484},{"id":"https://openalex.org/C2778970755","wikidata":"https://www.wikidata.org/wiki/Q7092085","display_name":"Oncofertility","level":5,"score":0.45566242933273315},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37300556898117065},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3550652861595154},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3302893340587616},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.18931272625923157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18606501817703247},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08672308921813965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059247","descriptor_name":"Fertility Preservation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.6004/jnccn.2016.0038","doi":"https://doi.org/10.6004/jnccn.2016.0038","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2016.0038","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/14/3/article-p355.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},{"id":"pmid:26957619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26957619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network : JNCCN","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.6004/jnccn.2016.0038","doi":"https://doi.org/10.6004/jnccn.2016.0038","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2016.0038","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/14/3/article-p355.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2295747577.pdf","grobid_xml":"https://content.openalex.org/works/W2295747577.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W265316258","https://openalex.org/W776503986","https://openalex.org/W1505571525","https://openalex.org/W1514520056","https://openalex.org/W1517901808","https://openalex.org/W1520834658","https://openalex.org/W1565820605","https://openalex.org/W1909927350","https://openalex.org/W1947641090","https://openalex.org/W1955291661","https://openalex.org/W1964972487","https://openalex.org/W1964979154","https://openalex.org/W1969384903","https://openalex.org/W1970200203","https://openalex.org/W1977866223","https://openalex.org/W1988357712","https://openalex.org/W1989639467","https://openalex.org/W1991238536","https://openalex.org/W1995664887","https://openalex.org/W1997481556","https://openalex.org/W1999289481","https://openalex.org/W2002561854","https://openalex.org/W2031942208","https://openalex.org/W2041752474","https://openalex.org/W2043622311","https://openalex.org/W2056046292","https://openalex.org/W2060714167","https://openalex.org/W2061215876","https://openalex.org/W2063500255","https://openalex.org/W2073552868","https://openalex.org/W2100196672","https://openalex.org/W2103606500","https://openalex.org/W2105535059","https://openalex.org/W2117163620","https://openalex.org/W2118696602","https://openalex.org/W2120398882","https://openalex.org/W2122427886","https://openalex.org/W2123533470","https://openalex.org/W2132412251","https://openalex.org/W2139473755","https://openalex.org/W2140861147","https://openalex.org/W2142075003","https://openalex.org/W2146519887","https://openalex.org/W2151996914","https://openalex.org/W2155902341","https://openalex.org/W2160715479","https://openalex.org/W2169649287","https://openalex.org/W2175023956","https://openalex.org/W2259181940","https://openalex.org/W2313537190","https://openalex.org/W2317969315","https://openalex.org/W2326819825","https://openalex.org/W2408643946","https://openalex.org/W2602458953","https://openalex.org/W2954748426","https://openalex.org/W4244186096","https://openalex.org/W4298128509"],"related_works":["https://openalex.org/W4205240028","https://openalex.org/W4316042065","https://openalex.org/W2336831610","https://openalex.org/W3097980596","https://openalex.org/W7160035570","https://openalex.org/W4226065302","https://openalex.org/W3130082910","https://openalex.org/W4380537297","https://openalex.org/W7118180697","https://openalex.org/W3093232865"],"abstract_inverted_index":{"As":[0],"treatment":[1,51,106],"paradigms":[2],"improve":[3],"and":[4,53,61,80,99],"young":[5,126],"women":[6,26],"live":[7],"longer":[8],"after":[9],"a":[10,118],"breast":[11,28,49,90,122],"cancer":[12,29,50,91,123],"diagnosis,":[13],"there":[14],"is":[15,41],"an":[16],"increasing":[17],"need":[18],"to":[19,34,121],"define":[20],"the":[21,71,85,104,112],"fertility-related":[22,101],"problems":[23],"that":[24,56],"premenopausal":[25],"with":[27,47],"face,":[30],"and,":[31],"more":[32],"importantly,":[33],"find":[35],"solutions.":[36],"This":[37],"article":[38],"discusses":[39],"what":[40],"known":[42],"regarding":[43],"fertility":[44,65],"risks":[45],"associated":[46],"standard":[48],"regimens":[52],"limitations":[54],"of":[55,74,87,114],"information.":[57],"We":[58,93],"outline":[59],"established":[60],"emerging":[62],"techniques":[63],"for":[64,96,125],"preservation,":[66],"including":[67],"recent":[68],"developments":[69],"surrounding":[70],"controversial":[72],"utility":[73],"gonadotropin-releasing":[75],"hormone":[76],"agonists":[77],"through":[78],"chemotherapy,":[79],"review":[81],"available":[82],"data":[83],"on":[84],"safety":[86],"pregnancy":[88],"in":[89,103,117],"survivors.":[92],"highlight":[94],"opportunities":[95],"further":[97],"investigation,":[98],"contextualize":[100],"concerns":[102],"modern":[105],"landscape.":[107],"Above":[108],"all,":[109],"we":[110],"stress":[111],"importance":[113],"this":[115],"topic":[116],"patient-centered":[119],"approach":[120],"care":[124],"women.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
