{"id":"https://openalex.org/W22957010","doi":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","title":"Gene Expression in the Addicted Brain","display_name":"Gene Expression in the Addicted Brain","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W22957010","doi":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","mag":"22957010","pmid":"https://pubmed.ncbi.nlm.nih.gov/25172478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427035"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-801105-8.00010-2","doi":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","pdf_url":null,"source":{"id":"https://openalex.org/S59060466","display_name":"International review of neurobiology","issn_l":"0074-7742","issn":["0074-7742","2162-5514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Review of Neurobiology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4234676903","display_name":"Brain Transcriptome"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055995873","display_name":"Zhifeng Zhou","orcid":"https://orcid.org/0000-0003-1716-3976","observed_orcids":["https://orcid.org/0000-0003-1716-3976"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhifeng Zhou","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: zhouz@mail.nih.gov","Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: zhouz@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111819900","display_name":"Mary\u2010Anne Enoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary-Anne Enoch","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041766549","display_name":"David A Goldman","orcid":"https://orcid.org/0000-0002-1724-5405","observed_orcids":["https://orcid.org/0000-0002-1724-5405"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Goldman","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4511,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.95251662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"116","issue":null,"first_page":"251","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/neural-adaptation","display_name":"neural adaptation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":1.0},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9980000257492065},{"id":"https://openalex.org/keywords/withdrawal","display_name":"withdrawal","score":0.5870000123977661},{"id":"https://openalex.org/keywords/brain-regions","display_name":"brain regions","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8603918552398682},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7946667671203613},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.63770991563797},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.622978687286377},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5788190364837646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5300554633140564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4426656663417816},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41305696964263916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4005363881587982},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3761228621006012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23867425322532654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/b978-0-12-801105-8.00010-2","doi":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-801105-8.00010-2","pdf_url":null,"source":{"id":"https://openalex.org/S59060466","display_name":"International review of neurobiology","issn_l":"0074-7742","issn":["0074-7742","2162-5514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Review of Neurobiology","raw_type":"book-chapter"},{"id":"pmid:25172478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25172478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International review of neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3388413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4427035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int Rev Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3388413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2746829988","display_name":"Intermediate Phenotypes for Alcoholism and Whole Genome Linkage Scan","funder_award_id":"Z01AA000280","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8158493685","display_name":"Gene-Environment Interations Underlying Alcoholism Vulnerability Disorders","funder_award_id":"Z01AA000306","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1532530881","https://openalex.org/W1536218996","https://openalex.org/W1553398873","https://openalex.org/W1582233022","https://openalex.org/W1610317949","https://openalex.org/W1645632161","https://openalex.org/W1674012705","https://openalex.org/W1777871578","https://openalex.org/W1901828236","https://openalex.org/W1926838596","https://openalex.org/W1966449636","https://openalex.org/W1967177629","https://openalex.org/W1968454394","https://openalex.org/W1968578486","https://openalex.org/W1970565325","https://openalex.org/W1976049724","https://openalex.org/W1977129180","https://openalex.org/W1977929159","https://openalex.org/W1980260287","https://openalex.org/W1989416066","https://openalex.org/W1990027430","https://openalex.org/W1991558794","https://openalex.org/W1992093579","https://openalex.org/W1995796138","https://openalex.org/W1995912013","https://openalex.org/W1997540962","https://openalex.org/W1998352623","https://openalex.org/W2002799533","https://openalex.org/W2006023388","https://openalex.org/W2006944269","https://openalex.org/W2008504970","https://openalex.org/W2010735934","https://openalex.org/W2011275122","https://openalex.org/W2014943258","https://openalex.org/W2015416439","https://openalex.org/W2016441739","https://openalex.org/W2018652969","https://openalex.org/W2019164907","https://openalex.org/W2020292060","https://openalex.org/W2022644512","https://openalex.org/W2022851859","https://openalex.org/W2025192622","https://openalex.org/W2027344089","https://openalex.org/W2029028897","https://openalex.org/W2031323742","https://openalex.org/W2034739161","https://openalex.org/W2037717401","https://openalex.org/W2038948091","https://openalex.org/W2041018266","https://openalex.org/W2041253023","https://openalex.org/W2042377182","https://openalex.org/W2043351817","https://openalex.org/W2045289070","https://openalex.org/W2048592343","https://openalex.org/W2049796382","https://openalex.org/W2052532655","https://openalex.org/W2053544091","https://openalex.org/W2053931216","https://openalex.org/W2055423122","https://openalex.org/W2055452395","https://openalex.org/W2057318985","https://openalex.org/W2057583356","https://openalex.org/W2059712345","https://openalex.org/W2066848874","https://openalex.org/W2072329780","https://openalex.org/W2074073259","https://openalex.org/W2078995190","https://openalex.org/W2081147113","https://openalex.org/W2082455141","https://openalex.org/W2082964100","https://openalex.org/W2083245183","https://openalex.org/W2084444079","https://openalex.org/W2094750093","https://openalex.org/W2097740807","https://openalex.org/W2100404884","https://openalex.org/W2102261636","https://openalex.org/W2104261628","https://openalex.org/W2106357844","https://openalex.org/W2107844030","https://openalex.org/W2113889584","https://openalex.org/W2114005002","https://openalex.org/W2115129188","https://openalex.org/W2120455982","https://openalex.org/W2121423419","https://openalex.org/W2124006023","https://openalex.org/W2126884841","https://openalex.org/W2130496333","https://openalex.org/W2139968781","https://openalex.org/W2154538414","https://openalex.org/W2159447534","https://openalex.org/W2161933077","https://openalex.org/W2163674751","https://openalex.org/W2164944170","https://openalex.org/W7073838808"],"related_works":["https://openalex.org/W2889139211","https://openalex.org/W4240302459","https://openalex.org/W2614933292","https://openalex.org/W4220748783","https://openalex.org/W2199339900","https://openalex.org/W1976070593","https://openalex.org/W1968101691","https://openalex.org/W2501402881","https://openalex.org/W2955926962","https://openalex.org/W2931032935"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}