{"id":"https://openalex.org/W2295670602","doi":null,"title":"Melatonin modulates intercellular communication among immortalized rat suprachiasmatic nucleus cells","display_name":"Melatonin modulates intercellular communication among immortalized rat suprachiasmatic nucleus cells","publication_year":2009,"publication_date":"2009-05-15","ids":{"openalex":"https://openalex.org/W2295670602","mag":"2295670602"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-2436","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-2436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016253026","display_name":"Kimberly Yvonne Cox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kimberly Yvonne Cox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016253026"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9079999923706055},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/calcium-waves","display_name":"calcium waves","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gliotransmission","display_name":"gliotransmission","score":0.949999988079071},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.9660000205039978},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dye-coupling","display_name":"dye coupling","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.8964800834655762},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7328829765319824},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5504978895187378},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5084458589553833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47881489992141724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44216951727867126},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43855154514312744},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.42196744680404663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35324299335479736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34124627709388733}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-2436","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-2436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2295670602","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/bitstream/1969.1/ETD-TAMU-2436/1/COX-THESIS.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1495842154","https://openalex.org/W1535641516","https://openalex.org/W1544391143","https://openalex.org/W1586815960","https://openalex.org/W1812122914","https://openalex.org/W1815757713","https://openalex.org/W1852348769","https://openalex.org/W1954747488","https://openalex.org/W1963758132","https://openalex.org/W1964405560","https://openalex.org/W1970549117","https://openalex.org/W1975979472","https://openalex.org/W1979779439","https://openalex.org/W1980900081","https://openalex.org/W1984299330","https://openalex.org/W1986413865","https://openalex.org/W1997456365","https://openalex.org/W2000193264","https://openalex.org/W2001011075","https://openalex.org/W2017203200","https://openalex.org/W2017547179","https://openalex.org/W2019955714","https://openalex.org/W2024213283","https://openalex.org/W2024773604","https://openalex.org/W2030314341","https://openalex.org/W2034565593","https://openalex.org/W2034722980","https://openalex.org/W2034899304","https://openalex.org/W2036120795","https://openalex.org/W2039931639","https://openalex.org/W2041733022","https://openalex.org/W2044730840","https://openalex.org/W2050926729","https://openalex.org/W2051113383","https://openalex.org/W2052079679","https://openalex.org/W2052495302","https://openalex.org/W2056482899","https://openalex.org/W2059257618","https://openalex.org/W2060140960","https://openalex.org/W2062731661","https://openalex.org/W2065225923","https://openalex.org/W2066227849","https://openalex.org/W2067102106","https://openalex.org/W2068517470","https://openalex.org/W2073622913","https://openalex.org/W2076217882","https://openalex.org/W2081244622","https://openalex.org/W2084548151","https://openalex.org/W2086712670","https://openalex.org/W2087434578","https://openalex.org/W2088369645","https://openalex.org/W2090856094","https://openalex.org/W2095541358","https://openalex.org/W2098712686","https://openalex.org/W2100132948","https://openalex.org/W2102724058","https://openalex.org/W2102747751","https://openalex.org/W2111561559","https://openalex.org/W2111757703","https://openalex.org/W2113022661","https://openalex.org/W2116473569","https://openalex.org/W2116763991","https://openalex.org/W2117088742","https://openalex.org/W2120613443","https://openalex.org/W2127339663","https://openalex.org/W2135343497","https://openalex.org/W2136386853","https://openalex.org/W2136867476","https://openalex.org/W2139238458","https://openalex.org/W2141260882","https://openalex.org/W2141480740","https://openalex.org/W2147267096","https://openalex.org/W2147322410","https://openalex.org/W2151644727","https://openalex.org/W2151984162","https://openalex.org/W2152002273","https://openalex.org/W2152904049","https://openalex.org/W2158972964","https://openalex.org/W2159774787","https://openalex.org/W2162109886","https://openalex.org/W2162175309","https://openalex.org/W2166891559","https://openalex.org/W2323516874"],"related_works":["https://openalex.org/W2594489574","https://openalex.org/W1939208066","https://openalex.org/W2290112318","https://openalex.org/W2242275595","https://openalex.org/W7135794656","https://openalex.org/W2060251672","https://openalex.org/W1998887722","https://openalex.org/W1763822794","https://openalex.org/W2049929803","https://openalex.org/W2345683658"],"abstract_inverted_index":{"The":[0,88],"mammalian":[1],"brain":[2],"contains":[3,23],"a":[4,16,179,194,225,283],"regulatory":[5],"center":[6],"in":[7,19,70,113,156,171,188,207,213,238,259],"the":[8,40,45,65,71,86,91,104,108,126,151,160,198,208,274,299],"diencephalic":[9],"region":[10],"known":[11],"as\\nthe":[12],"hypothalamus":[13,38],"that":[14,55,176,282],"plays":[15],"critical":[17,56],"role":[18],"physiological":[20,167,180,277],"homeostasis,":[21],"and":[22,33,52,69,140,256,265,291],"a\\nvariety":[24],"of":[25,64,90,107,153,210,261,273,307],"centers":[26],"for":[27,80],"behavioral":[28],"drives,":[29],"such":[30,54],"as":[31,111,191],"hunger":[32],"thirst.":[34],"Located":[35],"deep":[36],"within\\nthe":[37],"is":[39,78],"suprachiasmatic":[41],"nucleus":[42],"(SCN),":[43],"or":[44,67],"master":[46],"biological":[47],"clock,\\nthat":[48],"organizes":[49],"rhythmic":[50],"physiology":[51],"behavior,":[53],"events":[57],"take":[58],"place":[59],"at\\nthe":[60],"most":[61,72],"appropriate":[62,73],"time":[63],"day":[66],"night":[68],"temporal,":[74],"phase\\nrelationships.":[75],"Cell-to-cell":[76],"communication":[77,120],"essential":[79],"conveying":[81],"inputs":[82],"to":[83,95,117,164,169,304],"and\\noutputs":[84],"from":[85,103],"SCN.":[87],"goal":[89],"present":[92],"study":[93,118],"was":[94,173,231,246,268],"use":[96],"an":[97,112,234],"immortalized":[98],"neural\\ncell":[99],"line":[100],"(SCN2.2),":[101],"derived":[102],"presumptive":[105],"anlage":[106],"rat":[109],"suprachiasmatic\\nnucleus,":[110],"vitro":[114],"model":[115],"system":[116],"intercellular":[119],"among":[121],"SCN\\ncells.":[122],"I":[123,144,280],"tested":[124,146],"whether":[125,147],"pineal":[127],"neurohormone":[128],"melatonin":[129,170,177,255,289],"could":[130],"modulate":[131,165],"cell-to-cell\\nsignaling,":[132],"via":[133],"both":[134],"dye":[135,200],"coupling":[136],"(gap":[137,185],"junctional":[138,186],"communication)":[139,187],"calcium":[141,154,211,220,226],"waves\\n(ATP-dependent":[142],"gliotransmission).":[143],"also":[145,269],"extracellular":[148,239,251],"ATP":[149,163,240,257,295],"could\\ninfluence":[150],"spread":[152,209],"waves":[155,212],"SCN2.2":[157,189,215],"cells.":[158],"Lastly,":[159],"ability":[161],"of\\nextracellular":[162],"SCN":[166,276,308],"responses":[168],"SCN2.2\\ncells":[172],"examined.\\nI":[174],"show":[175],"at":[178,247],"concentration":[181],"(nM)":[182],"reduced":[183],"dye\\ncoupling":[184],"cells,":[190],"determined":[192,242],"by":[193,218,243],"scrape\\nloading":[195],"procedure":[196],"employing":[197],"fluorescent":[199],"lucifer":[201],"yellow.":[202],"Melatonin":[203],"caused":[204],"a\\nsignificant":[205],"reduction":[206,230],"cycling":[214,306],"cultures":[216],"as\\ndetermined":[217],"ratiometric":[219],"imaging":[221],"with":[222,298],"Fura-2":[223],"AM,":[224],"sensitive\\nindicator":[227],"dye.":[228],"This":[229],"greatest":[232],"when":[233],"endogenous":[235,275,305],"circadian":[236],"rhythm":[237],"accumulation,":[241],"luciferase":[244],"assay,":[245],"its":[248],"trough":[249],"or\\nlowest":[250],"concentration.":[252],"In":[253],"addition,":[254],"interacted":[258],"the\\nregulation":[260],"gliotransmission":[262],"(calcium":[263],"waves),":[264],"this":[266,292,301],"interaction":[267,285],"specific":[270],"to\\nparticular":[271],"phases":[272],"rhythmicity.":[278],"Thus,":[279],"have\\nestablished":[281],"complex":[284],"exists":[286],"between":[287],"established":[288],"signaling\\npathways":[290],"newly":[293],"discovered":[294],"accumulation":[296],"rhythm,":[297],"mechanisms\\nunderlying":[300],"relationship":[302],"linked":[303],"cellular":[309],"physiology.":[310]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}
