{"id":"https://openalex.org/W2295458758","doi":"https://doi.org/10.1007/978-3-319-12262-5_64","title":"Therapeutic Time Window for rt-PA Thrombolysis in a Rat Photothrombotic Ischemic Stroke Model","display_name":"Therapeutic Time Window for rt-PA Thrombolysis in a Rat Photothrombotic Ischemic Stroke Model","publication_year":2014,"publication_date":"2014-09-23","ids":{"openalex":"https://openalex.org/W2295458758","doi":"https://doi.org/10.1007/978-3-319-12262-5_64","mag":"2295458758"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-12262-5_64","doi":"https://doi.org/10.1007/978-3-319-12262-5_64","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-12262-5_64","pdf_url":null,"source":{"id":"https://openalex.org/S4210169992","display_name":"World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany","issn_l":"1433-9277","issn":["1433-9277","1680-0737","1727-1983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IFMBE Proceedings","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2497685384","display_name":"1st Global Conference on Biomedical Engineering &amp; 9th Asian-Pacific Conference on Medical and Biological Engineering"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083932557","display_name":"Aishwarya Bandla","orcid":"https://orcid.org/0000-0002-6705-1318","observed_orcids":["https://orcid.org/0000-0002-6705-1318"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Aishwarya Bandla","raw_affiliation_strings":["Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore","Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061954083","display_name":"Ji Min Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210131313","display_name":"National Neuroscience Institute","ror":"https://ror.org/03d58dr58","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210131313"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ji Min Ling","raw_affiliation_strings":["Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore","Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore","institution_ids":["https://openalex.org/I4210131313"]},{"raw_affiliation_string":"Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739796","display_name":"Yu\u2010Hang Liu","orcid":"https://orcid.org/0000-0003-0629-3150","observed_orcids":["https://orcid.org/0000-0003-0629-3150"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yu-Hang Liu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore","Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039581077","display_name":"Hsin\u2010Yi Lai","orcid":"https://orcid.org/0000-0001-6413-0179","observed_orcids":["https://orcid.org/0000-0001-6413-0179"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093734","display_name":"Taoyuan Chang Gung Memorial Hospital","ror":"https://ror.org/00fk9d670","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093734"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yi Lai","raw_affiliation_strings":["Department of Physical Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210093734","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003072693","display_name":"You\u2010Yin Chen","orcid":"https://orcid.org/0000-0003-4869-3857","observed_orcids":["https://orcid.org/0000-0003-4869-3857"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"You-Yin Chen","raw_affiliation_strings":["Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088964967","display_name":"Nitish V. Thakor","orcid":"https://orcid.org/0000-0002-9981-9395","observed_orcids":["https://orcid.org/0000-0002-9981-9395"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Nitish V. Thakor","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA","Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore","Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore","Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054022377","display_name":"Lun\u2010De Liao","orcid":"https://orcid.org/0000-0002-2601-3673","observed_orcids":["https://orcid.org/0000-0002-2601-3673"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Lun-De Liao","raw_affiliation_strings":["Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5054022377"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.22539098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"231","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rt-pa-thrombolysis","display_name":"rt-PA thrombolysis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.8679999709129333},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.8759999871253967},{"id":"https://openalex.org/keywords/treatment-window","display_name":"therapeutic time window","score":0.953000009059906},{"id":"https://openalex.org/keywords/electrocorticography","display_name":"electrocorticography","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neuronal-activity","display_name":"neuronal activity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neurovascular-function","display_name":"neurovascular function","score":0.8100000023841858},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.9257206916809082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7305276393890381},{"id":"https://openalex.org/C2911092318","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Recombinant tissue plasminogen activator","level":5,"score":0.6471987366676331},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.6205331087112427},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.6133202314376831},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5821846127510071},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5041905641555786},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5032309889793396},{"id":"https://openalex.org/C46622094","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic window","level":2,"score":0.44283461570739746},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4104991853237152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34838640689849854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.343990296125412},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32266563177108765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19620084762573242},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19401085376739502},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.11989772319793701},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-319-12262-5_64","doi":"https://doi.org/10.1007/978-3-319-12262-5_64","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-12262-5_64","pdf_url":null,"source":{"id":"https://openalex.org/S4210169992","display_name":"World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany","issn_l":"1433-9277","issn":["1433-9277","1680-0737","1727-1983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IFMBE Proceedings","raw_type":"book-chapter"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/127704","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/127704","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2727213267","https://openalex.org/W2321705486","https://openalex.org/W3103980401","https://openalex.org/W2537115956","https://openalex.org/W2050115379","https://openalex.org/W3080283655","https://openalex.org/W3044671826","https://openalex.org/W1919929830","https://openalex.org/W2157827475","https://openalex.org/W2625963031"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
