{"id":"https://openalex.org/W2294941279","doi":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","title":"Cryomicroscopic analysis of freezing in liver of the freeze-tolerant wood frog","display_name":"Cryomicroscopic analysis of freezing in liver of the freeze-tolerant wood frog","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2294941279","doi":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","mag":"2294941279","pmid":"https://pubmed.ncbi.nlm.nih.gov/1636785"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1992.263.1.r185","doi":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074785536","display_name":"Kenneth B. Storey","orcid":"https://orcid.org/0000-0002-7363-1853","observed_orcids":["https://orcid.org/0000-0002-7363-1853"]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. B. Storey","raw_affiliation_strings":["Department of Biology, Carleton University, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Carleton University, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I67031392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045309865","display_name":"John C. Bischof","orcid":"https://orcid.org/0000-0001-6726-7111","observed_orcids":["https://orcid.org/0000-0001-6726-7111"]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Bischof","raw_affiliation_strings":["Department of Biology, Carleton University, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Carleton University, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I67031392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080256488","display_name":"Boris Rubinsky","orcid":"https://orcid.org/0000-0002-2794-1543","observed_orcids":["https://orcid.org/0000-0002-2794-1543"]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. Rubinsky","raw_affiliation_strings":["Department of Biology, Carleton University, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Carleton University, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I67031392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I67031392"],"apc_list":null,"apc_paid":null,"fwci":3.0179,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.90816773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"263","issue":"1","first_page":"R185","last_page":"R194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13679","display_name":"Tardigrade Biology and Ecology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12180","display_name":"Polar Research and Ecology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/freeze-tolerance","display_name":"freezing tolerance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/wood-frog","display_name":"wood frog","score":1.0},{"id":"https://openalex.org/keywords/intracellular-ice-formation","display_name":"intracellular ice formation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/directional-solidification","display_name":"directional solidification","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cryoprotectants","display_name":"cryoprotectants","score":0.6679999828338623},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.640999972820282},{"id":"https://openalex.org/keywords/freezing-survival","display_name":"freezing survival","score":0.6349999904632568},{"id":"https://openalex.org/keywords/low-temperature-scanning-electron-microscopy","display_name":"low-temperature scanning electron microscopy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cryomicroscopy","display_name":"cryomicroscopy","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C68528507","wikidata":"https://www.wikidata.org/wiki/Q692267","display_name":"Cryoprotectant","level":4,"score":0.8408238291740417},{"id":"https://openalex.org/C2778769901","wikidata":"https://www.wikidata.org/wiki/Q194290","display_name":"Dehydration","level":2,"score":0.7861683368682861},{"id":"https://openalex.org/C2776727640","wikidata":"https://www.wikidata.org/wiki/Q2822759","display_name":"Freezing tolerance","level":3,"score":0.569868803024292},{"id":"https://openalex.org/C95053279","wikidata":"https://www.wikidata.org/wiki/Q672832","display_name":"Cryobiology","level":4,"score":0.5270624160766602},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.524882972240448},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.5119220018386841},{"id":"https://openalex.org/C2780586759","wikidata":"https://www.wikidata.org/wiki/Q16889688","display_name":"Congelation","level":2,"score":0.5037299990653992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4992403984069824},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47864997386932373},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47322192788124084},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.46039408445358276},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4189627170562744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34665447473526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19593042135238647},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.18065115809440613},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007053","descriptor_name":"Ice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011898","descriptor_name":"Ranidae","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D011898","descriptor_name":"Ranidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1992.263.1.r185","doi":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1992.263.1.r185","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:1636785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1636785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1818118904","display_name":"ORGAN CRYOPRESERVATION AND FREEZE-TOLERANT VERTEBRATES","funder_award_id":"R01GM043796","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983055342","https://openalex.org/W2319689578","https://openalex.org/W2096094651","https://openalex.org/W2049506545","https://openalex.org/W2061463856","https://openalex.org/W2196600433","https://openalex.org/W2168781193","https://openalex.org/W2053114850","https://openalex.org/W2064902399","https://openalex.org/W2204140692"],"abstract_inverted_index":{"The":[0,152],"technique":[1],"of":[2,17,27,93,123,131,160,167,175,180],"directional":[3,38],"solidification":[4],"coupled":[5],"with":[6,52,128],"low-temperature":[7],"scanning":[8],"electron":[9],"microscopy":[10],"was":[11,126],"applied":[12],"to":[13,40],"analyze":[14],"the":[15,21,37,91,129,145,155,161,172,176],"freezing":[16,67,162,187],"liver":[18,28,76,143],"slices":[19,29,77],"from":[20,30],"freeze-tolerant":[22,169],"frog":[23],"Rana":[24],"sylvatica.":[25],"Micrographs":[26],"5":[31],"degrees":[32,42,71,84,118,147],"C-acclimated":[33],"frogs":[34,62],"frozen":[35,79],"on":[36],"stage":[39],"-7":[41,83,117],"C":[43,72,85,148],"showed":[44],"continuous":[45],"ice":[46,95],"formed":[47],"along":[48],"an":[49,165],"expanded":[50],"vasculature":[51],"hepatocytes":[53,115],"that":[54,108],"were":[55,63,86,100],"shrunken":[56,89],"and":[57,90,171,186],"virtually":[58],"dehydrated.":[59],"However,":[60],"when":[61,98],"given":[64],"a":[65,140,168,181],"survivable":[66],"exposure":[68,149],"at":[69,82,116],"-4":[70,146],"for":[73],"24":[74],"h,":[75],"subsequently":[78],"in":[80,113,142,150,164],"vitro":[81],"much":[87],"less":[88],"presence":[92],"intracellular":[94],"crystals":[96],"(formed":[97],"samples":[99],"plunged":[101],"into":[102],"liquid":[103],"N2":[104],"before":[105],"microscopy)":[106],"demonstrated":[107],"ample":[109],"free":[110],"water":[111],"remained":[112],"these":[114,190],"C.":[119],"This":[120],"reduced":[121],"level":[122],"cell":[124,184],"dehydration":[125],"correlated":[127],"buildup":[130],"280":[132],"+/-":[133],"61":[134],"mumol/g":[135],"wet":[136],"wt":[137],"glucose":[138],"as":[139],"cryoprotectant":[141],"during":[144],"vivo.":[151],"study":[153],"provides":[154],"first":[156,173],"direct":[157],"cytological":[158],"analysis":[159],"process":[163],"organ":[166],"vertebrate":[170],"confirmation":[174],"relationship":[177],"between":[178],"maintenance":[179],"critical":[182],"minimum":[183],"volume":[185],"survival":[188],"by":[189],"animals.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
