{"id":"https://openalex.org/W2294897979","doi":null,"title":"Traditional bone matrix proteins in obesity, insulin resistance and diabetes: state of the art and perspectives.","display_name":"Traditional bone matrix proteins in obesity, insulin resistance and diabetes: state of the art and perspectives.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2294897979","mag":"2294897979"},"language":"en","primary_location":{"id":"mag:2294897979","doi":null,"is_oa":false,"landing_page_url":"http://www.hvm.bioflux.com.ro/docs/2015.215-220.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Human & Veterinary Medicine/Human & Veterinary Medicine - International Journal of the Bioflux Society","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049002141","display_name":"Monica Goia-Socol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Goia-Socol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069459610","display_name":"Carmen Emanuela Georgescu","orcid":"https://orcid.org/0000-0002-6633-4885","observed_orcids":["https://orcid.org/0000-0002-6633-4885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Emanuela Georgescu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6633-4885","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"215","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.39329999685287476,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.39329999685287476,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.33059999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9779999852180481},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/bone-matrix-proteins","display_name":"bone matrix proteins","score":0.9330000281333923},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.875},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/undercarboxylated-osteocalcin","display_name":"undercarboxylated osteocalcin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6299999952316284},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.5920000076293945},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7570000290870667},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9079999923706055},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8372483849525452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8036265969276428},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6754637956619263},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.605714738368988},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.59381103515625},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5579993724822998},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5540793538093567},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5514833927154541},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5399752259254456},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.43244606256484985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39036259055137634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34428584575653076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3208807706832886},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.1268056333065033},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.12143167853355408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0736241340637207},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2294897979","doi":null,"is_oa":false,"landing_page_url":"http://www.hvm.bioflux.com.ro/docs/2015.215-220.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Human & Veterinary Medicine/Human & Veterinary Medicine - International Journal of the Bioflux Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1911849097","https://openalex.org/W1970917808","https://openalex.org/W1971209429","https://openalex.org/W1972517405","https://openalex.org/W1978737811","https://openalex.org/W1980740451","https://openalex.org/W1988580567","https://openalex.org/W1993436216","https://openalex.org/W2001018521","https://openalex.org/W2013966444","https://openalex.org/W2025461698","https://openalex.org/W2025628030","https://openalex.org/W2026741932","https://openalex.org/W2028107793","https://openalex.org/W2034264001","https://openalex.org/W2036381935","https://openalex.org/W2043567984","https://openalex.org/W2043588395","https://openalex.org/W2043793746","https://openalex.org/W2047761422","https://openalex.org/W2048096271","https://openalex.org/W2049293597","https://openalex.org/W2052671136","https://openalex.org/W2060252384","https://openalex.org/W2060514084","https://openalex.org/W2060814786","https://openalex.org/W2070167771","https://openalex.org/W2073025399","https://openalex.org/W2087696761","https://openalex.org/W2094803729","https://openalex.org/W2100376056","https://openalex.org/W2102389494","https://openalex.org/W2111198585","https://openalex.org/W2119905591","https://openalex.org/W2121204955","https://openalex.org/W2122928145","https://openalex.org/W2129786688","https://openalex.org/W2139651989","https://openalex.org/W2146227998","https://openalex.org/W2159566085","https://openalex.org/W2202639318","https://openalex.org/W2289074647","https://openalex.org/W2338952753"],"related_works":["https://openalex.org/W4313654729","https://openalex.org/W2186070463","https://openalex.org/W1988580567","https://openalex.org/W2368962329","https://openalex.org/W7046040464","https://openalex.org/W3029331156","https://openalex.org/W2093392242","https://openalex.org/W4401610677","https://openalex.org/W2800479776","https://openalex.org/W2054663827"],"abstract_inverted_index":{"but":[0,249],"has":[1],"also":[2,252,420],"been":[3],"associated":[4,192],"with":[5,167,193,217,422],"glucose":[6,70,257],"metabolism":[7,149],"and":[8,30,32,41,89,102,108,112,131,169,219,229,241,256,276,289,301,307,311,329,336,344,361,398,424,444,452,461,468],"some":[9],"hormonal":[10],"actions":[11],"(Zhong":[12],"et":[13,17,21,73,134,152,197],"al":[14,18,22,74,135,153,198],"2015,":[15],"Zanatta":[16],"2014,":[19],"Abdallah":[20],"2015).":[23,154,199],"OCN":[24,82,95,117,130,164,189,212,282,293,317,328],"is":[25,264,332,356,368],"produced":[26],"by":[27,334,346,358],"osteoblasts,":[28],"osteocytes":[29],"odontoblasts,":[31],"can":[33,425],"undergo":[34],"\u03b3-carboxylation.":[35],"The":[36,62,259,373],"\u03b3-carboxylated":[37],"forms":[38,55],"bind":[39],"hydroxyapatite":[40],"are":[42,56,96,114,232,251,295,313],"found":[43],"in":[44,58,106,116,119,147,158,215,235,254,272,305,315,342,364,371,400,408,411,434],"the":[45,50,53,59,80,128,140,161,175,185,205,236,267,326,392,412],"bone":[46,237,244,316],"extracellular":[47,413],"matrix,":[48],"while":[49],"majority":[51],"of":[52,69,94,163,187,204,210,243,261,269,375,384,394,415,431,463],"undercarboxylated":[54,129,327],"released":[57],"circulatory":[60],"system.":[61],"latter":[63],"act":[64,426],"as":[65,122,174,320,427],"a":[66,123,201,321,339,405,438],"positive":[67,439],"regulator":[68],"homeostasis":[71],"(Zanatta":[72,133],"2014).":[75,136],"Multiple":[76,155],"studies":[77,156,223],"suggest":[78],"that":[79],"circulating":[81,165,188],"exhibits":[83,283],"biological":[84,284],"effects":[85,285],"on":[86,286],"pancreatic":[87,287],"\u03b2-cells":[88,288],"adipose":[90,109,290,308,365,416],"tissue.":[91,110,291,309,366,417],"Undercarboxylated":[92,292],"isoforms":[93,294],"hormonally":[97,296],"active,":[98,297],"stimulating":[99,298],"insulin":[100,104,113,132,274,299,303,312,350,432,466],"secretion":[101,118,300,318],"increasing":[103,302],"sensitivity":[105,304],"muscles":[107,306],"Leptin":[111,310],"involved":[115,253,314],"bone,":[120],"acting":[121,319],"feed":[124,322],"forward":[125,323],"loop":[126,324],"between":[127,325,441],"In":[137,181],"this":[138,262,403],"mechanism,":[139],"endocrine":[141],"skeleton":[142],"plays":[143],"an":[144,428],"important":[145],"role":[146,341,407],"energy":[148,255],"regulation":[150,454],"(Abdallah":[151],"conducted":[157],"humans":[159],"analyzed":[160],"associations":[162],"levels":[166,209,443],"T2DM":[168,218,345],"related":[170,469],"metabolic":[171,220,470],"phenotypes":[172],"such":[173],"polycystic":[176],"ovary":[177],"syndrome":[178],"(Pepene":[179],"2013).":[180],"Chinese":[182],"post-menopausal":[183],"women,":[184],"level":[186,374],"was":[190,419],"inversely":[191],"visceral":[194],"fat":[195],"(Luo":[196],"Following":[200],"systematic":[202],"review":[203,263],"published":[206],"literature,":[207],"decreased":[208],"serum":[211],"were":[213],"identified":[214],"patients":[216],"syndrome.":[221],"Cross-sectional":[222],"Abstract.":[224],"Osteocalcin":[225],"(OCN),":[226],"osteonectin":[227],"(ON)":[228],"osteopontin":[230],"(OPN)":[231],"proteins":[233,271],"included":[234],"matrix.":[238],"Bone":[239],"development":[240],"maintenance":[242],"functions":[245],"represent":[246,456],"main":[247],"tasks,":[248],"they":[250],"metabolism.":[258],"aim":[260],"to":[265,349,387],"summarize":[266],"roles":[268],"these":[270],"obesity,":[273,465],"resistance":[275,351,433,467],"type":[277],"2":[278],"diabetes":[279],"(T2DM).":[280],"Circulating":[281],"insulin.":[330],"OPN":[331,453],"secreted":[333],"adipocytes":[335],"may":[337],"play":[338],"pivotal":[340],"obesity":[343,348],"linking":[347],"development.":[352],"This":[353],"pathological":[354],"process":[355],"started":[357],"inflammation":[359],"initiation":[360],"macrophages":[362],"accumulation":[363],"ON":[367,418,442,451],"mainly":[369],"expressed":[370],"adipocytes.":[372],"expression":[376],"varies":[377],"during":[378,382],"adipogenesis":[379],"stages":[380],"(high":[381],"promotion":[383],"cell":[385,396],"differentiation":[386,397],"adipogenic":[388],"lineage,":[389],"low":[390],"at":[391],"beginning":[393],"adipocyte":[395],"high":[399],"mature":[401],"adipocytes);":[402],"suggests":[404],"potential":[406],"lipid":[409],"storage":[410],"matrix":[414],"correlated":[421],"dyslipidemia,":[423],"independent":[429],"determinant":[430],"late":[435],"pregnancy,":[436],"suggesting":[437],"correlation":[440],"inflammation.":[445],"Potential":[446],"novel":[447],"therapies":[448],"targeting":[449],"OCN,":[450],"could":[455],"promising":[457],"approaches":[458],"for":[459],"prevention":[460],"treatment":[462],"T2DM,":[464],"outcomes.":[471]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
