{"id":"https://openalex.org/W2294718267","doi":null,"title":"Role of the Slingshot-Cofilin and RanBP9 pathways in Alzheimer's Disease Pathogenesis","display_name":"Role of the Slingshot-Cofilin and RanBP9 pathways in Alzheimer's Disease Pathogenesis","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2294718267","mag":"2294718267"},"language":"en","primary_location":{"id":"pmh:oai:scholarcommons.usf.edu:etd-7243","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/6047","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7243&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7243&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011658431","display_name":"Jung A. Woo","orcid":"https://orcid.org/0000-0002-9194-1361","observed_orcids":["https://orcid.org/0000-0002-9194-1361"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jung A. Woo","raw_affiliation_strings":["University of South Florida"],"raw_orcid":"https://orcid.org/0000-0002-9194-1361","affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011658431"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.762213945388794},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4696109890937805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4088750183582306},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36937659978866577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26650452613830566},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22553536295890808}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarcommons.usf.edu:etd-7243","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/6047","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7243&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.usf.edu:etd-7243","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/etd/6047","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"mag:2294718267","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=7243&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarcommons.usf.edu:etd-7243","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/6047","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7243&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294718267.pdf","grobid_xml":"https://content.openalex.org/works/W2294718267.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W1428351561","https://openalex.org/W1492557229","https://openalex.org/W1550326833","https://openalex.org/W1568076991","https://openalex.org/W1568303755","https://openalex.org/W1585245628","https://openalex.org/W1591312627","https://openalex.org/W1608064905","https://openalex.org/W1622692223","https://openalex.org/W1623920471","https://openalex.org/W1745634660","https://openalex.org/W1965552543","https://openalex.org/W1967321689","https://openalex.org/W1968674432","https://openalex.org/W1968915824","https://openalex.org/W1968937229","https://openalex.org/W1969099023","https://openalex.org/W1974888639","https://openalex.org/W1975598541","https://openalex.org/W1977956545","https://openalex.org/W1984924722","https://openalex.org/W1985086842","https://openalex.org/W1985203436","https://openalex.org/W1987651098","https://openalex.org/W1988453500","https://openalex.org/W1992888364","https://openalex.org/W1993465897","https://openalex.org/W1994823881","https://openalex.org/W1998123755","https://openalex.org/W1999845366","https://openalex.org/W2000075190","https://openalex.org/W2000508605","https://openalex.org/W2001704669","https://openalex.org/W2003736664","https://openalex.org/W2004324219","https://openalex.org/W2007604900","https://openalex.org/W2009262775","https://openalex.org/W2020819434","https://openalex.org/W2020824841","https://openalex.org/W2023200476","https://openalex.org/W2024718473","https://openalex.org/W2025561374","https://openalex.org/W2026299157","https://openalex.org/W2028312858","https://openalex.org/W2029231027","https://openalex.org/W2030602441","https://openalex.org/W2032536251","https://openalex.org/W2032879521","https://openalex.org/W2035302673","https://openalex.org/W2037386201","https://openalex.org/W2040732053","https://openalex.org/W2042075182","https://openalex.org/W2044247371","https://openalex.org/W2044824015","https://openalex.org/W2044899507","https://openalex.org/W2044904524","https://openalex.org/W2048718653","https://openalex.org/W2048956603","https://openalex.org/W2049166174","https://openalex.org/W2050068554","https://openalex.org/W2050644696","https://openalex.org/W2051613123","https://openalex.org/W2053665966","https://openalex.org/W2053858663","https://openalex.org/W2055453151","https://openalex.org/W2055589857","https://openalex.org/W2057717465","https://openalex.org/W2061268870","https://openalex.org/W2061342941","https://openalex.org/W2061538653","https://openalex.org/W2062106937","https://openalex.org/W2062990728","https://openalex.org/W2068011527","https://openalex.org/W2068259590","https://openalex.org/W2073593094","https://openalex.org/W2076968916","https://openalex.org/W2077426275","https://openalex.org/W2078012311","https://openalex.org/W2078242348","https://openalex.org/W2081768153","https://openalex.org/W2082024168","https://openalex.org/W2082506839","https://openalex.org/W2082970812","https://openalex.org/W2084280842","https://openalex.org/W2084972185","https://openalex.org/W2085151093","https://openalex.org/W2093910429","https://openalex.org/W2094205678","https://openalex.org/W2094765619","https://openalex.org/W2100622486","https://openalex.org/W2107538476","https://openalex.org/W2107611011","https://openalex.org/W2108386295","https://openalex.org/W2109137926","https://openalex.org/W2109495146","https://openalex.org/W2110118397","https://openalex.org/W2110888808","https://openalex.org/W2111757377","https://openalex.org/W2116784956","https://openalex.org/W2117547988","https://openalex.org/W2118076063","https://openalex.org/W2120762331","https://openalex.org/W2121448546","https://openalex.org/W2125985978","https://openalex.org/W2128401893","https://openalex.org/W2129636426","https://openalex.org/W2130788782","https://openalex.org/W2132485762","https://openalex.org/W2133103790","https://openalex.org/W2134897953","https://openalex.org/W2135309154","https://openalex.org/W2135577930","https://openalex.org/W2136673626","https://openalex.org/W2138291830","https://openalex.org/W2140323904","https://openalex.org/W2142943752","https://openalex.org/W2143868008","https://openalex.org/W2146417626","https://openalex.org/W2150110395","https://openalex.org/W2150724305","https://openalex.org/W2150999725","https://openalex.org/W2151843908","https://openalex.org/W2152002380","https://openalex.org/W2154755614","https://openalex.org/W2158806622","https://openalex.org/W2161428211","https://openalex.org/W2161685550","https://openalex.org/W2161873934","https://openalex.org/W2162614357","https://openalex.org/W2164136371","https://openalex.org/W2164510688","https://openalex.org/W2164656879","https://openalex.org/W2165906760","https://openalex.org/W2168025729","https://openalex.org/W2171344422","https://openalex.org/W2171526610","https://openalex.org/W2303325200","https://openalex.org/W2313161798"],"related_works":["https://openalex.org/W1979730343","https://openalex.org/W2100331253","https://openalex.org/W1967678083","https://openalex.org/W2975806923","https://openalex.org/W4315927903","https://openalex.org/W3110518257","https://openalex.org/W2095661340","https://openalex.org/W2272690659","https://openalex.org/W2044703656","https://openalex.org/W2896484158"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"is":[3,24,76],"a":[4],"neurodegenerative":[5],"disorder":[6],"characterized":[7],"by":[8,213],"two":[9],"major":[10],"pathological":[11],"hallmarks,":[12],"amyloid":[13],"plaques":[14],"and":[15,31,42,70,83,116,135,148,161,178,204,232,241,262,270,279,291,309,348,370,385,423],"neurofibrillary":[16],"tangles.":[17],"The":[18],"accumulation":[19],"of":[20,44,80,107,113,118,128,140,215,251,313,326,334,342,350,418],"amyloid-\u03b2":[21],"protein":[22,230,254,379],"(A\u03b2)":[23],"an":[25,62,77],"early":[26],"event":[27],"associated":[28],"with":[29,103],"synaptic":[30,66,158,229,239,287,351,378,382,424],"mitochondrial":[32,68,156,175,271,422],"damage":[33],"in":[34,65,192,225,238,244,259,263,286,329,345,353,374,421,426],"AD.":[35,51],"Therefore,":[36],"molecular":[37],"pathways":[38],"underlying":[39],"the":[40,111,252],"neurotoxicity":[41,87,405],"generation":[43],"A\u03b2":[45,85,100,131,144,257,398,403],"represent":[46],"promising":[47],"therapeutic":[48],"targets":[49],"for":[50,339],"Recent":[52],"studies":[53],"have":[54],"shown":[55],"that":[56,166,196,209,222,249,302,320,371,392],"actin":[57],"severing":[58],"protein,":[59],"Cofilin":[60,75,92,119,133,171,176,226,268,314],"plays":[61],"important":[63],"role":[64],"remodeling,":[67],"dysfunction,":[69,157],"AD":[71,81,181,427],"pathogenesis.":[72,428],"However,":[73,273],"whether":[74,280],"essential":[78,416],"component":[79],"pathogenesis":[82],"how":[84,274],"induced":[86,132,404],"impinges":[88],"its":[89],"signals":[90],"to":[91,109,146,315],"are":[93],"unclear.\\nIn":[94],"my":[95,297],"dissertation":[96,298],"studies,":[97,299],"we":[98,164,194,300,318,358],"found":[99,165,248,301,360],"oligomers":[101],"bind":[102],"intermediate":[104],"activation":[105,117,139,211,269],"conformers":[106],"\u03b21-integrin":[108,115,129,141],"induce":[110],"loss":[112,127,231],"surface":[114],"via":[120,406],"Slingshot":[121],"homology-1":[122],"(SSH1)":[123],"activation.":[124],"Specifically,":[125],"conditional":[126],"prevented":[130,173],"activation,":[134,172],"allosteric":[136],"modulation":[137],"or":[138],"significantly":[142,185,365],"reduced":[143],"binding":[145],"neurons":[147,347],"mitigated":[149,170],"A\u03b242-induced":[150],"reactive":[151],"oxygen":[152],"species":[153],"(ROS)":[154],"generation,":[155],"proteins":[159,352],"depletion,":[160],"apoptosis.":[162],"Furthermore,":[163],"SSH1":[167,307],"reduction,":[168],"which":[169,207],"A\u03b2-induced":[174,284,340],"translocation":[177,312],"apoptosis,":[179],"while":[180,266],"brain":[182],"mitochondria":[183],"contained":[184],"increased":[186,366],"activated/oxidized":[187],"Cofilin.":[188],"In":[189,296,356],"mechanistic":[190],"support":[191],"vivo,":[193,357],"demonstrated":[195,319],"APP":[197,361],"transgenic":[198,264,362],"mice":[199,363],"brains":[200],"contain":[201],"decreased":[202],"SSH/Cofilin":[203],"SSH1/14-3-3":[205],"complexes":[206],"indicates":[208],"SSH-Cofilin":[210],"occurred":[212],"releasing":[214],"SSH":[216],"from":[217],"14-3-3.":[218],"We":[219],"also":[220,337,359,401],"showed":[221],"genetic":[223,372],"reduction":[224,373],"rescues":[227],"APP/A\u03b2-induced":[228,377],"gliosis,":[233,381],"as":[234,236],"well":[235],"impairments":[237,293],"plasticity":[240,383],"contextual":[242,386],"memory":[243,387],"vivo.\\nOur":[245],"lab":[246],"previously":[247],"overexpression":[250],"scaffolding":[253],"RanBP9":[255,276,282,304,322,335,368,375,394],"increases":[256],"production":[258,399],"cell":[260],"lines":[261],"mice,":[265],"promoting":[267],"dysfunction.":[272],"endogenous":[275,281,303,321,367,393],"activates":[277],"cofilin":[278],"accelerates":[283],"deficits":[285],"plasticity,":[288],"cofilin-dependent":[289],"pathology,":[290],"cognitive":[292],"were":[294],"unknown.":[295],"positively":[305,407],"regulates":[306],"levels":[308,369],"mediates":[310,323],"A\uf062-induced":[311,324],"mitochondria.":[316],"Moreover,":[317],"formation":[325],"Cofilin-actin":[327],"rods":[328],"primary":[330],"neurons.":[331,355],"Endogenous":[332],"level":[333],"was":[336],"required":[338],"collapse":[341],"growth":[343],"cones":[344],"immature":[346],"depletion":[349],"mature":[354],"exhibit":[364],"rescued":[376],"loss,":[380],"impairments,":[384],"deficits.":[388],"These":[389],"findings":[390,414],"indicated":[391],"not":[395],"only":[396],"promotes":[397],"but":[400],"meditate":[402],"regulating":[408],"SSH1.":[409],"Taken":[410],"together,":[411],"these":[412],"novel":[413],"implicate":[415],"involvement":[417],"\u03b21-integrin\u2013SSH1/RanBP9\u2013Cofilin":[419],"pathway":[420],"dysfunction":[425]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}