{"id":"https://openalex.org/W2294640652","doi":"https://doi.org/10.1523/jneurosci.2250-15.2016","title":"The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination","display_name":"The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination","publication_year":2016,"publication_date":"2016-03-09","ids":{"openalex":"https://openalex.org/W2294640652","doi":"https://doi.org/10.1523/jneurosci.2250-15.2016","mag":"2294640652","pmid":"https://pubmed.ncbi.nlm.nih.gov/26961956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4783501"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2250-15.2016","doi":"https://doi.org/10.1523/jneurosci.2250-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2250-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/10/3024.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/36/10/3024.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019400191","display_name":"Fucheng Luo","orcid":"https://orcid.org/0009-0007-3460-2375","observed_orcids":["https://orcid.org/0009-0007-3460-2375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fucheng Luo","raw_affiliation_strings":["Departments of Neurosciences and","1Departments of Neurosciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosciences and","institution_ids":[]},{"raw_affiliation_string":"1Departments of Neurosciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081388780","display_name":"Jessie Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessie Zhang","raw_affiliation_strings":["Departments of Neurosciences and","1Departments of Neurosciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosciences and","institution_ids":[]},{"raw_affiliation_string":"1Departments of Neurosciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033748411","display_name":"Kathryn Burke","orcid":"https://orcid.org/0009-0002-4920-6627","observed_orcids":["https://orcid.org/0009-0002-4920-6627"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Burke","raw_affiliation_strings":["Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037","4Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"4Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030332501","display_name":"Robert H. Miller","orcid":"https://orcid.org/0000-0001-9050-4154","observed_orcids":["https://orcid.org/0000-0001-9050-4154"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Miller","raw_affiliation_strings":["Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037 yxy33@case.edu rhm3@email.gwu.edu","4Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037 yxy33@case.edu rhm3@email.gwu.edu","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"4Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC 20037","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103534771","display_name":"Yan Yang","orcid":"https://orcid.org/0000-0002-8289-9851","observed_orcids":["https://orcid.org/0000-0002-8289-9851"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Yang","raw_affiliation_strings":["Neurology, Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, and yxy33@case.edu rhm3@email.gwu.edu","2Neurology,","3Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, and yxy33@case.edu rhm3@email.gwu.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"2Neurology,","institution_ids":[]},{"raw_affiliation_string":"3Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, and","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2273,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.73733518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"10","first_page":"3024","last_page":"3037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cdk5-p35","display_name":"Cdk5/p35","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oligodendrocyte-maturation","display_name":"oligodendrocyte maturation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.953000009059906},{"id":"https://openalex.org/keywords/oligodendrogenesis","display_name":"oligodendrogenesis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mouse-knockout-models","display_name":"mouse knockout models","score":0.38199999928474426},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.9476763010025024},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.7747771143913269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.757603645324707},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.6157819032669067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5907291769981384},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.485258549451828},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.45180124044418335},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.4351275861263275},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4165307879447937},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34258055686950684},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.23118510842323303},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.20249450206756592},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18375590443611145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11019206047058105},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.09841468930244446}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019081","descriptor_name":"O Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058635","descriptor_name":"Lipid-Linked Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058635","descriptor_name":"Lipid-Linked Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.2250-15.2016","doi":"https://doi.org/10.1523/jneurosci.2250-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2250-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/10/3024.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4783501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4783501","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:26961956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26961956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2250-15.2016","doi":"https://doi.org/10.1523/jneurosci.2250-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2250-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/10/3024.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1901062264","display_name":"development of oligodendrocytes in the spinal cord","funder_award_id":"R01NS030800","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G229917080","display_name":null,"funder_award_id":"NS3800","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7517105711","display_name":"Cdk5 regulates oligodendrocyte development, myelination and repair","funder_award_id":"R01NS077942","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294640652.pdf","grobid_xml":"https://content.openalex.org/works/W2294640652.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W310391750","https://openalex.org/W1490481380","https://openalex.org/W1914313496","https://openalex.org/W1964790765","https://openalex.org/W1968696851","https://openalex.org/W1969417329","https://openalex.org/W1970323747","https://openalex.org/W1979104943","https://openalex.org/W1979249872","https://openalex.org/W1979743829","https://openalex.org/W1980714951","https://openalex.org/W1984183927","https://openalex.org/W1997734809","https://openalex.org/W2001071023","https://openalex.org/W2011471381","https://openalex.org/W2011595739","https://openalex.org/W2015063977","https://openalex.org/W2016426012","https://openalex.org/W2018936216","https://openalex.org/W2023373446","https://openalex.org/W2024204517","https://openalex.org/W2028561442","https://openalex.org/W2031052253","https://openalex.org/W2033509883","https://openalex.org/W2038901745","https://openalex.org/W2043785832","https://openalex.org/W2044269722","https://openalex.org/W2045039385","https://openalex.org/W2047689431","https://openalex.org/W2048517810","https://openalex.org/W2052761964","https://openalex.org/W2052817786","https://openalex.org/W2056677926","https://openalex.org/W2059496781","https://openalex.org/W2064595948","https://openalex.org/W2068009600","https://openalex.org/W2069002586","https://openalex.org/W2072990016","https://openalex.org/W2077434215","https://openalex.org/W2077642972","https://openalex.org/W2078387449","https://openalex.org/W2081560586","https://openalex.org/W2085428659","https://openalex.org/W2089465156","https://openalex.org/W2091174313","https://openalex.org/W2092589801","https://openalex.org/W2093280889","https://openalex.org/W2102421748","https://openalex.org/W2104141496","https://openalex.org/W2114832016","https://openalex.org/W2116747568","https://openalex.org/W2117354631","https://openalex.org/W2117988483","https://openalex.org/W2119940607","https://openalex.org/W2128351119","https://openalex.org/W2128514286","https://openalex.org/W2132296918","https://openalex.org/W2137634153","https://openalex.org/W2140884992","https://openalex.org/W2142133262","https://openalex.org/W2143078634","https://openalex.org/W2146517909","https://openalex.org/W2152783554","https://openalex.org/W2153043611","https://openalex.org/W2156114958","https://openalex.org/W2160227323","https://openalex.org/W2301131921","https://openalex.org/W4252466484","https://openalex.org/W4298104955","https://openalex.org/W6677653402"],"related_works":["https://openalex.org/W2045039385","https://openalex.org/W2011471381","https://openalex.org/W1979104943","https://openalex.org/W2048517810","https://openalex.org/W2059665233","https://openalex.org/W1914313496","https://openalex.org/W6982194902","https://openalex.org/W2093280889","https://openalex.org/W2548142058","https://openalex.org/W7014853049"],"abstract_inverted_index":{"The":[0],"regulation":[1],"of":[2,21,47,55,60,69,77,93,104,116,140,156,181,186,192,227,235,241,250,256,264,274],"oligodendrocyte":[3,56,79,106,122,127,150,178,211,236,244,253,265,294],"development":[4,68,151,191,237,266],"and":[5,19,39,63,72,88,91,119,131,142,158,170,174,194,202,230,238,261,277,288],"myelin":[6],"formation":[7],"in":[8,97,121,177,304,306],"the":[9,17,25,67,75,89,98,102,154,225],"CNS":[10,22,99,200],"is":[11,196,208,217,219,309],"poorly":[12],"defined.":[13],"Multiple":[14],"signals":[15],"influence":[16],"rate":[18],"extent":[20,92],"myelination,":[23],"including":[24],"noncanonical":[26],"cyclin-dependent":[27,203],"kinase":[28,204],"5":[29,205],"(Cdk5)":[30,206],"whose":[31],"functions":[32],"are":[33],"regulated":[34],"by":[35,163,282],"its":[36],"activators":[37],"p35":[38,49,62,118,141,169,229,242,287],"p39.":[40],"Here":[41,221],"we":[42,222],"show":[43,223],"that":[44,224,286],"selective":[45],"loss":[46,59,115,155,249,273],"either":[48],"or":[50],"p39":[51,64,120,143,171,251,289],"perturbed":[52,96],"specific":[53,173],"aspects":[54],"development,":[57,179],"whereas":[58,248],"both":[61,117,257],"completely":[65,125,258],"inhibited":[66,126],"mature":[70],"oligodendrocytes":[71,193],"myelination.":[73,239,262],"In":[74,101],"absence":[76,103],"p35,":[78],"differentiation":[80,130],"was":[81,85,108,267],"delayed,":[82],"process":[83],"outgrowth":[84],"truncatedin":[86],"vitro,":[87],"patterning":[90],"myelination":[94,132,195,308],"were":[95],"ofp35\u2212/\u2212mice.":[100],"p39,":[105,231],"maturation":[107],"transiently":[109],"affected":[110],"bothin":[111,133],"vitroandin":[112],"vivo.":[113],"However,":[114],"lineage":[123],"cells":[124,271],"progenitor":[128,245],"cell":[129,246],"vitroand":[134],"after":[135],"transplantation":[136],"intoshivererslice":[137],"cultures.":[138],"Loss":[139,240,255],"had":[144],"a":[145],"more":[146,268],"profound":[147],"effect":[148],"on":[149],"than":[152,272],"simply":[153],"Cdk5":[157,164,187,215,275,283],"could":[159,278],"not":[160,279],"be":[161,184,280],"rescued":[162,281],"overexpression.":[165],"These":[166,296],"data":[167],"suggest":[168],"have":[172,290],"overlapping":[175],"roles":[176,292],"some":[180],"which":[182,307],"may":[183],"independent":[185],"activation.":[188],"SIGNIFICANCE":[189],"STATEMENTThe":[190],"essential":[197],"for":[198,210,301],"normal":[199],"function":[201],"activity":[207,216],"critical":[209],"maturation,":[212],"but":[213],"how":[214],"controlled":[218],"unclear.":[220],"coactivators":[226],"Cdk5,":[228],"regulate":[232],"distinct":[233],"stages":[234],"perturbs":[243],"differentiation,":[247],"delays":[252],"maturation.":[254],"inhibits":[259],"oligodendrogenesis":[260],"Disruption":[263],"pronounced":[269],"inp35\u2212/\u2212;p39shRNA":[270],"alone":[276],"overexpression,":[284],"suggesting":[285],"Cdk5-independent":[291],"during":[293],"development.":[295],"studies":[297],"provide":[298],"novel":[299],"targets":[300],"therapeutic":[302],"intervention":[303],"conditions":[305],"perturbed.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
