{"id":"https://openalex.org/W2294548904","doi":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","title":"Dose related coronary and systemic haemodynamic effects of intravenous bepridil in patients with coronary artery disease","display_name":"Dose related coronary and systemic haemodynamic effects of intravenous bepridil in patients with coronary artery disease","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W2294548904","doi":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","mag":"2294548904","pmid":"https://pubmed.ncbi.nlm.nih.gov/3494607"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.eurheartj.a062240","doi":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035807664","display_name":"Willem J. Remme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W. J. REMME","raw_affiliation_strings":["Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112194925","display_name":"Diederik C.A. Van Hoogenhuyze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.C.A. VAN HOOGENHUYZE","raw_affiliation_strings":["Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006404594","display_name":"X. H. Krauss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. H. KRAUSS","raw_affiliation_strings":["Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039611937","display_name":"Albert Hofman D","orcid":"https://orcid.org/0000-0002-9865-121X","observed_orcids":["https://orcid.org/0000-0002-9865-121X"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. HOFMAN","raw_affiliation_strings":["\u2020 Department of Epidemiology, Erasmus University Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Epidemiology, Erasmus University Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111670782","display_name":"Corstiaan J. Storm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. J. STORM","raw_affiliation_strings":["Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028088243","display_name":"H. A. C. M. Kruyssen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. A. C. M. KRUYSSEN","raw_affiliation_strings":["Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zuiderziekenhuis Rotterdam, The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035807664"],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":1.4669,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82794635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"2","first_page":"130","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bepridil","display_name":"bepridil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8529999852180481},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7009999752044678},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.859000027179718},{"id":"https://openalex.org/keywords/systemic-vasodilation","display_name":"systemic vasodilation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/left-ventricular-systolic-pressure","display_name":"left ventricular systolic pressure","score":0.8730000257492065},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7160000205039978},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.6190000176429749},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.6349999904632568},{"id":"https://openalex.org/keywords/negative-chronotropic-effect","display_name":"negative chronotropic effect","score":0.8309999704360962},{"id":"https://openalex.org/keywords/negative-inotropic-effect","display_name":"negative inotropic effect","score":0.9440000057220459},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9331725835800171},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6802952289581299},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6395995616912842},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.6383968591690063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6241539716720581},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.570896327495575},{"id":"https://openalex.org/C2778937662","wikidata":"https://www.wikidata.org/wiki/Q4890934","display_name":"Bepridil","level":4,"score":0.5694194436073303},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.5286600589752197},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5095634460449219},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5076144933700562},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4899574816226959},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.46473172307014465},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.45891129970550537},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.44005024433135986},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43600237369537354},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.4300830662250519},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42900604009628296},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.09309899806976318},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.058343321084976196}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015764","descriptor_name":"Bepridil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oxfordjournals.eurheartj.a062240","doi":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.eurheartj.a062240","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmid:3494607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3494607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:ehj:8/2/130","doi":null,"is_oa":false,"landing_page_url":"http://eurheartj.oxfordjournals.org/cgi/content/short/8/2/130","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030698513","https://openalex.org/W2043981470","https://openalex.org/W1992048248","https://openalex.org/W1999969593","https://openalex.org/W2405734711","https://openalex.org/W2046169868","https://openalex.org/W2103341154","https://openalex.org/W2017790834","https://openalex.org/W2008718943","https://openalex.org/W2120775563"],"abstract_inverted_index":{"The":[0],"acute":[1],"coronary":[2,16,40,87],"and":[3,26,39,47,69,81,85,93,104,116,136,154,159,182,188,252],"systemic":[4,38,137],"haemodynamic":[5,234],"effects":[6],"of":[7,65,77,89,242],"intravenous":[8,239],"bepridil":[9,186,258],"were":[10,53,209],"investigated":[11],"in":[12,43,59,73,86,128,173,196,211,219,229],"27":[13],"patients":[14],"with":[15,55,238,256],"artery":[17],"disease;":[18],"13":[19],"(group":[20,28,67,71,79,83,91,95,102,106],"1)":[21,68,80,92,103],"received":[22],"2":[23,130],"mg":[24,31],"kg-1":[25,32],"14":[27],"2)":[29,107],"4":[30],"over":[33],"5":[34,181],"min.":[35],"An":[36],"immediate":[37],"vasodilation":[41],"occurred":[42],"both":[44,141],"groups":[45],"during":[46,263],"immediately":[48,122],"after":[49,123,185],"the":[50,170],"infusion.":[51],"Changes":[52],"dose-related":[54],"a":[56,177,193,216,231],"maximal":[57],"decrease":[58,218],"left":[60],"ventricular":[61],"(LV)":[62],"systolic":[63],"pressure":[64,76,199],"11%":[66,78],"18%":[70],"2),":[72,84],"mean":[74],"aortic":[75],"19%":[82],"resistance":[88,138],"23%":[90],"41%":[94],"2).":[96],"Coronary":[97],"flow":[98],"increased":[99,134,157],"by":[100,176,192,248],"17%":[101],"47%":[105],"(all":[108],"changes":[109,208],"significantly":[110],"different":[111],"from":[112,215],"control":[113],"(C)":[114],"values":[115],"between":[117],"groups).":[118],"Cardiac":[119],"output,":[120],"measured":[121],"bepridil,":[124,240],"was":[125],"unaltered,":[126],"although":[127],"group":[129,149,212],"stroke":[131],"volume":[132],"index":[133],"(14%)":[135],"decreased":[139],"(16%),":[140],"P":[142,162,222],"less":[143,163,201,223],"than":[144,164,202,224],"0.05":[145,165,203,225],"vs":[146,166,204,226],"C.":[147],"In":[148],"2,":[150],"heart":[151],"rate":[152],"(HR)":[153],"contractility":[155],"initially":[156],"(8%":[158],"10%,":[160,189],"respectively,":[161],"C),":[167],"secondary":[168],"to":[169],"greater":[171],"fall":[172],"afterload,":[174],"followed":[175,247],"significant":[178],"reduction":[179],"at":[180],"10":[183],"min":[184],"(9%":[187],"respectively),":[190],"accompanied":[191],"36%":[194],"increase":[195],"LV":[197],"enddiastolic":[198],"(P":[200],"C).":[205,227],"No":[206],"such":[207],"observed":[210,237],"1,":[213],"apart":[214],"simultaneous":[217],"HR":[220],"(9%,":[221],"Thus,":[228],"humans,":[230],"dose-related,":[232],"biphasic":[233],"pattern":[235],"is":[236],"consisting":[241],"an":[243],"acute,":[244],"short-lasting":[245],"vasodilation,":[246],"late":[249],"negative":[250],"chronotropic":[251],"inotropic":[253],"effects,":[254],"which,":[255],"longterm":[257],"administration,":[259],"may":[260],"be":[261],"beneficial":[262],"myocardial":[264],"ischaemic.":[265]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}