{"id":"https://openalex.org/W2294547941","doi":"https://doi.org/10.1038/cddiscovery.2015.53","title":"A dual role for Caspase8 and NF-\u03baB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival","display_name":"A dual role for Caspase8 and NF-\u03baB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival","publication_year":2015,"publication_date":"2015-12-14","ids":{"openalex":"https://openalex.org/W2294547941","doi":"https://doi.org/10.1038/cddiscovery.2015.53","mag":"2294547941","pmid":"https://pubmed.ncbi.nlm.nih.gov/28179987","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5198842"},"language":"en","primary_location":{"id":"doi:10.1038/cddiscovery.2015.53","doi":"https://doi.org/10.1038/cddiscovery.2015.53","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddiscovery.2015.53","pdf_url":"https://www.nature.com/articles/cddiscovery201553.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddiscovery201553.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043029671","display_name":"Luis Alberto Parra Hern\u00e1ndez","orcid":"https://orcid.org/0000-0003-3908-3440","observed_orcids":["https://orcid.org/0000-0003-3908-3440"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Hernandez","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084510546","display_name":"Meyoung-kon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M K Kim","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009849305","display_name":"Anne M. Noonan","orcid":"https://orcid.org/0000-0001-8083-8492","observed_orcids":["https://orcid.org/0000-0001-8083-8492"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Noonan","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006688502","display_name":"Ethan Sagher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Sagher","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073326392","display_name":"Holger Kohlhammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Kohlhammer","raw_affiliation_strings":["Metabolism Branch, Center for Cancer Research, National Cancer Institute , Bethesda, MD 20892-1906, USA","Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Branch, Center for Cancer Research, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086207316","display_name":"George W. Wright","orcid":"https://orcid.org/0000-0003-0003-0843","observed_orcids":["https://orcid.org/0000-0003-0003-0843","https://orcid.org/0009-0002-3973-0791"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Wright","raw_affiliation_strings":["Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, MD 20892-1906, USA","Division of Cancer Treatment and Diagnosis, Biometric Research Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Division of Cancer Treatment and Diagnosis, Biometric Research Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025419264","display_name":"L. Tiffany Lyle","orcid":"https://orcid.org/0000-0003-1588-4876","observed_orcids":["https://orcid.org/0000-0003-1588-4876"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L T Lyle","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035391817","display_name":"Patricia Schriver Steeg","orcid":"https://orcid.org/0000-0002-2626-0594","observed_orcids":["https://orcid.org/0000-0002-2626-0594"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Steeg","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026882105","display_name":"Miriam R. Anver","orcid":"https://orcid.org/0000-0003-2665-8794","observed_orcids":["https://orcid.org/0000-0003-2665-8794"]},"institutions":[{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Anver","raw_affiliation_strings":["Pathology/Histotechnology Laboratory, LASP, Leidos Biomedical Research, Inc. , Frederick, MD 21702-1201, USA","Pathology/Histotechnology Laboratory, LASP, Leidos Biomedical Research, Inc., Frederick, 21702-1201, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology/Histotechnology Laboratory, LASP, Leidos Biomedical Research, Inc. , Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Pathology/Histotechnology Laboratory, LASP, Leidos Biomedical Research, Inc., Frederick, 21702-1201, MD, USA","institution_ids":["https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025082628","display_name":"David D.L. Bowtell","orcid":"https://orcid.org/0000-0001-9089-7525","observed_orcids":["https://orcid.org/0000-0001-9089-7525"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D D Bowtell","raw_affiliation_strings":["Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; The Department of Pathology, University of Melbourne, Parkville, Victoria, Australia","Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; The Department of Pathology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"on behalf of the Australian Ovarian Cancer Study Group","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"on behalf of the Australian Ovarian Cancer Study Group","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute, Bethesda, 20892-1906, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":null,"display_name":"C M Annunziata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C M Annunziata","raw_affiliation_strings":["Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Malignancies Branch, National Cancer Institute , Bethesda, MD 20892-1906, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.9529,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.70655982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"15053","last_page":"15053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.09629999846220016,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ciap","display_name":"cIAP","score":0.8489999771118164},{"id":"https://openalex.org/keywords/smac-mimetics","display_name":"IAP antagonists","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ikkbeta-inhibition","display_name":"IKK\u03b2 inhibition","score":0.8880000114440918},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.671999990940094},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7174412608146667},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.6572278141975403},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.6030598878860474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5811754465103149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5567705035209656},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5550011992454529},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5135707855224609},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49631720781326294},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47032415866851807},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45701009035110474},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4306970238685608},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41430699825286865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3288143575191498},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32606688141822815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29995197057724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20756477117538452},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08259418606758118}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/cddiscovery.2015.53","doi":"https://doi.org/10.1038/cddiscovery.2015.53","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddiscovery.2015.53","pdf_url":"https://www.nature.com/articles/cddiscovery201553.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},{"id":"pmid:28179987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28179987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5198842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5198842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discov","raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/258201","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/258201","pdf_url":"http://hdl.handle.net/11343/258201","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/cddiscovery.2015.53","doi":"https://doi.org/10.1038/cddiscovery.2015.53","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddiscovery.2015.53","pdf_url":"https://www.nature.com/articles/cddiscovery201553.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1521411027","display_name":null,"funder_award_id":"No. HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2462534994","display_name":null,"funder_award_id":"Contract No.,HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2474977437","display_name":null,"funder_award_id":"Contract No. HHSN261200800001E.","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4585269469","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294547941.pdf","grobid_xml":"https://content.openalex.org/works/W2294547941.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1480295646","https://openalex.org/W1970433780","https://openalex.org/W1979816280","https://openalex.org/W1979842763","https://openalex.org/W1980019367","https://openalex.org/W1984487910","https://openalex.org/W1986978728","https://openalex.org/W1990762111","https://openalex.org/W1992163987","https://openalex.org/W1992320631","https://openalex.org/W1993262772","https://openalex.org/W1996933769","https://openalex.org/W1999012914","https://openalex.org/W2000591680","https://openalex.org/W2005572311","https://openalex.org/W2008961838","https://openalex.org/W2013882958","https://openalex.org/W2016246269","https://openalex.org/W2030369269","https://openalex.org/W2034852369","https://openalex.org/W2035271331","https://openalex.org/W2039200873","https://openalex.org/W2042408180","https://openalex.org/W2043398720","https://openalex.org/W2046056065","https://openalex.org/W2046776183","https://openalex.org/W2077600211","https://openalex.org/W2078252006","https://openalex.org/W2079849392","https://openalex.org/W2080548340","https://openalex.org/W2094012816","https://openalex.org/W2095405582","https://openalex.org/W2097531829","https://openalex.org/W2110796758","https://openalex.org/W2118451050","https://openalex.org/W2119570092","https://openalex.org/W2130025456","https://openalex.org/W2131593373","https://openalex.org/W2134062610","https://openalex.org/W2141037581","https://openalex.org/W2142837807","https://openalex.org/W2142931749","https://openalex.org/W2143811153","https://openalex.org/W2169511366","https://openalex.org/W2170552969","https://openalex.org/W2216554257","https://openalex.org/W2727985987","https://openalex.org/W2759045790","https://openalex.org/W4293770031"],"related_works":["https://openalex.org/W2553385303","https://openalex.org/W2141341271","https://openalex.org/W2354498790","https://openalex.org/W2101457778","https://openalex.org/W3031401032","https://openalex.org/W3092287536","https://openalex.org/W4282915652","https://openalex.org/W2046096683","https://openalex.org/W2379685940","https://openalex.org/W2321788886"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"cancer":[2,50,81,121,156,166,181],"is":[3],"a":[4,57],"deadly":[5],"disease":[6],"characterized":[7,123],"by":[8,124,184,219],"primary":[9],"and":[10,28,37,128,149,195,206],"acquired":[11],"resistance":[12],"to":[13,41,177,217,228],"chemotherapy.":[14],"We":[15,39,140],"previously":[16],"associated":[17,98],"NF-":[18,46,76,161,189,202],"\u03ba":[19,47,77,162,190,203],"B":[20,78,163,191,204],"signaling":[21,174,205],"with":[22,66,75,90,99,210,233],"poor":[23],"survival":[24,65,102],"in":[25,45,79,103,119,164],"ovarian":[26,49,80,111,120,155,165,236],"cancer,":[27],"functionally":[29],"demonstrated":[30],"this":[31],"pathway":[32],"as":[33,56],"mediating":[34],"proliferation,":[35],"invasion":[36],"metastasis.":[38],"aimed":[40],"identify":[42],"cooperating":[43],"pathways":[44],"B-dependent":[48],"cells,":[51],"using":[52],"genome-wide":[53],"RNA":[54],"interference":[55],"loss-of-function":[58],"screen":[59,72],"for":[60,73,225,231],"key":[61],"regulators":[62],"of":[63,86,110,144,151,160,171,201,208],"cell":[64,138,157,198],"IKK":[67,91],"\u03b2":[68,92],"inhibition.":[69,93],"Functional":[70],"genomic":[71],"interactions":[74],"showed":[82],"that":[83,133],"cells":[84,167,182,215],"depleted":[85],"Caspase8":[87,96,114,134,145,186],"died":[88,183],"better":[89,129],"Overall,":[94],"low":[95,234],"was":[97,116],"shorter":[100],"overall":[101,130],"three":[104],"independent":[105],"gene":[106],"expression":[107,115,135],"data":[108],"sets":[109],"cancers.":[112],"Conversely,":[113],"markedly":[117],"highest":[118],"subtypes":[122],"strong":[125],"T-cell":[126],"infiltration":[127],"prognosis,":[131],"suggesting":[132],"increased":[136],"chemotherapy-induced":[137],"death.":[139,178,199],"investigated":[141],"the":[142,169],"effects":[143,170],"depletion":[146,187,207],"on":[147],"apoptosis":[148],"necroptosis":[150],"TNF":[152,172],"\u03b1":[153,173],"-stimulated":[154],"lines.":[158],"Inhibition":[159],"switched":[168],"from":[175],"proliferation":[176],"Although":[179],"Caspase8-high":[180],"apoptosis,":[185],"downregulated":[188],"signaling,":[192],"stabilized":[193],"RIPK1":[194],"promoted":[196],"necroptotic":[197],"Blockage":[200],"cIAP":[209],"SMAC-mimetic":[211],"further":[212],"rendered":[213],"these":[214],"susceptible":[216],"killing":[218],"necroptosis.":[220],"These":[221],"findings":[222],"have":[223],"implications":[224],"anticancer":[226],"strategies":[227],"improve":[229],"outcome":[230],"women":[232],"Caspase8-expressing":[235],"cancer.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}