{"id":"https://openalex.org/W2294313266","doi":null,"title":"Influ\u00eancia do topiramato na consolida\u00e7\u00e3o e extin\u00e7\u00e3o da mem\u00f3ria em modelo animal","display_name":"Influ\u00eancia do topiramato na consolida\u00e7\u00e3o e extin\u00e7\u00e3o da mem\u00f3ria em modelo animal","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2294313266","mag":"2294313266"},"language":"pt","primary_location":{"id":"pmh:oai:tede2.pucrs.br:tede/1511","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068621913","display_name":"Myriam Fortes Perrenoud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Myriam Fortes Perrenoud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068621913"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10918","display_name":"Memory Processes and Influences","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.984000027179718},{"id":"https://openalex.org/keywords/extinction-memory","display_name":"memory extinction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.8889999985694885},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/fear-memory","display_name":"fear memory","score":0.3700000047683716},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.621999979019165},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.33000001311302185},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6790000200271606},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5090000033378601},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3889999985694885},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6349999904632568},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3164138197898865}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:tede2.pucrs.br:tede/1511","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:1592570","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2294313266","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.pucrs.br/dspace/bitstream/10923/4502/1/000409596-Texto%2bCompleto-0.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tede2.pucrs.br:tede/1511","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","pdf_url":"http://tede2.pucrs.br/tede2/handle/tede/1511","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294313266.pdf","grobid_xml":"https://content.openalex.org/works/W2294313266.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W173488229","https://openalex.org/W1494590894","https://openalex.org/W1509419123","https://openalex.org/W1516399961","https://openalex.org/W1542009659","https://openalex.org/W1589966135","https://openalex.org/W1608535811","https://openalex.org/W1608611418","https://openalex.org/W1668354781","https://openalex.org/W1910362049","https://openalex.org/W1965373701","https://openalex.org/W1965591468","https://openalex.org/W1965924839","https://openalex.org/W1966709807","https://openalex.org/W1967370251","https://openalex.org/W1967434979","https://openalex.org/W1975940030","https://openalex.org/W1978489779","https://openalex.org/W1979865603","https://openalex.org/W1980024704","https://openalex.org/W1983578528","https://openalex.org/W1983903556","https://openalex.org/W1984271017","https://openalex.org/W1985043270","https://openalex.org/W1986012256","https://openalex.org/W1989328178","https://openalex.org/W1989758467","https://openalex.org/W1991067890","https://openalex.org/W1991257553","https://openalex.org/W1994411649","https://openalex.org/W1996210392","https://openalex.org/W1996269662","https://openalex.org/W1996506320","https://openalex.org/W1998041825","https://openalex.org/W1999704907","https://openalex.org/W2001812713","https://openalex.org/W2002459043","https://openalex.org/W2003737567","https://openalex.org/W2003811885","https://openalex.org/W2007764163","https://openalex.org/W2007941705","https://openalex.org/W2008254240","https://openalex.org/W2009713996","https://openalex.org/W2018083571","https://openalex.org/W2018619396","https://openalex.org/W2021213423","https://openalex.org/W2022694793","https://openalex.org/W2023589715","https://openalex.org/W2026704544","https://openalex.org/W2029469204","https://openalex.org/W2029712849","https://openalex.org/W2035550082","https://openalex.org/W2039578096","https://openalex.org/W2040837347","https://openalex.org/W2041894539","https://openalex.org/W2042339761","https://openalex.org/W2042774531","https://openalex.org/W2043285983","https://openalex.org/W2044992592","https://openalex.org/W2047732845","https://openalex.org/W2049801562","https://openalex.org/W2050978010","https://openalex.org/W2055183512","https://openalex.org/W2055321263","https://openalex.org/W2060164946","https://openalex.org/W2060732248","https://openalex.org/W2061211105","https://openalex.org/W2062976739","https://openalex.org/W2063140187","https://openalex.org/W2063347068","https://openalex.org/W2064571005","https://openalex.org/W2067678435","https://openalex.org/W2068725378","https://openalex.org/W2069416181","https://openalex.org/W2071221437","https://openalex.org/W2071674869","https://openalex.org/W2077095958","https://openalex.org/W2077307551","https://openalex.org/W2078945917","https://openalex.org/W2079311923","https://openalex.org/W2083322751","https://openalex.org/W2083595840","https://openalex.org/W2085230334","https://openalex.org/W2087421035","https://openalex.org/W2088672673","https://openalex.org/W2093023279","https://openalex.org/W2093603007","https://openalex.org/W2098532348","https://openalex.org/W2100787849","https://openalex.org/W2104011131","https://openalex.org/W2107069925","https://openalex.org/W2108682124","https://openalex.org/W2109538913","https://openalex.org/W2110724392","https://openalex.org/W2111711407","https://openalex.org/W2129399226","https://openalex.org/W2130981472","https://openalex.org/W2135890562","https://openalex.org/W2136377010","https://openalex.org/W2138856572","https://openalex.org/W2142437226","https://openalex.org/W2146631925","https://openalex.org/W2147371223","https://openalex.org/W2150498136","https://openalex.org/W2157909788","https://openalex.org/W2159010352","https://openalex.org/W2161152137","https://openalex.org/W2167372951","https://openalex.org/W2168660234","https://openalex.org/W2170080849","https://openalex.org/W2172064651","https://openalex.org/W2313176671","https://openalex.org/W2417592731","https://openalex.org/W2969684434","https://openalex.org/W2994467311","https://openalex.org/W4295332804","https://openalex.org/W7101130784"],"related_works":["https://openalex.org/W7048111861","https://openalex.org/W102782035","https://openalex.org/W2001812713","https://openalex.org/W2809509632","https://openalex.org/W103065997","https://openalex.org/W1974028254","https://openalex.org/W2065143633","https://openalex.org/W2366921247","https://openalex.org/W7095675616","https://openalex.org/W2748225142"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"A":[1,55,176,258],"mem\u00f3ria":[2,25,96,131,159,315,357],"\u00e9":[3,26,112],"aquisi\u00e7\u00e3o,":[4],"consolida\u00e7\u00e3o":[5,65,155,182,264,335],"e":[6,32,38,44,52,57,134,140,144,156,172,265,290],"evoca\u00e7\u00e3o":[7,93],"de":[8,20,28,69,81,86,132,160,235,243,252,281,325,387],"informa\u00e7\u00f5es.":[9],"Envolve":[10],"sempre":[11],"um":[12,113,173,250,401,416],"componente":[13],"emocional,":[14],"que":[15,105,118,124,248,276,403,414],"se":[16,39,75,277,306],"acrescenta":[17],"\u00e0s":[18],"informa\u00e7\u00f5es":[19],"\u00edndole":[21,37],"cognitiva.":[22],"Quando":[23],"a":[24,61,102,128,149,181,212,263,279,288,334,354,367,375,391,420],"conseq\u00fc\u00eancia":[27],"uma":[29,99,301,381],"situa\u00e7\u00e3o":[30],"estressante":[31],"traum\u00e1tica,":[33,97],"envolve":[34],"emo\u00e7\u00f5es":[35],"dessa":[36],"estabelece":[40],"atrav\u00e9s":[41,68],"da":[42,64,66,95,130,135,158,198,239,283,314,336,356,361,393],"am\u00eddala":[43],"do":[45,79,151,178,260,310],"hipocampo,":[46],"sendo":[47],"mais":[48,341],"resistentes":[49],"\u00e0":[50,92,108],"extin\u00e7\u00e3o":[51,157,266,355,362],"ao":[53,77],"esquecimento.":[54],"ansiedade":[56],"o":[58,194,200,226,233,273,348],"estresse":[59,87,407],"influenciam":[60],"fase":[62],"inicial":[63],"mem\u00f3ria,":[67],"v\u00e1rias":[70],"vias":[71],"modulat\u00f3rias,":[72],"cujo":[73],"efeito":[74],"incorpora":[76],"restante":[78],"conte\u00fado":[80],"cada":[82],"mem\u00f3ria.":[83,337,394],"No":[84],"caso":[85,171],"particularmente":[88],"intenso,":[89],"h\u00e1":[90],"tend\u00eancia":[91],"reiterada":[94],"provocando":[98,138],"esquiva":[100,244],"persistente":[101],"qualquer":[103],"est\u00edmulo":[104],"seja":[106],"associado":[107],"mesma.":[109,376],"O":[110,228,328,338,350,377,396],"TOP":[111,152,179,201,261,311,329,351,378,397],"medicamento":[114,402],"eficaz":[115,342],"na":[116,154,312,422],"epilepsia,":[117],"tem":[119],"entre":[120],"seus":[121],"efeitos":[122],"colaterais,":[123],"s\u00e3o":[125],"concentra\u00e7\u00e3o":[126],"dependente,":[127],"diminui\u00e7\u00e3o":[129],"trabalho":[133],"flu\u00eancia":[136],"verbal,":[137],"confus\u00e3o":[139],"torpor.":[141],"Materiais,":[142],"m\u00e9todos":[143],"hip\u00f3teses":[145],"avaliadas:":[146],"Foi":[147,298],"avaliada":[148,184,268],"a\u00e7\u00e3o":[150,177,259,308],"(10mg/kg)":[153],"longa":[161],"dura\u00e7\u00e3o":[162],"em":[163,168,231,247,269,275],"84":[164],"ratos":[165],"Wistar,":[166],"divididos":[167],"6":[169],"grupos":[170],"grupo":[174],"controle.":[175],"sobre":[180,262],"foi":[183,202,267,340],"por":[185,204,255,318,363,371,380],"sua":[186],"administra\u00e7\u00e3o":[187],"imediatamente":[188],"ap\u00f3s,":[189],"ou":[190,208],"3":[191,345],"horas":[192,296],"ap\u00f3s":[193,225,347],"treino.":[195,227,349],"Na":[196],"avalia\u00e7\u00e3o":[197],"extin\u00e7\u00e3o,":[199,388],"administrado":[203,317,330,344,359,370,379],"14":[205,364],"dias":[206,210,224,320,373],"antes,":[207],"5":[209,319,372],"durante":[211,374],"extin\u00e7\u00e3o.":[213,326],"Em":[214],"todos":[215],"os":[216,218,221],"experimentos":[217],"animais":[219],"iniciaram":[220],"testes":[222,270],"15":[223],"treino":[229],"consistiu":[230],"medir":[232],"tempo":[234],"lat\u00eancia":[236,280],"para":[237,304],"descer":[238],"plataforma":[240,284],"no":[241,291],"paradigma":[242],"inibit\u00f3ria,":[245],"momento":[246],"receberam":[249],"choque":[251],"1":[253],"mA":[254],"2":[256],"segundos.":[257],"repetidos,":[271],"sem":[272,321,383],"choque,":[274],"mediu":[278],"descida":[282],"nos":[285],"tempos":[286],"T1":[287],"T5":[289],"teste":[292],"final":[293],"T6,":[294],"48":[295],"ap\u00f3s.":[297],"realizada":[299],"tamb\u00e9m":[300],"contra":[302],"prova":[303],"avaliar":[305],"havia":[307],"direta":[309],"perda":[313,392],"quando":[316,343,358,369],"passar":[322,384],"pelo":[323,385],"procedimento":[324,386],"Resultados:":[327],"p\u00f3s-treino":[331],"interferiu":[332],"com":[333,406],"resultado":[339],"h":[346],"n\u00e3o":[352,389],"induziu":[353],"antes":[360],"dias,":[365],"por\u00e9m":[366],"facilitou":[368],"semana,":[382],"provocou":[390],"Sugest\u00e3o:":[395],"talvez":[398],"possa":[399],"ser":[400],"auxilie":[404],"pacientes":[405],"p\u00f3s-traum\u00e1tico,":[408],"assim":[409],"como":[410],"aqueles":[411],"considerados":[412],"borderline,":[413],"apresentam":[415],"comportamento":[417],"autodestrutivo":[418],"relacionado":[419],"traumas":[421],"inf\u00e2ncia.":[423]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}