{"id":"https://openalex.org/W2294267237","doi":null,"title":"Chemical screening to uncover small molecules that modulate neural stem cell self-renewal and differentiation","display_name":"Chemical screening to uncover small molecules that modulate neural stem cell self-renewal and differentiation","publication_year":2015,"publication_date":"2015-05-28","ids":{"openalex":"https://openalex.org/W2294267237","mag":"2294267237"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1468463","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1468463/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004705695","display_name":"Bart Baranowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bart Baranowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004705695"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8489999771118164},{"id":"https://openalex.org/keywords/differentiation","display_name":"differentiation","score":0.48899999260902405},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nigericin","display_name":"nigericin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7222979068756104},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6283466219902039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6126885414123535},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5559689998626709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5255747437477112},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4991319179534912},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47567978501319885},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4466620683670044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39633122086524963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19625183939933777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12711462378501892},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1468463","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1468463/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2294267237","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1468463/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2109610561"],"related_works":["https://openalex.org/W2261178148","https://openalex.org/W2369681351","https://openalex.org/W4312094107","https://openalex.org/W212472206","https://openalex.org/W2379092892","https://openalex.org/W2379599042","https://openalex.org/W2883186437","https://openalex.org/W112290509","https://openalex.org/W2009340953","https://openalex.org/W2139044241"],"abstract_inverted_index":{"In":[0],"vitro":[1,51],"expanded":[2],"neural":[3,15,41,65],"stem":[4,33,42,66],"cells":[5,67,253],"provide":[6],"an":[7,92],"important":[8],"cellular":[9,127,235],"model":[10,128],"to":[11,39,68,119,155,210],"explore":[12],"mechanisms":[13],"of":[14,19,32,57,61,64,78,87,91,109,123,137,141,148,159,174,193,208],"development,":[16],"for":[17],"modelling":[18],"disease,":[20],"and":[21,73,152,164,222,237,245,254],"in":[22,29,50,189,204],"the":[23,58,62,85,113,191,205,233],"longer":[24],"term":[25],"may":[26],"have":[27],"applications":[28],"new":[30],"types":[31],"cell-based":[34],"therapies.":[35],"However,":[36,179],"our":[37],"ability":[38],"steer":[40],"(NS)":[43],"cell":[44,81,98,111,150,162],"lines":[45,82,99],"into":[46],"specific":[47,234],"desired":[48],"lineages":[49],"remains":[52],"limited.":[53],"PDGFR\u03b1":[54,88],"is":[55],"one":[56],"earliest":[59],"markers":[60],"transition":[63],"oligodendrocyte":[69],"progenitors.":[70],"I":[71,106,130,166,180,230],"established":[72],"characterised":[74],"a":[75,133,138,195],"novel":[76],"set":[77],"mouse":[79],"NS":[80,110,161,252,257],"that":[83,185,197],"report":[84],"activation":[86,192],"via":[89],"expression":[90],"H2B:GFP":[93,114],"\u2018knock-in\u2019.":[94],"Three":[95,212],"clonal":[96],"\u2018PG1\u2019":[97],"were":[100,186],"fully":[101],"characterised.":[102],"Under":[103],"self-renewing":[104],"conditions":[105],"found":[107,181],"<1%":[108],"express":[112],"reporter":[115],"but":[116],"this":[117,126],"increases":[118],"~15-20%":[120],"following":[121],"induction":[122],"differentiation.":[124,165],"Using":[125],"system":[129],"carried":[131],"out":[132],"high-content":[134],"chemical":[135],"screen":[136],"diverse":[139],"collection":[140],"463":[142],"pharmacologically":[143],"active":[144],"small":[145,171],"molecule":[146],"modulators":[147],"\u2018stem":[149],"pathways\u2019":[151],"kinase":[153],"inhibitors,":[154],"identify":[156],"those":[157],"capable":[158,173],"modulating":[160],"self-renewal":[163],"did":[167],"not":[168],"uncover":[169],"any":[170],"molecules":[172,244],"promoting":[175],"OPC":[176,228],"lineage":[177],"specification.":[178],"multiple":[182],"HDAC":[183,202],"inhibitors":[184],"highly":[187],"effective":[188],"blocking":[190],"PDGFR\u03b1,":[194],"finding":[196],"mirrors":[198],"published":[199],"studies":[200],"implicating":[201],"inhibition":[203],"later":[206],"differentiation":[207,248],"OPCs":[209],"oligodendrocytes.":[211],"further":[213],"compounds,":[214],"Nigericin":[215],"(an":[216],"ionophore),":[217],"Withaferin":[218],"(a":[219],"steroidal":[220],"lactone)":[221],"NFkB":[223],"inhibitor":[224],"also":[225],"completely":[226],"blocked":[227],"commitment.":[229],"focused":[231],"on":[232,250],"responses":[236],"downstream":[238],"molecular":[239],"events":[240],"triggered":[241],"by":[242],"these":[243],"tested":[246],"their":[247],"potential":[249],"human":[251],"malignant":[255],"glioblastoma-derived":[256],"cells.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}