{"id":"https://openalex.org/W2294201908","doi":null,"title":"THE THEORIES OF AGING: REACTIVE OXYGEN SPECIES AND WHAT ELSE?","display_name":"THE THEORIES OF AGING: REACTIVE OXYGEN SPECIES AND WHAT ELSE?","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W2294201908","mag":"2294201908","pmid":"https://pubmed.ncbi.nlm.nih.gov/26511196"},"language":"en","primary_location":{"id":"pmid:26511196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26511196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076011499","display_name":"Anna Avantaggiato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Avantaggiato","raw_affiliation_strings":["Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110613813","display_name":"Gianluigi Bertuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Bertuzzi","raw_affiliation_strings":["Master in Aesthetic Medicine, Department of Systems Medicine, University of Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Master in Aesthetic Medicine, Department of Systems Medicine, University of Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045121331","display_name":"Michele Pascali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Pascali","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V Candotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Candotto","raw_affiliation_strings":["Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030220758","display_name":"F Carinci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Carinci","raw_affiliation_strings":["Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7168,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.63918526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"3 Suppl 1","first_page":"156","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theories-of-aging","display_name":"theories of aging","score":0.9800000190734863},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antioxidant-intake","display_name":"antioxidant intake","score":0.7300000190734863},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain-dysfunction","display_name":"mitochondrial respiratory chain dysfunction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/membrane-damage","display_name":"membrane damage","score":0.4790000021457672},{"id":"https://openalex.org/keywords/hormesis","display_name":"hormesis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tor-signaling","display_name":"TOR signaling","score":0.5509999990463257},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.625},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6819999814033508},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.713831901550293},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7088310122489929},{"id":"https://openalex.org/C186256576","wikidata":"https://www.wikidata.org/wiki/Q1058294","display_name":"Hormesis","level":3,"score":0.6343721151351929},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.5611485838890076},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5446687340736389},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5347534418106079},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5224910378456116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4913457930088043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4672059416770935},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.45859211683273315},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.4533582925796509},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4520058035850525},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4051855504512787},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25668007135391235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2480667531490326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18032997846603394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11210009455680847},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.10005715489387512},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.095253586769104},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:26511196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26511196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unife.it:11392/2340696","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/2340696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2294201908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26511196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W47495918","https://openalex.org/W1497143641","https://openalex.org/W1563581895","https://openalex.org/W1656470045","https://openalex.org/W1963735805","https://openalex.org/W1972733192","https://openalex.org/W1973688807","https://openalex.org/W1975693372","https://openalex.org/W1984571004","https://openalex.org/W1989289507","https://openalex.org/W1993690286","https://openalex.org/W1997331485","https://openalex.org/W1997439652","https://openalex.org/W2001675597","https://openalex.org/W2004129180","https://openalex.org/W2004314923","https://openalex.org/W2008320064","https://openalex.org/W2009902514","https://openalex.org/W2030019992","https://openalex.org/W2044430178","https://openalex.org/W2050120083","https://openalex.org/W2050532980","https://openalex.org/W2056620406","https://openalex.org/W2059494962","https://openalex.org/W2083607270","https://openalex.org/W2096158640","https://openalex.org/W2096452837","https://openalex.org/W2114586610","https://openalex.org/W2123870698","https://openalex.org/W2124098526","https://openalex.org/W2126525177","https://openalex.org/W2131006126","https://openalex.org/W2137795454","https://openalex.org/W2150665743"],"related_works":["https://openalex.org/W1932882875","https://openalex.org/W39776827","https://openalex.org/W2019851617","https://openalex.org/W1982647833","https://openalex.org/W4393192542","https://openalex.org/W2479711467","https://openalex.org/W7100057574","https://openalex.org/W2135860443","https://openalex.org/W2403420317","https://openalex.org/W2043137911"],"abstract_inverted_index":{"This":[0],"manuscript":[1],"is":[2,139],"a":[3],"short":[4],"review":[5],"on":[6,13,126],"the":[7,14,17,20,28,32,48,55,60,81,110,115,119,123,144,146,150,152,157],"theories":[8,57,61],"of":[9,35,51,62,80,137,154],"aging,":[10],"focusing":[11],"mainly":[12],"balance":[15,158],"between":[16,118],"nutrient":[18],"and":[19,27,58,68,96,106,122,128,156],"oxygen":[21],"intake":[22,125],"necessary":[23],"for":[24,30],"energy":[25,36],"metabolism":[26],"processes":[29],"neutralizing":[31],"negative":[33],"consequences":[34],"production.":[37],"The":[38,72,135],"first":[39],"section":[40,74,112],"entitled":[41,75,113],"\u0093Why\u0094":[42],"provides":[43],"brief":[44,78],"historical":[45],"details":[46],"regarding":[47],"main":[49],"group":[50],"aging":[52,63,87,129],"theories,":[53],"firstly":[54],"evolutionary":[56],"secondly":[59],"related":[64],"to":[65,143],"humans,":[66],"cells":[67],"biomolecules":[69],"are":[70,133],"discussed.":[71,134],"second":[73],"\u0091Where\u0092":[76],"includes":[77],"summaries":[79],"many":[82],"cellular":[83],"levels":[84],"at":[85],"which":[86],"damage":[88],"can":[89],"occur:":[90],"replicative":[91],"senescence":[92],"with":[93],"its":[94],"genetic":[95],"epigenetic":[97],"implications,":[98],"cytoplasmic":[99],"accumulation,":[100],"mitochondrial":[101],"respiratory":[102],"chain":[103],"dysfunction,":[104],"peroxisome":[105],"membrane":[107],"activity.":[108],"In":[109],"third":[111],"\u0091How\u0092":[114],"linking":[116],"mechanisms":[117],"caloric":[120],"restriction":[121],"antioxidant":[124],"lifespan":[127],"in":[130,141],"experimental":[131],"models":[132],"role":[136],"ROS":[138],"evaluated":[140],"relation":[142],"mitochondria,":[145],"AMPK":[147],"activated":[148],"sirtuins,":[149],"hormesis,":[151],"target":[153],"rapamicin":[155],"autophagy/apoptosis.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}