{"id":"https://openalex.org/W2294059599","doi":"https://doi.org/10.1111/all.12878","title":"T follicular helper (Tfh) cells in normal immune responses and in allergic disorders","display_name":"T follicular helper (Tfh) cells in normal immune responses and in allergic disorders","publication_year":2016,"publication_date":"2016-03-12","ids":{"openalex":"https://openalex.org/W2294059599","doi":"https://doi.org/10.1111/all.12878","mag":"2294059599","pmid":"https://pubmed.ncbi.nlm.nih.gov/26970097"},"language":"en","primary_location":{"id":"doi:10.1111/all.12878","doi":"https://doi.org/10.1111/all.12878","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12878","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12878","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080048332","display_name":"Gilda Varricchi","orcid":"https://orcid.org/0000-0002-9285-4657","observed_orcids":["https://orcid.org/0000-0002-9285-4657"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Varricchi","raw_affiliation_strings":["Allergy and Clinical Immunology, Imperial College London, London, UK","Immunomodulation and Tolerance Group, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Clinical Immunology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Immunomodulation and Tolerance Group, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028949714","display_name":"James A. Harker","orcid":"https://orcid.org/0000-0002-0301-6898","observed_orcids":["https://orcid.org/0000-0002-0301-6898"]},"institutions":[{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Harker","raw_affiliation_strings":["Inflammation, Repair & Development Section Faculty of Medicine National Heart and Lung Institute Imperial College London London UK","MRC & Asthma UK Centre in Allergic Mechanisms of Asthma London UK","Inflammation, Repair & Development Section, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation, Repair & Development Section Faculty of Medicine National Heart and Lung Institute Imperial College London London UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC & Asthma UK Centre in Allergic Mechanisms of Asthma London UK","institution_ids":["https://openalex.org/I4210141571"]},{"raw_affiliation_string":"Inflammation, Repair & Development Section, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034826569","display_name":"Francesco Borriello","orcid":"https://orcid.org/0000-0001-9074-4828","observed_orcids":["https://orcid.org/0000-0001-9074-4828"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Borriello","raw_affiliation_strings":["Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089722463","display_name":"Gianni Marone","orcid":"https://orcid.org/0000-0002-9849-4701","observed_orcids":["https://orcid.org/0000-0002-9849-4701"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Marone","raw_affiliation_strings":["CNR Institute of Experimental Endocrinology and Oncology 'G. Salvatore', Naples, Italy","Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR Institute of Experimental Endocrinology and Oncology 'G. Salvatore', Naples, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043192106","display_name":"Stephen R. Durham","orcid":"https://orcid.org/0000-0001-5264-6207","observed_orcids":["https://orcid.org/0000-0001-5264-6207"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. R. Durham","raw_affiliation_strings":["Allergy and Clinical Immunology, Imperial College London, London, UK","Immunomodulation and Tolerance Group, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Clinical Immunology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Immunomodulation and Tolerance Group, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063862530","display_name":"Mohamed H. Shamji","orcid":"https://orcid.org/0000-0003-3425-3463","observed_orcids":["https://orcid.org/0000-0003-3425-3463"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. H. Shamji","raw_affiliation_strings":["Allergy and Clinical Immunology, Imperial College London, London, UK","Immunomodulation and Tolerance Group, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Clinical Immunology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Immunomodulation and Tolerance Group, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063862530"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":1.1889,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.75539568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"71","issue":"8","first_page":"1086","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.8930000066757202},{"id":"https://openalex.org/keywords/il-21-receptor","display_name":"IL-21 receptor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.8349999785423279},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8159999847412109},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.5789999961853027},{"id":"https://openalex.org/keywords/ige-response","display_name":"IgE response","score":0.8190000057220459},{"id":"https://openalex.org/keywords/allergy-pathogenesis","display_name":"allergy pathogenesis","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6691100001335144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6671122908592224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4683365821838379},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.46429333090782166},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.4483088254928589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09450474381446838}],"mesh":[{"descriptor_ui":"D000098546","descriptor_name":"Interleukin-21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055633","descriptor_name":"Immune System Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/all.12878","doi":"https://doi.org/10.1111/all.12878","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12878","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:26970097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26970097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/all.12878","doi":"https://doi.org/10.1111/all.12878","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.12878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12878","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7481271243","display_name":"Contextual manipulation of the IL-6 family of cytokines to alter and enhance CD4+ T cell immunity to respiratory viral infections.","funder_award_id":"101372","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322218","display_name":"Regione Campania","ror":"https://ror.org/02kg21794"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294059599.pdf","grobid_xml":"https://content.openalex.org/works/W2294059599.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1511903932","https://openalex.org/W1567420244","https://openalex.org/W1584972523","https://openalex.org/W1632856850","https://openalex.org/W1655378794","https://openalex.org/W1671849983","https://openalex.org/W1673999527","https://openalex.org/W1747435964","https://openalex.org/W1758397931","https://openalex.org/W1812517801","https://openalex.org/W1853217298","https://openalex.org/W1854615013","https://openalex.org/W1893843472","https://openalex.org/W1912949881","https://openalex.org/W1929236283","https://openalex.org/W1966657425","https://openalex.org/W1967267159","https://openalex.org/W1968038918","https://openalex.org/W1977237743","https://openalex.org/W1980609038","https://openalex.org/W1981732254","https://openalex.org/W1982386486","https://openalex.org/W1982595765","https://openalex.org/W1982898080","https://openalex.org/W1985173426","https://openalex.org/W1985577573","https://openalex.org/W1989647272","https://openalex.org/W1991271747","https://openalex.org/W1995635569","https://openalex.org/W1998123693","https://openalex.org/W1998299106","https://openalex.org/W1998403286","https://openalex.org/W2000167866","https://openalex.org/W2005142961","https://openalex.org/W2008931469","https://openalex.org/W2015200774","https://openalex.org/W2016844693","https://openalex.org/W2017219476","https://openalex.org/W2020303255","https://openalex.org/W2022039920","https://openalex.org/W2025535612","https://openalex.org/W2025705733","https://openalex.org/W2028001342","https://openalex.org/W2031095563","https://openalex.org/W2037020518","https://openalex.org/W2038386610","https://openalex.org/W2038976543","https://openalex.org/W2041302559","https://openalex.org/W2041888438","https://openalex.org/W2046989226","https://openalex.org/W2050509789","https://openalex.org/W2050753305","https://openalex.org/W2055923182","https://openalex.org/W2060637301","https://openalex.org/W2062043778","https://openalex.org/W2063906189","https://openalex.org/W2066489069","https://openalex.org/W2070486601","https://openalex.org/W2076599494","https://openalex.org/W2081613377","https://openalex.org/W2082871926","https://openalex.org/W2083283706","https://openalex.org/W2086970585","https://openalex.org/W2087061585","https://openalex.org/W2090070823","https://openalex.org/W2090916507","https://openalex.org/W2096475468","https://openalex.org/W2099295104","https://openalex.org/W2102364213","https://openalex.org/W2109963496","https://openalex.org/W2110043839","https://openalex.org/W2110455055","https://openalex.org/W2113687173","https://openalex.org/W2118403212","https://openalex.org/W2120203591","https://openalex.org/W2122939321","https://openalex.org/W2123082276","https://openalex.org/W2123093300","https://openalex.org/W2123910031","https://openalex.org/W2127654404","https://openalex.org/W2131002714","https://openalex.org/W2137688247","https://openalex.org/W2139237097","https://openalex.org/W2139565733","https://openalex.org/W2141083934","https://openalex.org/W2143168086","https://openalex.org/W2144690750","https://openalex.org/W2146168998","https://openalex.org/W2147450297","https://openalex.org/W2149285092","https://openalex.org/W2149652458","https://openalex.org/W2149668671","https://openalex.org/W2151962109","https://openalex.org/W2160872052","https://openalex.org/W2160927547","https://openalex.org/W2163229826","https://openalex.org/W2163828646","https://openalex.org/W2419191053","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W2146869675","https://openalex.org/W3028801264","https://openalex.org/W3030854996","https://openalex.org/W2395115239","https://openalex.org/W2352276652","https://openalex.org/W2099739487","https://openalex.org/W3093516898","https://openalex.org/W4200418268","https://openalex.org/W3032092419","https://openalex.org/W2593867471"],"abstract_inverted_index":{"Follicular":[0],"helper":[1],"T":[2,58],"cells":[3,25,32,39,59,91,117],"(Tfh":[4],")":[5],"are":[6,42],"located":[7],"within":[8],"germinal":[9],"centers":[10],"of":[11,63,70,77,86,111,119,126],"lymph":[12],"nodes.":[13],"Cognate":[14],"interaction":[15],"between":[16],"Tfh":[17,38,64,90,116],",":[18],"B":[19,24],"cells,":[20],"and":[21,28,40,46,51,88,92,96,108,114,118],"IL-21":[22,41,93],"drives":[23],"to":[26,35],"proliferate":[27],"differentiate":[29],"into":[30],"plasma":[31],"thereby":[33],"leading":[34],"antibody":[36],"production.":[37],"involved":[43],"in":[44,74,94,123],"infectious":[45],"autoimmune":[47],"diseases,":[48],"immunodeficiencies,":[49],"vaccination,":[50],"cancer.":[52],"Human":[53],"peripheral":[54],"blood":[55,89,115],"CXCR5(+)":[56],"CD4(+)":[57],"comprise":[60],"different":[61],"subsets":[62],"-like":[65],"cells.":[66],"Despite":[67],"the":[68,71,75,84,106,120,124],"importance":[69],"IgE":[72],"response":[73],"pathogenesis":[76],"allergic":[78,98,127],"disorders,":[79],"little":[80],"is":[81],"known":[82],"about":[83],"role":[85],"follicular":[87,113],"human":[95],"experimental":[97],"disease.":[99],"Here,":[100],"we":[101],"review":[102],"recent":[103],"advances":[104],"regarding":[105],"phenotypic":[107],"functional":[109],"characteristics":[110],"both":[112],"IL-21/IL-21R":[121],"system":[122],"context":[125],"disorders.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}